Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Maroya D. Spalding"'
Autor:
Maroya D Spalding, Sean T Prigge
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7392 (2009)
BACKGROUND:In the 1950s, Reed and coworkers discovered an enzyme activity in Streptococcus faecalis (Enterococcus faecalis) extracts that inactivated the Escherichia. coli and E. faecalis pyruvate dehydrogenase complexes through cleavage of the lipoa
Externí odkaz:
https://doaj.org/article/d51259a79bd94f6c86ece80476533d5b
Autor:
Sean T. Prigge, Maroya D. Spalding
Publikováno v:
Microbiology and Molecular Biology Reviews. 74:200-228
SUMMARY Lipoic acid [( R )-5-(1,2-dithiolan-3-yl)pentanoic acid] is an enzyme cofactor required for intermediate metabolism in free-living cells. Lipoic acid was discovered nearly 60 years ago and was shown to be covalently attached to proteins in se
Autor:
Josephine A. Czechowicz, David G. Alberg, Anna M. Larson, Maroya D. Spalding, Linnea K. Engel, April K. Wilhelm
Publikováno v:
The Journal of Organic Chemistry. 72:3689-3693
Trypanothione reductase (TR) catalyzes the NADPH-dependent reduction of trypanothione disulfide (1). TR plays a central role in the trypanosomatid parasite's defense against oxidative stress and has emerged as a promising target for antitrypanosomal
Publikováno v:
The FASEB Journal. 29
Lipoate is an organosulfur cofactor that participates in several, well-conserved metabolic pathways in malaria parasites. The mitochondrial proteins of Plasmodium are lipoylated through the uptake ...
Autor:
Sean T. Prigge, Maroya D. Spalding
Publikováno v:
Cell Host & Microbe. 4:509-511
Fatty acid biosynthesis has been viewed as an important biological function of and therapeutic target for Plasmodium falciparum asexual blood stage infection. This apicoplast-resident type II pathway, distinct from the mammalian type I process, inclu
Autor:
Norman C. Waters, Sean T. Prigge, Sheryl A. Bedno, Rodney L. Coldren, Maroya D. Spalding, William J. Moss, Hoseah M Akala, Fredrick Eyase
Publikováno v:
Malaria Journal
Malaria Journal, Vol 9, Iss 1, p 338 (2010)
Malaria Journal, Vol 9, Iss 1, p 338 (2010)
Background Anti-malarial drug resistance in Kenya prompted two drug policy changes within a decade: sulphadoxine-pyrimethamine (SP) replaced chloroquine (CQ) as the first-line anti-malarial in 1998 and artemether-lumefantrine (AL) replaced SP in 2004
Publikováno v:
BMC Biotechnology, Vol 10, Iss 1, p 73 (2010)
BMC Biotechnology
BMC Biotechnology
Background Biotin is an essential enzyme cofactor that acts as a CO2 carrier in carboxylation and decarboxylation reactions. The E. coli genome encodes a biosynthetic pathway that produces biotin from pimeloyl-CoA in four enzymatic steps. The final s
The glycine cleavage complex (GCV) is a potential source of the one carbon donor 5,10-methylene-tetrahydrofolate (5,10-CH 2 -THF) in the malaria parasite Plasmodium falciparum . One carbon (C1) donor units are necessary for amino acid and nucleotide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caaf62f0a4cf8a11010c622e16ff0388
https://europepmc.org/articles/PMC2875341/
https://europepmc.org/articles/PMC2875341/
Autor:
Sean T. Prigge, Maroya D. Spalding
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7392 (2009)
PLoS ONE
PLoS ONE
BACKGROUND:In the 1950s, Reed and coworkers discovered an enzyme activity in Streptococcus faecalis (Enterococcus faecalis) extracts that inactivated the Escherichia. coli and E. faecalis pyruvate dehydrogenase complexes through cleavage of the lipoa