Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Marnix R, Jonker"'
Autor:
Qing Chen, Kingsley Okechukwu Nwozor, Maarten van den Berge, Dirk-Jan Slebos, Alen Faiz, Marnix R. Jonker, H. Marike Boezen, Irene H. Heijink, Maaike de Vries
Publikováno v:
Cells, Vol 11, Iss 21, p 3423 (2022)
Cigarette smoking causes hypomethylation of the gene Aryl Hydrocarbon Receptor Repressor (AHRR), which regulates detoxification and oxidative stress-responses. We investigated whether AHRR DNA methylation is related to chronic obstructive pulmonary d
Externí odkaz:
https://doaj.org/article/8bd946d3f36e4d89bc588c6f8a00ad14
Autor:
Gwenda F. Vasse, Lisette Van Os, Marina De Jager, Marnix R. Jonker, Theo Borghuis, L. Tim Van Den Toorn, Pytrick Jellema, Eric S. White, Patrick Van Rijn, Martin C. Harmsen, Irene H. Heijink, Barbro N. Melgert, Janette K. Burgess
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Introduction: Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease characterized by excess deposition and altered structure of extracellular matrix (ECM) in the lungs. The fibrotic ECM is paramount in directing resident cells toward a profi
Externí odkaz:
https://doaj.org/article/2ad3140a7bce4d829fc6429caec51692
Autor:
Elizabeth K. Marsh, Elizabeth C. Prestwich, Lynne Williams, Amber R. Hart, Clare F. Muir, Lisa C. Parker, Marnix R. Jonker, Irene H. Heijink, Wim Timens, Mark Fife, Tracy Hussell, Marc B. Hershenson, J. Kelley Bentley, Shao-Cong Sun, Ben S. Barksby, Lee A. Borthwick, James P. Stewart, Ian Sabroe, David H. Dockrell, Helen M. Marriott
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Exposure to respiratory pathogens is a leading cause of exacerbations of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD). Pellino-1 is an E3 ubiquitin ligase known to regulate virally-induced inflammation. We wished to
Externí odkaz:
https://doaj.org/article/c5942d2d51cf4be9955c03b1925a6bc9
Autor:
Ilse M. Boudewijn, Alen Faiz, Katrina Steiling, Erica van der Wiel, Eef D. Telenga, Susan J. M. Hoonhorst, Nick H. T. ten Hacken, Corry-Anke Brandsma, Huib A. M. Kerstjens, Wim Timens, Irene H. Heijink, Marnix R. Jonker, Harold G. de Bruin, J. Sebastiaan Vroegop, Henk R. Pasma, Wim G. Boersma, Pascal Wielders, Frank van den Elshout, Khaled Mansour, Avrum Spira, Marc E. Lenburg, Victor Guryev, Dirkje S. Postma, Maarten van den Berge
Publikováno v:
Respiratory Research, Vol 18, Iss 1, Pp 1-10 (2017)
Abstract Background Nasal gene expression profiling is a promising method to characterize COPD non-invasively. We aimed to identify a nasal gene expression profile to distinguish COPD patients from healthy controls. We investigated whether this COPD-
Externí odkaz:
https://doaj.org/article/65ad28ccc1de4dada65462a59303ada5
Autor:
Dennis M. L. W. Kruk, Marissa Wisman, Jacobien A. Noordhoek, Mehmet Nizamoglu, Marnix R. Jonker, Harold G. de Bruin, Karla Arevalo Gomez, Nick H. T. ten Hacken, Simon D. Pouwels, Irene H. Heijink
Publikováno v:
Cells, Vol 10, Iss 11, p 2860 (2021)
COPD is characterized by irreversible lung tissue damage. We hypothesized that lung-derived mesenchymal stromal cells (LMSCs) reduce alveolar epithelial damage via paracrine processes, and may thus be suitable for cell-based strategies in COPD. We ai
Externí odkaz:
https://doaj.org/article/c260538f10634f8fb47eb09a8a7cee22
Autor:
Martin C. Harmsen, Machteld N. Hylkema, M Roobeek, Prashant K. Sharma, Janette K. Burgess, R.H.J. de Hilster, Wim Timens, Eric S. White, Marnix R. Jonker, E A Gercama
