Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Marquis P, Vawter"'
Autor:
Audrey A. Omidsalar, Carmel G. McCullough, Lili Xu, Stanley Boedijono, Daniel Gerke, Michelle G. Webb, Zarko Manojlovic, Adolfo Sequeira, Mark F. Lew, Marco Santorelli, Geidy E. Serrano, Thomas G. Beach, Agenor Limon, Marquis P. Vawter, Brooke E. Hjelm
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-20 (2024)
Abstract Common mitochondrial DNA (mtDNA) deletions are large structural variants in the mitochondrial genome that accumulate in metabolically active tissues with age and have been investigated in various diseases. We applied the Splice-Break2 pipeli
Externí odkaz:
https://doaj.org/article/b606b4bfef3147a49f38ed1db08b12ca
Autor:
Adriana M. Medina, Megan Hastings Hagenauer, David M. Krolewski, Evan Hughes, Liam Cannon Thew Forrester, David M. Walsh, Maria Waselus, Evelyn Richardson, Cortney A. Turner, P. Adolfo Sequeira, Preston M. Cartagena, Robert C. Thompson, Marquis P. Vawter, Blynn G. Bunney, Richard M. Myers, Jack D. Barchas, Francis S. Lee, Alan F. Schatzberg, William E. Bunney, Huda Akil, Stanley J. Watson
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The frontal pole (Brodmann area 10, BA10) is the largest cytoarchitectonic region of the human cortex, performing complex integrative functions. BA10 undergoes intensive adolescent grey matter pruning prior to the age of onset for bipolar di
Externí odkaz:
https://doaj.org/article/ecdaa6095ceb4f37b0d1e6facf90baf0
Autor:
Anton Schulmann, Stefano Marenco, Marquis P. Vawter, Nirmala Akula, Agenor Limon, Ajeet Mandal, Pavan K. Auluck, Yash Patel, Barbara K. Lipska, Francis J. McMahon
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Recent postmortem transcriptomic studies of schizophrenia (SCZ) have shown hundreds of differentially expressed genes. However, the extent to which these gene expression changes reflect antipsychotic drug (APD) exposure remains uncertain. We
Externí odkaz:
https://doaj.org/article/6c8d3909b4f74186bcb9e6b84c0ae689
Autor:
Sujan C. Das, Brooke E. Hjelm, Brandi L. Rollins, Adolfo Sequeira, Ling Morgan, Audrey A. Omidsalar, Alan F. Schatzberg, Jack D. Barchas, Francis S. Lee, Richard M. Myers, Stanley J. Watson, Huda Akil, William E. Bunney, Marquis P. Vawter
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Mitochondrial dysfunction is a neurobiological phenomenon implicated in the pathophysiology of schizophrenia and bipolar disorder that can synergistically affect synaptic neurotransmission. We hypothesized that schizophrenia and bipolar diso
Externí odkaz:
https://doaj.org/article/6f2dcb64f3264a568f9d012a75e13127
Autor:
Firoza Mamdani, Matthieu D. Weber, Blynn Bunney, Kathleen Burke, Preston Cartagena, David Walsh, Francis S. Lee, Jack Barchas, Alan F. Schatzberg, Richard M. Myers, Stanley J. Watson, Huda Akil, Marquis P. Vawter, William E. Bunney, Adolfo Sequeira
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Suicides have increased to over 48,000 deaths yearly in the United States. Major depressive disorder (MDD) is the most common diagnosis among suicides, and identifying those at the highest risk for suicide is a pressing challenge. The object
Externí odkaz:
https://doaj.org/article/14687cc533e84d7586bd3f5377770ca1
Autor:
Ryne C. Ramaker, Kevin M. Bowling, Brittany N. Lasseigne, Megan H. Hagenauer, Andrew A. Hardigan, Nicholas S. Davis, Jason Gertz, Preston M. Cartagena, David M. Walsh, Marquis P. Vawter, Edward G. Jones, Alan F. Schatzberg, Jack D. Barchas, Stanley J. Watson, Blynn G. Bunney, Huda Akil, William E. Bunney, Jun Z. Li, Sara J. Cooper, Richard M. Myers
Publikováno v:
Genome Medicine, Vol 9, Iss 1, Pp 1-12 (2017)
Abstract Background Psychiatric disorders are multigenic diseases with complex etiology that contribute significantly to human morbidity and mortality. Although clinically distinct, several disorders share many symptoms, suggesting common underlying
Externí odkaz:
https://doaj.org/article/29db10a441b94b67924cb7c4510ec9e2
Autor:
Brooke E. Hjelm, Christian Ramiro, Brandi L. Rollins, Audrey A. Omidsalar, Daniel S. Gerke, Sujan C. Das, Adolfo Sequeira, Ling Morgan, Alan F. Schatzberg, Jack D. Barchas, Francis S. Lee, Richard M. Myers, Stanley J. Watson, Huda Akil, William E. Bunney, Marquis P. Vawter
Publikováno v:
Complex Psychiatry. 8:90-98
Introduction: Large somatic deletions of mitochondrial DNA (mtDNA) accumulate with aging in metabolically active tissues such as the brain. We have cataloged the breakpoints and frequencies of large mtDNA deletions in the human brain. Methods: We qua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f5fa7b56fed0a2f8db6b3bded373318
https://doi.org/10.1159/000528051
https://doi.org/10.1159/000528051
Autor:
Megan Hastings Hagenauer, Anton Schulmann, Jun Z Li, Marquis P Vawter, David M Walsh, Robert C Thompson, Cortney A Turner, William E Bunney, Richard M Myers, Jack D Barchas, Alan F Schatzberg, Stanley J Watson, Huda Akil
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200003 (2018)
Psychiatric illness is unlikely to arise from pathology occurring uniformly across all cell types in affected brain regions. Despite this, transcriptomic analyses of the human brain have typically been conducted using macro-dissected tissue due to th
Externí odkaz:
https://doaj.org/article/e26fb372fbc249d7993d47c5427fe359
Autor:
Vanessa F Gonçalves, Stephanie N Giamberardino, James J Crowley, Marquis P Vawter, Richa Saxena, Cynthia M Bulik, Zeynep Yilmaz, Christina M Hultman, Pamela Sklar, James L Kennedy, Patrick F Sullivan, Jo Knight
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191153 (2018)
Oxidative phosphorylation within mitochondria is the main source of aerobic energy for neuronal functioning, and the key genes are located in mitochondrial DNA. Deficits in oxidative phosphorylation functioning have been reported for schizophrenia, b
Externí odkaz:
https://doaj.org/article/b43b5d9ae3864a55945f432d69104ef7
Autor:
Richard Stein, Firoza Mamdani, Blynn Bunney, Preston Cartagena, Marquis P. Vawter, Alan F. Schatzberg, Jack Barchas, Francis S. Lee, Richard Myers, Stanley J. Watson, Huda Akil, William E. Bunney, Adolfo Sequeira
The effects of smoking in the human brain were explored at the molecular level in the nucleus accumbens(NAcc), a key brain region involved in tobacco addiction. Gene expression data from post-mortem NAcc were analyzed according to smoking habits: Nev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af105072df9a86c823935b38f4c9a0a5
https://doi.org/10.1101/2022.09.30.22280587
https://doi.org/10.1101/2022.09.30.22280587
