Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Marpadga A. Reddy"'
Autor:
Marpadga A. Reddy, Vishnu Amaram, Sadhan Das, Vinay Singh Tanwar, Rituparna Ganguly, Mei Wang, Linda Lanting, Lingxiao Zhang, Maryam Abdollahi, Zhuo Chen, Xiwei Wu, Sridevi Devaraj, Rama Natarajan
Publikováno v:
JCI Insight, Vol 6, Iss 11 (2021)
Long noncoding RNAs (lncRNAs) are increasingly implicated in the pathology of diabetic complications. Here, we examined the role of lncRNAs in monocyte dysfunction and inflammation associated with human type 2 diabetes mellitus (T2D). RNA sequencing
Externí odkaz:
https://doaj.org/article/5f467a5642364bdc98a43bb2b160a7be
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Chronic metabolic disorders such as obesity and diabetes are associated with accelerated rates of macrovascular and microvascular complications, which are leading causes of morbidity and mortality worldwide. Further understanding of the underlying mo
Externí odkaz:
https://doaj.org/article/46ebb37f944740efb8a633741d8dd5db
Autor:
Sadhan Das, Parijat Senapati, Zhuo Chen, Marpadga A. Reddy, Rituparna Ganguly, Linda Lanting, Varun Mandi, Anita Bansal, Amy Leung, Selena Zhang, Ye Jia, Xiwei Wu, Dustin E. Schones, Rama Natarajan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
The repertoire of tissue-specific distal regulators of gene transcription enhancers defines homeostasis or disease. Here, the authors reveal the enhancer and super-enhancer signature of vascular smooth muscle cells under normal and angiotensin II sti
Externí odkaz:
https://doaj.org/article/c12c799c38c64e36a32adeb8061e24ec
Autor:
Vishnu Amaram Samara, Sadhan Das, Marpadga A. Reddy, Vinay Singh Tanwar, Kenneth Stapleton, Amy Leung, Maryam Abdollahi, Rituparna Ganguly, Linda Lanting, Rama Natarajan
Publikováno v:
Cells, Vol 10, Iss 10, p 2696 (2021)
Long non-coding RNAs (lncRNAs) play key roles in Angiotensin II (AngII) signaling but their role in chondrogenic transformation of vascular smooth muscle cells (VSMCs) is unknown. We describe a novel AngII-induced lncRNA Alivec (Angiotensin II-induce
Externí odkaz:
https://doaj.org/article/bf30d0f40d4f4e429a491aaf3b6ff8e0
Publikováno v:
Kidney Research and Clinical Practice, Vol 31, Iss 3, Pp 139-150 (2012)
Diabetic nephropathy (DN) is a major complication associated with both type 1 and type 2 diabetes, and a leading cause of end-stage renal disease. Conventional therapeutic strategies are not fully efficacious in the treatment of DN, suggesting an inc
Externí odkaz:
https://doaj.org/article/1ff19bd9a2044adbbdc4c8da9a6c4982
Autor:
Vinay Singh Tanwar, Marpadga A. Reddy, Sadhan Das, Vishnu Amaram Samara, Maryam Abdollahi, Suchismita Dey, Vajir Malek, Rituparna Ganguly, Kenneth Stapleton, Linda Lanting, Patrick Pirrotte, Rama Natarajan
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology.
Background: Obesity and diabetes are associated with elevated free fatty acids like palmitic acid (PA), which promote chronic inflammation and impaired inflammation resolution associated with cardiometabolic disorders. Long noncoding RNAs (lncRNAs) a
Autor:
VINAY S. TANWAR, MARPADGA A. REDDY, SADHAN DAS, VISHNU AMARAM SAMARA, MARYAM ABDOLLAHI, SUCHISMITA DEY, RITUPARNA GANGULY, LINDA L. LANTING, KENNETH STAPLETON, RAMA NATARAJAN
Publikováno v:
Diabetes. 71
Obesity and diabetes are associated with chronic inflammation induced by the elevated circulating levels of Palmitic acid (PA) and also result from impaired resolution of inflammation in macrophages. Here, we examined the role of PA-induced long non-
Autor:
MARPADGA A. REDDY, VINAY S. TANWAR, LINGXIAO ZHANG, LINDA L. LANTING, MEI WANG, PRIYATAMA PANDEY, ZHUO CHEN, XIWEI WU, RAMA NATARAJAN
Publikováno v:
Diabetes. 71
The activation of monocytes and macrophages plays a central role in chronic inflammation associated with type 2 diabetes mellitus (T2D) and cardiovascular disease. However, the precise epigenetic mechanisms involved are unclear. From RNA-seq analysis
Publikováno v:
Curr Opin Cardiol
Purpose of review Hyperlipidemia, hypertension, diabetes and related metabolic disorders increase the risk for cardiovascular disease (CVD). Despite significant progress in the identification of key mechanisms and genetic polymorphisms linked to vari
Autor:
Rengasamy Palanivel, Rama Natarajan, Lingxiao Zhang, Vishnu Amaram, Jeffrey A. Deiuliis, Kenneth Stapleton, Zhuo Chen, Linda Lanting, Marpadga A. Reddy, Sadhan Das, Amy Leung
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 40:914-928
Objective: Systemic low-grade inflammation associated with obesity and metabolic syndrome is a strong risk factor for the development of diabetes mellitus and associated cardiovascular complications. This inflammatory state is caused by release of pr