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology, 318(4), L698-L704. AMER PHYSIOLOGICAL SOC
American Journal of Physiology-Lung Cellular and Molecular Physiology
American Journal of Physiology-Lung Cellular and Molecular Physiology
Chronic lung diseases such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) are associated with changes in extracellular matrix (ECM) composition and abundance affecting the mechanical properties of the lung. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4fb8a392bcdb9040480eb6ca1dbf2e
https://doi.org/10.1152/ajplung.00451.2019
https://doi.org/10.1152/ajplung.00451.2019
Autor:
Darryl A. Knight, Jacobien A. Noordhoek, Marnix R. Jonker, Harold G. de Bruin, Virinchi N. S. Kuchibhotla, Irene H. Heijink, Martijn C. Nawijn
Publikováno v:
Allergy, 75(7), 1786-1789. Wiley-Blackwell
Allergy
Allergy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a68522cacb8a447807df20a2afd18b
https://doi.org/10.1111/all.14216
https://doi.org/10.1111/all.14216
Autor:
Mehmet Nizamoglu, Marnix R. Jonker, Harold G. de Bruin, Simon D. Pouwels, Dennis M L W Kruk, Karla F. Arevalo Gomez, Marissa Wisman, Jacobien A. Noordhoek, Nick H. T. ten Hacken, Irene H. Heijink
Publikováno v:
Cells
Volume 10
Issue 11
Cells, 10(11):2860. MDPI AG
Cells, Vol 10, Iss 2860, p 2860 (2021)
Volume 10
Issue 11
Cells, 10(11):2860. MDPI AG
Cells, Vol 10, Iss 2860, p 2860 (2021)
COPD is characterized by irreversible lung tissue damage. We hypothesized that lung-derived mesenchymal stromal cells (LMSCs) reduce alveolar epithelial damage via paracrine processes, and may thus be suitable for cell-based strategies in COPD. We ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2b21d393440b2a43f058165f183036
Autor:
Marnix R. Jonker, Olga Danov, Gesine Hansen, U. R. Juergens, M Van De Berge, Anna-Maria Dittrich, D.J. Leeming, Morten A. Karsdal, Brian G. Oliver, Ulrich M. Zissler, Michael Wegmann, Yves Laumonnier, J Duhn, Gudrun Ulrich-Merzenich, Katherina Sewald, Matthias V. Kopp, Janette K. Burgess, Oliver Fuchs, Christine Happle, J M Bülow Sand, Markus Weckmann, Bianca Schaub, Klaus F. Rabe, Lars Lunding, E. von Mutius, I Koenig, S Rank Rønnow, Thomas Bahmer
Publikováno v:
05.03 - Allergy and immunology.
Introduction: COL4A3 degradation is significantly increased in severe, exacerbating type 2 asthmatics and correlates with increased chymase positive mast cells (mouse model of asthma). However, whether chymase is sufficient/necessary for COL4A3 degra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::207745bfad8607d1e4ee450ee77aa2e4
https://doi.org/10.1183/23120541.lsc-2021.16
https://doi.org/10.1183/23120541.lsc-2021.16
Autor:
Yves Laumonnier, J Duhn, Marnix R. Jonker, Jannie M.B. Sand, Klaus F. Rabe, Maarten van den Berge, Markus Weckmann, Bianca Schaub, Christine Happle, Anna-Maria Dittrich, Matthias V. Kopp, Lars Lunding, Michael Wegmann, Inke R. König, Janette K. Burgess, Thomas Bahmer, D.J. Leeming, E. von Mutius, Ulrich M. Zissler, Gesine Hansen, Oliver Fuchs, B. Oliver, Katherina Sewald, Olga Danov, Morten A. Karsdal, Sarah Rønnow
Publikováno v:
03.03 - Mechanisms of lung injury and repair.
Introduction: Remodeling of the airway wall is a hallmark feature of asthma. Under physiological conditions, a finely tuned balance maintains a functional state of the extracellular matrix. This balance is disrupted in asthma. COL4A3 is reduced 18-fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498c143b51e6af0814da838e678cfcee
https://doi.org/10.1183/23120541.lsc-2021.10
https://doi.org/10.1183/23120541.lsc-2021.10