An adenoviral-vectored vaccine confers seroprotection against capsular group B meningococcal disease

Autor: Dold, C, Marsay, L, Wang, N, Silva-Reyes, L, Clutterbuck, E, Paterson, GK, Sharkey, K, Wyllie, D, Beernink, PT, Hill, AV, Pollard, AJ, Rollier, CS

Adenoviral-vectored vaccines are licensed for prevention of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Ebola virus, but, for bacterial proteins, expression in a eukaryotic cell may affect the antigen's localization and conformat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::fb7f2ddaff5854b1adad4f9a2f62080b
https://ora.ox.ac.uk/objects/uuid:8c7167e6-a279-48fb-9adf-2d8b3c810cac

Viral vectors expressing group B meningococcal outer membrane proteins induce strong antibody responses but fail to induce functional bactericidal activity

Autor: Marsay, L, Dold, C, Paterson, GK, Yamaguchi, Y, Derrick, JP, Chan, H, Feavers, IM, Maiden, MCJ, Wyllie, D, Hill, AV, Pollard, AJ, Rollier, CS

Publikováno v: Marsay, L, Dold, C, Paterson, G K, Yamaguchi, Y, Derrick, J, Chan, H, Feavers, I M, Maiden, M C J, Wyllie, D, Hill, A V, Pollard, A J & Rollier, C S 2022, ' Viral vectors expressing group B meningococcal outer membrane proteins induce strong antibody responses but fail to induce functional bactericidal activity ', Journal Of Infection, vol. 84, no. 5, pp. 658-667 . https://doi.org/10.1016/j.jinf.2022.02.032
Marsay, L, Dold, C, Paterson, G K, Yamaguchi, Y, Derrick, J P, Chan, H, Feavers, I M, Maiden, M C J, Wyllie, DH, Hill, A V, Pollard, A J & Rollier, C S 2022, ' Viral Vectors Expressing Group B Meningococcal Outer Membrane Proteins Induce Strong Antibody Responses but Fail to Induce Functional Bactericidal Activity in Mice ', Journal of Infection, vol. 84, no. 5, pp. 658-667 . https://doi.org/10.1016/j.jinf.2022.02.032

Objective Adenoviral vectored vaccines, with the appropriate gene insert, induce cellular and antibody responses against viruses, parasites and intracellular pathogens such as Mycobacterium tuberculosis. Here we explored their capacity to induce func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb6b584cbdc35569dbe0a54d7932ea4
https://doi.org/10.1016/j.jinf.2022.02.032

Immunogenicity profiling of protein antigens from capsular group B Neisseria meningitidis

Autor: Awanye, A, Chang, C, Wheeler, J, Chan, H, Marsay, L, Dold, C, Rollier, C, Bird, L, Nettleship, J, Owens, R, Pollard, A, Derrick, J

Publikováno v: Scientific Reports
Awanye, A, Chang, C-M, Wheeler, J X, Chan, H, Marsay, L, Dold, C, Rollier, C S, Bird, L E, Nettleship, J E, Owens, R J, Pollard, A J & Derrick, J 2019, ' Immunogenicity profiling of protein antigens from capsular group B Neisseria meningitidis ', Scientific Reports . https://doi.org/10.1038/s41598-019-43139-0
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)

Outer membrane vesicle (OMV)- based vaccines have been used to provide strain-specific protection against capsular group B Neisseria meningitidis infections, but the full breadth of the immune response against the components of the OMV has not been e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::73e8e4f4aeb7a79d27482a8c35ac62f6
https://pubmed.ncbi.nlm.nih.gov/31048732

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Non-tuberculous mycobacteria have diverse effects on BCG efficacy against Mycobacterium tuberculosis

Autor: Poyntz, H, Stylianou, E, Griffiths, K, Marsay, L, Checkley, A, McShane, H

Publikováno v: Tuberculosis. 94(3)

The efficacy of Bacillus Calmette-Guerin (BCG) vaccination in protection against pulmonary tuberculosis (TB) is highly variable between populations. One possible explanation for this variability is increased exposure of certain populations to non-tub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::719eb6a1e4ba0b75e2b4dcdd61b68024
http://ora.ox.ac.uk/objects/uuid:72c4aa9b-2e86-486c-baf0-1021ce478f54