CSTB gene replacement improves neuroinflammation, neurodegeneration and ataxia in murine type 1 progressive myoclonus epilepsy.

Autor: Gumusgoz E; Division of Neurology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Kasiri S; Division of Neurology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Verma M; Division of Neurology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Wu J; Division of Neurology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Villarreal Acha D; Division of Neurology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Marriam U; Division of Neurology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Fyffe-Maricich S; Ultragenyx, Novato, CA, USA., Lin A; Ultragenyx, Novato, CA, USA., Chen X; Division of Neurology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Gray SJ; Division of Neurology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Minassian BA; Division of Neurology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. berge.minassian@utsouthwestern.edu.

Publikováno v: Gene therapy [Gene Ther] 2024 May; Vol. 31 (5-6), pp. 234-241. Date of Electronic Publication: 2023 Dec 22.

The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer.

Autor: Kim J; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL, USA. jiyeonk@uic.edu., Lee HM; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL, USA., Cai F; Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, TX, USA., Ko B; Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, TX, USA., Yang C; Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, TX, USA., Lieu EL; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL, USA., Muhammad N; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL, USA., Rhyne S; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL, USA., Li K; Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, TX, USA., Haloul M; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL, USA., Gu W; Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, TX, USA., Faubert B; Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, TX, USA., Kaushik AK; Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, TX, USA., Cai L; Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX, USA., Kasiri S; Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA., Marriam U; Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA., Nham K; Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA., Girard L; Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA., Wang H; Oncology Research & Development, Pfizer Inc., San Diego, CA, USA.; Cancer Therapeutics Department, Genomics Institute of the Novartis Research Foundation, San Diego, CA, USA., Sun X; Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA.; Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, USA., Kim J; Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA.; Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Minna JD; Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA.; Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA., Unsal-Kacmaz K; Oncology Research Unit, Pfizer Inc., Pearl River, NY, USA.; Oncology Translational Development, Bristol Myers Squibb, Lawrenceville, NJ, USA., DeBerardinis RJ; Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, TX, USA. Ralph.Deberardinis@UTSouthwestern.edu.; Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA. Ralph.Deberardinis@UTSouthwestern.edu.; McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, TX, USA. Ralph.Deberardinis@UTSouthwestern.edu.; Howard Hughes Medical Institute, UT Southwestern Medical Center, Dallas, TX, USA. Ralph.Deberardinis@UTSouthwestern.edu.

Publikováno v: Nature metabolism [Nat Metab] 2020 Dec; Vol. 2 (12), pp. 1401-1412. Date of Electronic Publication: 2020 Nov 30.

P3.02-073 Stromal Hedgehog Pathway Activation Suppresses Growth and Metastasis of Lung Adenocarcinoma

Autor: Kasiri, S., Chen, B., Wilson, A., Barrie, U., Marriam, U., Zeng, Z., Girard, L., Kim, J.

Publikováno v: In Journal of Thoracic Oncology November 2017 12(11) Supplement 2:S2263-S2264

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Canonical Hedgehog Pathway and Noncanonical GLI Transcription Factor Activation in Cancer.

Autor: Suchors, Chamey¹ (AUTHOR), Kim, James^1,2,3 (AUTHOR) james.kim@utsouthwestern.edu

Publikováno v: Cells (2073-4409). Aug2022, Vol. 11 Issue 16, p2523. 26p.