Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Marscha, Hirschi"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Animal mitochondrial gene expression relies on specific interactions between nuclear-encoded aminoacyl-tRNA synthetases and mitochondria-encoded tRNAs. Their evolution involves an antagonistic interplay between strong mutation pressure on mt
Externí odkaz:
https://doaj.org/article/1927bea390454aeb94586ab2d058d497
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Mitochondrial tRNAs are indispensable and yet underwent an extreme mutational erosion. The authors report the structures of a mitochondrial aaRS-tRNA complex and show how the most degenerated of all human mtRNAs is recognized by its cognate synthetas
Externí odkaz:
https://doaj.org/article/c61de2c5906644379fa90b8007176bd0
Autor:
Marscha Hirschi, Wang-Ting Lu, Andrew Santiago-Frangos, Royce Wilkinson, Sarah M. Golden, Alan R. Davidson, Gabriel C. Lander, Blake Wiedenheft
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
The anti-CRISPR protein IF9 (AcrIF9) specifically inhibits the type I-F CRISPR adaptive immune system. Here, the authors present the cryo-EM structure of AcrIF9 in complex with the type I-F CRISPR RNA-guided surveillance complex (Csy) and a dsDNA bou
Externí odkaz:
https://doaj.org/article/d3c21875e57643ea9c2043b059ad21af
Autor:
Lejla Zubcevic, Mark A. Herzik, Mengyu Wu, William F. Borschel, Marscha Hirschi, Albert S. Song, Gabriel C. Lander, Seok-Yong Lee
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Transient receptor potential vanilloid channel 3 (TRPV3) responds to temperature and sensitizes upon repeated stimulation with either heat or agonists. Here authors present the cryo-EM structures of apo and sensitized human TRPV3 and describe the str
Externí odkaz:
https://doaj.org/article/2ea7563e099f422d909405e9c45dad14
Autor:
Royce A. Wilkinson, Wang-Ting Lu, Gabriel C. Lander, Sarah Golden, Andrew Santiago-Frangos, Marscha Hirschi, Alan R. Davidson, Blake Wiedenheft
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
Bacteria have evolved sophisticated adaptive immune systems, called CRISPR-Cas, that provide sequence-specific protection against phage infection. In turn, phages have evolved a broad spectrum of anti-CRISPRs that suppress these immune systems. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9efb2cd6872ad952d47cd50dcd6b26
https://doi.org/10.1038/s41467-020-16512-1
https://doi.org/10.1038/s41467-020-16512-1
Autor:
William F. Borschel, Gabriel C. Lander, Marscha Hirschi, Lejla Zubcevic, Mark A. Herzik, Seok-Yong Lee, Mengyu Wu, Albert S. Song
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
Transient receptor potential vanilloid channel 3 (TRPV3), a member of the thermosensitive TRP (thermoTRPV) channels, is activated by warm temperatures and serves as a key regulator of normal skin physiology through the release of pro-inflammatory mes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267025fafc80edd88354362f398046aa
https://doaj.org/article/2ea7563e099f422d909405e9c45dad14
https://doaj.org/article/2ea7563e099f422d909405e9c45dad14
Autor:
Jinhong Wie, Dejian Ren, Yang Suo, Gabriel C. Lander, Marscha Hirschi, Mark A. Herzik, Seok-Yong Lee, William F. Borschel
Publikováno v:
Nature. 550:411-414
A cryo-electron microscopy structure shows that the mucolipin domain of the lysosomal calcium channel TRPML3 binds phosphatidylinositol-3,5-bisphosphate and gates the channel. Numerous ion channels sit in the membranes of intracellular organelles and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::feedd9d844e151167e6d3c5b46547052
https://doi.org/10.1038/nature24055
https://doi.org/10.1038/nature24055
Publikováno v:
Nature
Membrane transporters move substrates across the membrane by alternating access of their binding sites between the opposite sides of the membrane. An emerging model of this process is the elevator mechanism, in which a substrate-binding transport dom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d86185dd3a7f81134c75d763baca01f
http://europepmc.org/articles/PMC5567992
http://europepmc.org/articles/PMC5567992
Autor:
Annemieke Aartsma-Rus, Christa L. de Winter, Laura van Vliet, Sjef J. de Kimpe, Gert-Jan B. van Ommen, Judith C.T. van Deutekom, Anneke A.M. Janson, Hans Heemskerk, Peter A C 't Hoen, Marscha Hirschi
Publikováno v:
Molecular Therapy. 17:548-553
Antisense oligonucleotides (AONs) can interfere with mRNA processing through RNase H-mediated degradation, translational arrest, or modulation of splicing. The antisense approach relies on AONs to efficiently bind to target sequences and depends on A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d253cdf12510783c7d33c1e5999d9fc
https://doi.org/10.1038/mt.2008.205
https://doi.org/10.1038/mt.2008.205
Publikováno v:
Biophysical Journal. 112:22a
Nucleosides are essential molecules for the living cell. As precursors to nucleotides they serve to fuel the salvage pathway of DNA and RNA synthesis. Certain tissues, such as the brain and bone marrow, lack the capacity for de novo synthesis and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16c7c5919cf7e3542e1590a7e654a840
https://doi.org/10.1016/j.bpj.2016.11.155
https://doi.org/10.1016/j.bpj.2016.11.155