Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Marsden BD"'
Exploring the functional effect of a non-synonymous coding variant at the protein level requires multiple pieces of information to be interpreted appropriately. This is particularly important when embarking on the study of a potentially pathogenic va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857b2f8e0c1d7d9868cb2c614382b947
https://doi.org/10.1016/j.jmb.2022.167567
https://doi.org/10.1016/j.jmb.2022.167567
Autor:
Lumley, SF, Rodger, G, Constantinides, B, Sanderson, N, Chau, KK, Street, TL, O'Donnell, D, Howarth, A, Hatch, SB, Marsden, BD, Cox, S, James, T, Warren, F, Peck, LJ, Ritter, TG, de Toledo, Z, Warren, L, Axten, D, Cornall, RJ, Jones, EY, Stuart, DI, Screaton, G, Ebner, D, Hoosdally, S, Chand, M, Crook, DW, O'Donnell, A-M, Conlon, CP, Pouwels, KB, Walker, AS, Peto, TEA, Hopkins, S, Walker, TM, Stoesser, NE, Matthews, PC, Jeffery, K, Eyre, DW
Background Natural and vaccine-induced immunity will play a key role in controlling the SARS-CoV-2 pandemic. SARS-CoV-2 variants have the potential to evade natural and vaccine-induced immunity. Methods In a longitudinal cohort study of healthcare wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1064::581b542f6362100ce710054258d2627b
https://ora.ox.ac.uk/objects/uuid:fed8e73b-9020-41a4-93c2-2329a6b59f85
https://ora.ox.ac.uk/objects/uuid:fed8e73b-9020-41a4-93c2-2329a6b59f85
Autor:
Eyre, DW, Lumley, SF, O'Donnell, D, Campbell, M, Sims, E, Lawson, E, Warren, F, James, T, Cox, S, Howarth, A, Doherty, G, Hatch, SB, Kavanagh, J, Chau, KK, Fowler, PW, Swann, J, Volk, D, Yang-Turner, F, Stoesser, N, Matthews, PC, Dudareva, M, Davies, T, Shaw, RH, Peto, L, Downs, LO, Vogt, A, Amini, A, Young, BC, Drennan, PG, Mentzer, AJ, Skelly, DT, Karpe, F, Neville, MJ, Andersson, M, Brent, AJ, Jones, N, Martins Ferreira, L, Christott, T, Marsden, BD, Hoosdally, S, Cornall, R, Crook, DW, Stuart, DI, Screaton, G, Group, Oxford University Hospitals Staff Testing, Watson, AJ, Taylor, A, Chetwynd, A, Grassam-Rowe, A, Mighiu, AS, Peck, LJ, Ebner, D, Conlon, CP
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c76f76de4fc9e67f727b32ee73b4152
https://doi.org/10.7554/elife.60675
https://doi.org/10.7554/elife.60675
Autor:
Fedorov, O, Lingard, H, Wells, C, Monteiro, OP, Picaud, S, Keates, T, Yapp, C, Philpott, M, Martin, SJ, Felletar, I, Marsden, BD, Filippakopoulos, P, Müller, S, Knapp, S, Brennan, PE
Publikováno v:
Journal of Medicinal Chemistry
Bromodomains are gaining increasing interest as drug targets. Commercially sourced and de novo synthesized substituted [1,2,4]triazolo[4,3-a]phthalazines are potent inhibitors of both the BET bromodomains such as BRD4 as well as bromodomains outside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::743d9b400d3d2c4d25a3a009d369870a
https://doi.org/10.1021/jm401568s
https://doi.org/10.1021/jm401568s
Autor:
Nentwich, HA, Mustafa, Z, Rugg, MS, Marsden, BD, Cordell, MR, Mahoney, DJ, Jenkins, SC, Dowling, B, Fries, E, Milner, CM, Loughlin, J, Day, AJ
Tumor necrosis factor-stimulated gene-6 (TSG-6) encodes a 35-kDa protein, which is comprised of contiguous Link and CUB modules. TSG-6 protein has been detected in the articular joints of osteoarthritis (OA) patients, with little or no constitutive e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ad36c24cae7e84b6e5b97d08b63c90e8
https://ora.ox.ac.uk/objects/uuid:230fe7b6-31b6-479f-9bd9-b5f6062df8e8
https://ora.ox.ac.uk/objects/uuid:230fe7b6-31b6-479f-9bd9-b5f6062df8e8
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Autor:
Edfeldt K; Structural Genomics Consortium, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden., Edwards AM; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Engkvist O; Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden & Department of Computer Science and Engineering, Chalmers University of Technology, Gothenburg, Sweden., Günther J; Bayer AG Research and Development, Computational Molecular Design, Berlin, Germany., Hartley M; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK., Hulcoop DG; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.; European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK., Leach AR; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK., Marsden BD; Centre for Medicines Discovery, NDM, University of Oxford, Oxford, UK., Menge A; Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Frankfurt am Main, 60438, Germany & Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Johann Wolfgang Goethe University, Frankfurt am Main, Germany., Misquitta L; National Library of Medicine, National Institutes of Health, Bethesda, MD, USA., Müller S; Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Frankfurt am Main, 60438, Germany & Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Johann Wolfgang Goethe University, Frankfurt am Main, Germany., Owen DR; Pfizer Worldwide Research, Development & Medical, Cambridge, MA, USA., Schütt KT; Pfizer, Worldwide Research, Development and Medical, Machine Learning & Computational Sciences, Berlin, Germany., Skelton N; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA, USA., Steffen A; Pfizer, Worldwide Research, Development and Medical, Machine Learning & Computational Sciences, Berlin, Germany., Tropsha A; Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA., Vernet E; Digital Science & Innovation, Novo Nordisk A/S, Maaloev, Denmark., Wang Y; National Library of Medicine, National Institutes of Health, Bethesda, MD, USA., Wellnitz J; Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA., Willson TM; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Clevert DA; Pfizer, Worldwide Research, Development and Medical, Machine Learning & Computational Sciences, Berlin, Germany. Djork-Arne.Clevert@pfizer.com., Haibe-Kains B; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada. benjamin.haibe.kains@utoronto.ca.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. benjamin.haibe.kains@utoronto.ca.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. benjamin.haibe.kains@utoronto.ca.; Vector Institute for Artificial Intelligence, Toronto, ON, Canada. benjamin.haibe.kains@utoronto.ca., Schiavone LH; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden. Lovisa.Holmberg.Schiavone@astrazeneca.com., Schapira M; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada. matthieu.schapira@utoronto.ca.; Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON, Canada. matthieu.schapira@utoronto.ca.
Publikováno v:
Nature communications [Nat Commun] 2024 Jul 05; Vol. 15 (1), pp. 5640. Date of Electronic Publication: 2024 Jul 05.