Zobrazeno 1 - 10 of 827 pro vyhledávání: '"Marsh JL"'
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Akademický článek
Clinical and cost effectiveness of mechanical support for severe ankle sprains: design of a randomised controlled trial in the emergency department [ISRCTN 37807450]
Autor: Hutton JL, Wilson S, Marsh JL, Clark M, Withers EJ, Nakash RA, Lamb SE, Szczepura A, Dale JR, Cooke MW
Publikováno v: BMC Musculoskeletal Disorders, Vol 6, Iss 1, p 1 (2005)
Abstract Background The optimal management for severe sprains (Grades II and III) of the lateral ligament complex of the ankle is unclear. The aims of this randomised controlled trial are to estimate (1) the clinical effectiveness of three methods of
Externí odkaz: https://doaj.org/article/a0e708c443544bcba27322f82654fe67
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Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington's disease (vol 27, pg 649, 2018)
Autor: Song, W, Zsindely, N, Farago, A, Marsh, JL, Bodai, L
Publikováno v: Song, W; Zsindely, N; Farago, A; Marsh, JL; & Bodai, L. (2018). Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington's disease (vol 27, pg 649, 2018). HUMAN MOLECULAR GENETICS, 27(4), 759-759. doi: 10.1093/hmg/ddy020. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/4hf7n7wx
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::7513d4b915c21d5c9708346f7bceedab
http://www.escholarship.org/uc/item/4hf7n7wx
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4
Combinatorial signaling by Twisted Gastrulation and Decapentaplegic
Autor: Marsh Jl, Mason Ed, Williams S, Grotendorst Gr
Publikováno v: Mason, ED; Williams, S; Grotendorst, GR; & Marsh, JL. (1997). Combinatorial signaling by twisted gastrulation and decapentaplegic. Mechanisms of Development, 64(1-2), 61-75. doi: 10.1016/S0925-4773(97)00049-X. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1d70k3b1
The Twisted Gastrulation (TSG) protein is one of five secreted proteins required to pattern the dorsal part of the early Drosophila embryo. Unlike the Decapentaplegic (DPP) protein that is required to pattern the entire dorsal half of the embryo, TSG
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40345116a05e1132038e1bbb6d21e6fa
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5
Morphometric analysis of Huntington's disease neurodegeneration in Drosophila
Autor: Song, W, Smith, MR, Syed, A, Lukacsovich, T, Barbaro, BA, Purcell, J, Bornemann, DJ, Burke, J, Marsh, JL
Publikováno v: Song, W; Smith, MR; Syed, A; Lukacsovich, T; Barbaro, BA; Purcell, J; et al.(2013). Morphometric analysis of Huntington's disease neurodegeneration in Drosophila. Methods in Molecular Biology, 1017, 41-57. doi: 10.1007/978-1-62703-438-8-3. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/46p4153p
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder. The HD gene encodes the huntingtin protein (HTT) that contains polyglutamine tracts of variable length. Expansions of the CAG repeat near the amino terminus to encode 40 o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::70838398ae43749e9858f449b043477f
http://www.escholarship.org/uc/item/46p4153p
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6
A novel target for Huntington's disease: ERK at the crossroads of signaling: The ERK signaling pathway is implicated in Huntington's disease and its upregulation ameliorates pathology
Autor: Bodai, L, Marsh, JL
Publikováno v: Bodai, L; & Marsh, JL. (2012). A novel target for Huntington's disease: ERK at the crossroads of signaling: The ERK signaling pathway is implicated in Huntington's disease and its upregulation ameliorates pathology. BioEssays, 34(2), 142-148. doi: 10.1002/bies.201100116. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3zv7g3zv
Activating the ERK pathway (extracellular signal-regulated kinase pathway) has proven beneficial in several models of Huntington's disease (HD), and drugs that are protective in HD models have recently been found to activate ERK. Thus, the ERK cascad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::6ed841f82e7cf06b8c37efd02d1d07d4
