Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Marouan Abouhamed"'
Publikováno v:
American Journal of Physiology-Renal Physiology. 309:F501-F513
Mammalian class IX myosin Myo9a is a single-headed, actin-dependent motor protein with Rho GTPase-activating protein activity that negatively regulates Rho GTPase signaling. Myo9a is abundantly expressed in ciliated epithelial cells of several organs
Autor:
Marouan Abouhamed, Martin Bähler, Karl Matter, Sabine Thelen, Kay Grobe, Isabelle V. Leefa Chong San, Ulrike Honnert, Maria S. Balda
Publikováno v:
Molecular Biology of the Cell. 20:5074-5085
The ependymal multiciliated epithelium in the brain restricts the cerebrospinal fluid to the cerebral ventricles and regulates its flow. We report here that mice deficient for myosin IXa (Myo9a), an actin-dependent motor molecule with a Rho GTPase–
Publikováno v:
American Journal of Physiology-Renal Physiology. 291:F823-F832
The nephrotoxic metal cadmium at micromolar concentrations induces apoptosis of rat kidney proximal tubule (PT) cells within 3-6 h of exposure. The underlying cell death pathways remain poorly defined. Using Hoechst 33342/ethidium bromide nuclear sta
Autor:
Wei Liu, Natascha A. Wolff, Andreas Wilhelm, Marouan Abouhamed, Jakub Gburek, Craig P. Smith, Erik Ilsø Christensen, Frank Thévenod, Blazej Torchalski
Publikováno v:
Abouhamed, M, Gburek, J, Liu, W, Torchalski, B, Wilhelm, A, Wolff, NA, Christensen, E I, Thevenod, F & Smith, CP 2006, ' Divalent Metal Transporter 1 in the Kidney Proximal Tubule is Expressed in Late Endosomes/Lysosomal Membranes: Implications for Renal Handling of Protein-Metal Complexes ', American Journal of Physiology: Renal Physiology, vol. 290, no. 6, pp. F1525-F1533 .
The H+-coupled polyligand transport protein divalent metal transporter 1 (DMT1) plays a key role in mammalian iron homeostasis. It has a widespread pattern of expression including tissues associated with iron acquisition and storage. Interestingly, i
Publikováno v:
European Journal of Cell Biology. 82:473-482
Dedifferentiation of smooth muscle cells (SMC) from the contractile to the synthetic phenotype is a key event in atherosclerosis. A comparable phenotypic change from the contractile to the synthetic state is rapidly incurred when SMC are grown in cul
Publikováno v:
The FASEB Journal. 22
Publikováno v:
Toxicology and applied pharmacology. 230(1)
Filtered metal-protein complexes, such as cadmium-metallothionein-1 (CdMT-1) or transferrin (Tf) are apically endocytosed partly via megalin/cubilin by kidney proximal tubule (PT) cells where CdMT-1 internalization causes apoptosis. Small GTPase ARF
Publikováno v:
American journal of physiology. Renal physiology. 293(3)
Chronic exposure to Cd2+ causes renal proximal tubular (PT) damage. Cd2+ reaches the PT mainly as cadmium-metallothionein 1 (CdMT-1) complexes that are filtered at the glomerulus and then internalized in part via endocytosis mediated by megalin and c
Publikováno v:
The FASEB Journal. 21
Publikováno v:
Molecular biology of the cell. 18(4)
Myosin IXb (Myo9b) is a single-headed processive myosin that exhibits Rho GTPase-activating protein (RhoGAP) activity in its tail region. Using live cell imaging, we determined that Myo9b is recruited to extending lamellipodia, ruffles, and filopodia