C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation.

Autor: Manion J; Department of Urology, Boston Children's Hospital, Boston, MA, USA.; Department of Surgery, Harvard Medical School, Boston, MA, USA.; Department of Microbiology, Harvard Medical School, Boston, MA, USA., Musser MA; Division of Gastroenterology, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Kuziel GA; Department of Microbiology, Harvard Medical School, Boston, MA, USA.; Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Liu M; Department of Urology, Boston Children's Hospital, Boston, MA, USA.; Department of Surgery, Harvard Medical School, Boston, MA, USA.; Department of Microbiology, Harvard Medical School, Boston, MA, USA., Shepherd A; Division of Gastroenterology, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Wang S; Department of Urology, Boston Children's Hospital, Boston, MA, USA.; Department of Surgery, Harvard Medical School, Boston, MA, USA.; Department of Microbiology, Harvard Medical School, Boston, MA, USA.; Department of Colorectal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Lee PG; Department of Urology, Boston Children's Hospital, Boston, MA, USA.; Department of Surgery, Harvard Medical School, Boston, MA, USA.; Department of Microbiology, Harvard Medical School, Boston, MA, USA., Zhao L; Department of Urology, Boston Children's Hospital, Boston, MA, USA.; Department of Surgery, Harvard Medical School, Boston, MA, USA.; Department of Microbiology, Harvard Medical School, Boston, MA, USA., Zhang J; Department of Urology, Boston Children's Hospital, Boston, MA, USA.; Department of Surgery, Harvard Medical School, Boston, MA, USA.; Department of Microbiology, Harvard Medical School, Boston, MA, USA., Marreddy RKR; Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX, USA., Goldsmith JD; Department of Pathology, Boston Children's Hospital, Boston, MA, USA., Yuan K; Division of Pulmonary Medicine, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Hurdle JG; Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX, USA., Gerhard R; Institute of Toxicology, Hannover Medical School, Hannover, Germany., Jin R; Department of Physiology and Biophysics, School of Medicine, University of California Irvine, Irvine, CA, USA., Rakoff-Nahoum S; Department of Microbiology, Harvard Medical School, Boston, MA, USA.; Division of Gastroenterology, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.; Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Rao M; Division of Gastroenterology, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. meenakshi.rao@childrens.harvard.edu., Dong M; Department of Urology, Boston Children's Hospital, Boston, MA, USA. min.dong@childrens.harvard.edu.; Department of Surgery, Harvard Medical School, Boston, MA, USA. min.dong@childrens.harvard.edu.; Department of Microbiology, Harvard Medical School, Boston, MA, USA. min.dong@childrens.harvard.edu.

Publikováno v: Nature [Nature] 2023 Oct; Vol. 622 (7983), pp. 611-618. Date of Electronic Publication: 2023 Sep 12.

The early stage peptidoglycan biosynthesis Mur enzymes are antibacterial and antisporulation drug targets for recurrent Clostridioides difficile infection.

Autor: Sapkota M; University of Texas at Arlington, Department of Biology, Arlington, TX, 76019, United States., Marreddy RKR; Texas A & M University Health Science Center, Biosciences and Technology, Houston, TX, 77030, United States., Wu X; Texas A & M University Health Science Center, Biosciences and Technology, Houston, TX, 77030, United States., Kumar M; University of Texas at Arlington, Department of Biology, Arlington, TX, 76019, United States., Hurdle JG; Texas A & M University Health Science Center, Biosciences and Technology, Houston, TX, 77030, United States. Electronic address: jhurdle@tamu.edu.

Publikováno v: Anaerobe [Anaerobe] 2020 Feb; Vol. 61, pp. 102129. Date of Electronic Publication: 2019 Nov 21.

The Fatty Acid Synthesis Protein Enoyl-ACP Reductase II (FabK) is a Target for Narrow-Spectrum Antibacterials for Clostridium difficile Infection.

Autor: Marreddy RKR; Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology , Texas A&M Health Science Center , 2121 West Holcombe Boulevard , Houston , Texas 77030 , United States., Wu X; Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology , Texas A&M Health Science Center , 2121 West Holcombe Boulevard , Houston , Texas 77030 , United States., Sapkota M; Department of Biology , University of Texas Arlington , 701 West Nedderman Drive , Arlington , Texas 76019 , United States., Prior AM; Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy , University of Hawaii at Hilo , 34 Rainbow Drive , Hilo , Hawaii 96720 , United States., Jones JA; Department of Pharmaceutical Sciences, College of Pharmacy , University of Tennessee Health Science Center , 881 Madison Avenue , Memphis , Tennessee 38105 , United States., Sun D; Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy , University of Hawaii at Hilo , 34 Rainbow Drive , Hilo , Hawaii 96720 , United States., Hevener KE; Department of Pharmaceutical Sciences, College of Pharmacy , University of Tennessee Health Science Center , 881 Madison Avenue , Memphis , Tennessee 38105 , United States., Hurdle JG; Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology , Texas A&M Health Science Center , 2121 West Holcombe Boulevard , Houston , Texas 77030 , United States.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2019 Feb 08; Vol. 5 (2), pp. 208-217. Date of Electronic Publication: 2018 Dec 13.

Biophysical characterization of E. coli TolC interaction with the known blocker hexaamminecobalt.

Autor: Gilardi A; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Department Screening Port, Schnackenburgallee 114, 22525 Hamburg, Germany; Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany., Bhamidimarri SP; Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany., Brönstrup M; Helmholtz Centre for Infection Research and German Center for Infection Research (DZIF), Inhoffenstraße 7, 38124 Braunschweig, Germany., Bilitewski U; Helmholtz Centre for Infection Research and German Center for Infection Research (DZIF), Inhoffenstraße 7, 38124 Braunschweig, Germany., Marreddy RKR; Goethe University Frankfurt, Institute of Biochemistry, Max-von-Laue-Straße 9, 60438 Frankfurt, Germany., Pos KM; Goethe University Frankfurt, Institute of Biochemistry, Max-von-Laue-Straße 9, 60438 Frankfurt, Germany., Benier L; Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany., Gribbon P; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Department Screening Port, Schnackenburgallee 114, 22525 Hamburg, Germany., Winterhalter M; Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany., Windshügel B; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Department Screening Port, Schnackenburgallee 114, 22525 Hamburg, Germany. Electronic address: bjoern.windshuegel@ime.fraunhofer.de.

Publikováno v: Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2017 Nov; Vol. 1861 (11 Pt A), pp. 2702-2709. Date of Electronic Publication: 2017 Jul 23.