http://www.escholarship.org/uc/item/3zv7g3zv
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7
Pcaf modulates polyglutamine pathology in a Drosophila model of Huntington's disease
Autor: Bodai, L, Pallos, J, Thompson, LM, Marsh, JL
Publikováno v: Bodai, L; Pallos, J; Thompson, LM; & Marsh, JL. (2012). Pcaf modulates polyglutamine pathology in a Drosophila model of Huntington's disease. Neurodegenerative Diseases, 9(2), 104-106. doi: 10.1159/000330505. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1nn407bb
Huntingtin peptides with elongated polyglutamine domains, the root causes of Huntington's disease, hinder histone acetylation, which leads to transcriptional dysregulation. However, the range of acetyltransferases interacting with mutant Huntingtin h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::5a20caaaa31638c1ac0fcc60f96f8ead
http://www.escholarship.org/uc/item/1nn407bb
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8
Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington's disease
Autor: McConoughey, SJ, Basso, M, Niatsetskaya, ZV, Sleiman, SF, Smirnova, NA, Langley, BC, Mahishi, L, Cooper, AJL, Antonyak, MA, Cerione, RA, Li, B, Starkov, A, Chaturvedi, RK, Bea, MF, Coppola, G, Geschwind, DH, Ryu, H, Xia, L, Iismaa, SE, Pallos, J, Pasternack, R, Hils, M, Fan, J, Raymond, LA, Marsh, JL, Thompson, LM, Ratan, RR
Publikováno v: McConoughey, SJ; Basso, M; Niatsetskaya, ZV; Sleiman, SF; Smirnova, NA; Langley, BC; et al.(2010). Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington's disease. EMBO Molecular Medicine, 2(9), 349-370. doi: 10.1002/emmm.201000084. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9485z8k5
Caused by a polyglutamine expansion in the huntingtin protein, Huntington's disease leads to striatal degeneration via the transcriptional dysregulation of a number of genes, including those involved in mitochondrial biogenesis. Here we show that tra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::5b6d9166157d0cd9affe6fdc9676894a
http://www.escholarship.org/uc/item/9485z8k5
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9
Phosphorylation of Threonine 3: IMPLICATIONS FOR HUNTINGTIN AGGREGATION AND NEUROTOXICITY*
Autor: Aiken, CT, Steffan, JS, Guerrero, CM, Khashwji, H, Lukacsovich, T, Simmons, D, Purcell, JM, Menhaji, K, Zhu, YZ, Green, K, LaFerla, F, Huang, L, Thompson, LM, Marsh, JL
Publikováno v: Aiken, CT; Steffan, JS; Guerrero, CM; Khashwji, H; Lukacsovich, T; Simmons, D; et al.(2009). Phosphorylation of threonine 3: Implications for huntingtin aggregation and neurotoxicity. Journal of Biological Chemistry, 284(43), 29427-29436. doi: 10.1074/jbc.M109.013193. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/71k9t5m4
Huntingtin (Htt) is a widely expressed protein that causes tissue-specific degeneration when mutated to contain an expanded polyglutamine (poly(Q)) domain. Although Htt is large, 350 kDa, the appearance of amino-terminal fragments of Htt in extracts
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::50cea231d34ee0d0472afd737a3a750d
https://europepmc.org/articles/PMC2785575/
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CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice
Autor: Apostol, BL, Simmons, DA, Zuccato, C, Illes, K, Pallos, J, Casale, M, Conforti, P, Ramos, C, Roarke, M, Kathuria, S, Cattaneo, E, Marsh, JL, Thompson, LM
Publikováno v: Apostol, BL; Simmons, DA; Zuccato, C; Illes, K; Pallos, J; Casale, M; et al.(2008). CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice. Molecular and Cellular Neuroscience, 39(1), 8-20. doi: 10.1016/j.mcn.2008.04.007. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0721m9tm
Huntington's disease (HD) is a devastating neurodegenerative disorder caused by an expanded polyglutamine repeat within the protein Huntingtin (Htt). We previously reported that mutant Htt expression activates the ERK1/2 and JNK pathways [Apostol, B.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::13bc900a68d28eff4acb7d3ebc6aa9fb
http://www.escholarship.org/uc/item/0721m9tm
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