Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Marnix H, Medema"'
Autor:
Barbara R. Terlouw, Friederike Biermann, Sophie P. J. M. Vromans, Elham Zamani, Eric J. N. Helfrich, Marnix H. Medema
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract Natural products are molecules that fulfil a range of important ecological functions. Many natural products have been exploited for pharmaceutical and agricultural applications. In contrast to many other specialised metabolites, the products
Externí odkaz:
https://doaj.org/article/05b9a26e73d14f05a536e4c5488a18c0
Autor:
Wanrong Luo, Min Zhao, Mohammed Dwidar, Yang Gao, Liyuan Xiang, Xueting Wu, Marnix H. Medema, Shu Xu, Xiaozhi Li, Hendrik Schäfer, Minhu Chen, Rui Feng, Yijun Zhu
Publikováno v:
Microbiome, Vol 12, Iss 1, Pp 1-20 (2024)
Abstract Background H2S imbalances in the intestinal tract trigger Crohn's disease (CD), a chronic inflammatory gastrointestinal disorder characterized by microbiota dysbiosis and barrier dysfunction. However, a comprehensive understanding of H2S gen
Externí odkaz:
https://doaj.org/article/42fb619f1b20450f946768897438587a
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-8 (2024)
Abstract Effective visualization of small molecules is paramount in conveying concepts and results in cheminformatics. Scalable vector graphics (SVG) are preferred for creating such visualizations, as SVGs can be easily altered in post-production and
Externí odkaz:
https://doaj.org/article/49db27d1f1e54435bef280295e73d468
Autor:
Guillermo Guerrero-Egido, Adrian Pintado, Kevin M. Bretscher, Luisa-Maria Arias-Giraldo, Joseph N. Paulson, Herman P. Spaink, Dennis Claessen, Cayo Ramos, Francisco M. Cazorla, Marnix H. Medema, Jos M. Raaijmakers, Víctor J. Carrión
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Bacteria have an extensive adaptive ability to live in close association with eukaryotic hosts, exhibiting detrimental, neutral or beneficial effects on host growth and health. However, the genes involved in niche adaptation are mostly unkno
Externí odkaz:
https://doaj.org/article/cf4ad56f13eb40bea088c5fd2ff9a163
Autor:
Floriane Odje, David Meijer, Elena von Coburg, Justin J. J. van der Hooft, Sebastian Dunst, Marnix H. Medema, Andrea Volkamer
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
The cell painting (CP) assay has emerged as a potent imaging-based high-throughput phenotypic profiling (HTPP) tool that provides comprehensive input data for in silico prediction of compound activities and potential hazards in drug discovery and tox
Externí odkaz:
https://doaj.org/article/db08b0896cf645dfbf1580b3e2b0f380
Autor:
Matthias van den Belt, Cameron Gilchrist, Thomas J. Booth, Yit-Heng Chooi, Marnix H. Medema, Mohammad Alanjary
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-8 (2023)
Abstract Background Co-localized sets of genes that encode specialized functions are common across microbial genomes and occur in genomes of larger eukaryotes as well. Important examples include Biosynthetic Gene Clusters (BGCs) that produce speciali
Externí odkaz:
https://doaj.org/article/ce3ee01c945f4592902421521f44c479
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-12 (2023)
Abstract Background It is well-known that the microbiome produces a myriad of specialised metabolites with diverse functions. To better characterise their structures and identify their producers in complex samples, integrative genome and metabolome m
Externí odkaz:
https://doaj.org/article/64adb32a491840738686867bbd496ca0
Autor:
Ben O. Oyserman, Stalin Sarango Flores, Thom Griffioen, Xinya Pan, Elmar van der Wijk, Lotte Pronk, Wouter Lokhorst, Azkia Nurfikari, Joseph N. Paulson, Mercedeh Movassagh, Nejc Stopnisek, Anne Kupczok, Viviane Cordovez, Víctor J. Carrión, Wilco Ligterink, Basten L. Snoek, Marnix H. Medema, Jos M. Raaijmakers
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Genetics factors involved in rhizosphere microbiomes assembly remain largely elusive. Here, the authors integrate microbiomics and quantitative plant genetics to reveal genetic loci associated with specific microbes and rhizobacterial traits underlyi
Externí odkaz:
https://doaj.org/article/499c7c7c3e5340bf83c23e2b7e9bf1f6
Publikováno v:
Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-17 (2022)
Abstract As efforts to computationally describe and simulate the biochemical world become more commonplace, computer programs that are capable of in silico chemistry play an increasingly important role in biochemical research. While such programs exi
Externí odkaz:
https://doaj.org/article/dbcaeb216882446096e7079775936517
Publikováno v:
Journal of Pure and Applied Microbiology, Vol 16, Iss 1, Pp 460-470 (2022)
Halophilic archaeon Halolamina pelagica CDK2, showcasing plant growth-promoting properties and endurance towards harsh environmental conditions (high salinity, heavy metals, high temperature and UV radiation) was sequenced earlier. Pan-genome of Halo
Externí odkaz:
https://doaj.org/article/23a0109187c0417f822f89bbef5fc5c2