Zobrazeno 1 - 10 of 43 pro vyhledávání: '"Marole M. Maluleka"'
1
Akademický článek
Synthesis, crystal structure, cytotoxicity (MCF-7 and HeLa) and free radical scavenging activity of the hydrazones derived from 2-methylsulfonyl-5-nitrobenzaldehyde
Autor: Marole M. Maluleka, Malose J. Mphahlele
Publikováno v: Results in Chemistry, Vol 12, Iss , Pp 101896- (2024)
The rising levels of breast and cervical cancers among women have become public health problem with high economic burden globally and more especially in low- and middle-income countries. This necessitates discoving new and potent anticancer drugs wit
Externí odkaz: https://doaj.org/article/86c9db31ac04426a87b56ab57ae905a0
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2
Akademický článek
Synthesis, Conformational Analysis and Evaluation of the 2-aryl-4-(4-bromo-2-hydroxyphenyl)benzo[1,5]thiazepines as Potential α-Glucosidase and/or α-Amylase Inhibitors
Autor: Jackson K. Nkoana, Marole M. Maluleka, Malose J. Mphahlele, Richard M. Mampa, Yee Siew Choong
Publikováno v: Molecules, Vol 27, Iss 20, p 6935 (2022)
The ambident electrophilic character of the 5-bromo-2-hydroxychalcones and the binucleophilic nature of 2-aminothiophenol were exploited to construct the 2-aryl-4-(4-bromo-2-hydroxyphenyl)benzo[1,5]thiazepines. The structures and conformation of thes
Externí odkaz: https://doaj.org/article/a2e6b44a2a0c469eaa74cc93dc520df0
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3
Akademický článek
Benzofuran–appended 4-aminoquinazoline hybrids as epidermal growth factor receptor tyrosine kinase inhibitors: synthesis, biological evaluation and molecular docking studies
Autor: Malose J. Mphahlele, Marole M. Maluleka, Abimbola Aro, Lyndy J. McGaw, Yee Siew Choong
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1516-1528 (2018)
A series of 2-arylbenzo[b]furan–appended 4-aminoquinazoline hybrids were prepared and evaluated for cytotoxicity in vitro against the human lung cancer (A549), colorectal adenocarcinoma (Caco-2), hepatocellular carcinoma (C3A) and cervical cancer (
Externí odkaz: https://doaj.org/article/3e7d4bce138141f6b0604661811a732a
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4
Akademický článek
Spectroscopic, X-ray Diffraction and Density Functional Theory Study of Intra- and Intermolecular Hydrogen Bonds in Ortho-(4-tolylsulfonamido)benzamides
Autor: Malose J. Mphahlele, Eugene E. Onwu, Marole M. Maluleka
Publikováno v: Molecules, Vol 26, Iss 4, p 926 (2021)
The conformations of the title compounds were determined in solution (NMR and UV-Vis spectroscopy) and in the solid state (FT-IR and XRD), complemented with density functional theory (DFT) in the gas phase. The nonequivalence of the amide protons of
Externí odkaz: https://doaj.org/article/1a28dfd69b3146f5b459dfc90193c2b0
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5
Akademický článek
Synthesis, In Vitro Evaluation and Molecular Docking of the 5-Acetyl-2-aryl-6-hydroxybenzo[b]furans against Multiple Targets Linked to Type 2 Diabetes
Autor: Malose J. Mphahlele, Yee Siew Choong, Marole M. Maluleka, Samantha Gildenhuys
Publikováno v: Biomolecules, Vol 10, Iss 3, p 418 (2020)
The 5-acetyl-2-aryl-6-hydroxybenzo[b]furans 2a−h have been evaluated through in vitro enzymatic assay against targets which are linked to type 2 diabetes (T2D), namely, α-glucosidase, protein tyrosine phosphatase 1B (PTP1B) and β-secretase. These
Externí odkaz: https://doaj.org/article/6b4c28bc5bcc4bf8932bb99671af9b20
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6
Akademický článek
Elucidation of the Structure of the 2-amino-3,5-Dibromochalcone Epoxides in Solution and Solid State
Autor: Malose J. Mphahlele, Marole M. Maluleka, Richard M. Mampa
Publikováno v: Crystals, Vol 9, Iss 6, p 277 (2019)
The conformation of the title compounds was determined in solution by 1H-NMR spectroscopy and in solid state by single-crystal X-ray diffraction (XRD) complemented with density functional theory. The compounds were found to exist exclusively in solut
Externí odkaz: https://doaj.org/article/40f0251b10df4d96ba99574ad9610202
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8
Synthesis, in vitro and in silico enzyme (COX-1/2 & LOX-5), free radical scavenging and cytotoxicity profiling of the 2,4-dicarbo substituted quinazoline 3-oxides
Autor: Marole M. Maluleka, Eugene E. Onwu, Garland K. More, Emmanuel N Agbo, Yee Siew Choong, Malose J. Mphahlele
Publikováno v: Medicinal Chemistry Research. 31:146-164
Series of the 3-methylquinazoline 3-oxide derivatives were evaluated through enzymatic assays in vitro and in silico for potential inhibitory effect against cyclooxygenase-1/2 (COX-1/2) and lipoxygenase-5 activities as well as for free radical scaven
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0dc8aae2ee6b7fd92702c698ea7aca5f
https://doi.org/10.1007/s00044-021-02811-9
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9
Crystal structure of 6-bromo-2-(4-chlorophenyl)chroman-4-one (6-bromo-4′-chloroflavanone), C15H10BrClO2
Autor: Marole M. Maluleka, Malose J. Mphahlele
Publikováno v: Zeitschrift für Kristallographie - New Crystal Structures. 237:475-477
C15H10BrClO2 monoclinic P21/c (no. 14), a = 9.2173(6) Å, b = 20.7174(14) Å, c = 6.9035(4) Å, β = 99.332(3)°, V = 1300.83(14) Å3, Z = 4, Rgt (F) = 0.0153, wRref (F 2) = 0.121, T = 173(2) K.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1424ee8672852f0ba53c1ab760b4523a
https://doi.org/10.1515/ncrs-2022-0104
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10
Crystal structure of (E)-1-(2–nitrophenyl)-3-phenylprop-2-en-1-one, C15H11NO3
Autor: Marole M Maluleka, Malose J Mphahlele
Publikováno v: Zeitschrift für Kristallographie - New Crystal Structures. 237:351-353
C15H11NO3, P21/c (no. 14), a = 5.4092(2) Å, b = 23.9605(8) Å, c = 9.4887(3) Å, β = 96.080(1)°, V = 1222.89(7) Å3, Z = 4, R gt(F) = 0.0358, wR ref(F 2) = 0.0888, T = 173(2) K.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0b7c94b923c3e380d789e29a4d7282d
https://doi.org/10.1515/ncrs-2022-0032
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