Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Marnix Geukes"'
Autor:
Benjamin Weide, Claus Garbe, Graham Pawelec, Christian Blank, Jedd D. Wolchok, Peter Martus, Thomas K. Eigentler, Jessica C. Hassel, Dirk Schadendorf, Antje Sucker, Bastian Schilling, Michele Maio, Anna Maria Di Giacomo, Paolo A. Ascierto, Mariaelena Capone, Brigitte Dreno, Amir Khammari, Emanuela Romano, Phillip Wong, Michael A. Postow, Jianda Yuan, Marnix Geukes Foppen, Kilian Wistuba-Hamprecht, Alexander Martens
Calibration of combination models. Calibration was calculated after 12 and 24 months using the calibrate function in the rms package of R for combination model 1 (A) and combination model 2 (B). Bootstrapping (1000 repeats) was performed to obtain bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11677ba9095d79f11da3f21977bb5f3
https://doi.org/10.1158/1078-0432.22459688
https://doi.org/10.1158/1078-0432.22459688
Autor:
Benjamin Weide, Claus Garbe, Graham Pawelec, Christian Blank, Jedd D. Wolchok, Peter Martus, Thomas K. Eigentler, Jessica C. Hassel, Dirk Schadendorf, Antje Sucker, Bastian Schilling, Michele Maio, Anna Maria Di Giacomo, Paolo A. Ascierto, Mariaelena Capone, Brigitte Dreno, Amir Khammari, Emanuela Romano, Phillip Wong, Michael A. Postow, Jianda Yuan, Marnix Geukes Foppen, Kilian Wistuba-Hamprecht, Alexander Martens
Multivariate Models including only patients receiving 3 mg/kg ipilimumab. Lactate dehydrogenase (LDH), regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), hazard ratio (HR). * Relative lymphocyte count, absolute monocyte count, abso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f44d77b1581d9ffc02cb066001dd72a
https://doi.org/10.1158/1078-0432.22459673.v1
https://doi.org/10.1158/1078-0432.22459673.v1
Autor:
Benjamin Weide, Claus Garbe, Graham Pawelec, Christian Blank, Jedd D. Wolchok, Peter Martus, Thomas K. Eigentler, Jessica C. Hassel, Dirk Schadendorf, Antje Sucker, Bastian Schilling, Michele Maio, Anna Maria Di Giacomo, Paolo A. Ascierto, Mariaelena Capone, Brigitte Dreno, Amir Khammari, Emanuela Romano, Phillip Wong, Michael A. Postow, Jianda Yuan, Marnix Geukes Foppen, Kilian Wistuba-Hamprecht, Alexander Martens
Discriminatory ability of combination models. The concordance index (c-index, y-axis) was calculated for the combination of factors with independent impact according to Cox regression analysis (model 6.1) and 13 alternative combination models conside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dbce73ba4b68eaf99a7acfe21852d5f
https://doi.org/10.1158/1078-0432.22459691
https://doi.org/10.1158/1078-0432.22459691
Autor:
Benjamin Weide, Claus Garbe, Graham Pawelec, Christian Blank, Jedd D. Wolchok, Peter Martus, Thomas K. Eigentler, Jessica C. Hassel, Dirk Schadendorf, Antje Sucker, Bastian Schilling, Michele Maio, Anna Maria Di Giacomo, Paolo A. Ascierto, Mariaelena Capone, Brigitte Dreno, Amir Khammari, Emanuela Romano, Phillip Wong, Michael A. Postow, Jianda Yuan, Marnix Geukes Foppen, Kilian Wistuba-Hamprecht, Alexander Martens
Correlations between adverse events and overall survival, clinical response, or biomarker categories. Overall survival was not different between patients stratified according to the occurrence of adverse events (AEs) in general (A) or immune-related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0d1b2cc4a8a5f6df292e3fddda9115
https://doi.org/10.1158/1078-0432.22459685
https://doi.org/10.1158/1078-0432.22459685
Autor:
Benjamin Weide, Claus Garbe, Graham Pawelec, Christian Blank, Jedd D. Wolchok, Peter Martus, Thomas K. Eigentler, Jessica C. Hassel, Dirk Schadendorf, Antje Sucker, Bastian Schilling, Michele Maio, Anna Maria Di Giacomo, Paolo A. Ascierto, Mariaelena Capone, Brigitte Dreno, Amir Khammari, Emanuela Romano, Phillip Wong, Michael A. Postow, Jianda Yuan, Marnix Geukes Foppen, Kilian Wistuba-Hamprecht, Alexander Martens
Spectrum of factors, cut-offs, and differences in overall survival according to biomarkers in the identification and the confirmation cohort. Absolute (Abs.), Relative (Rel.), Lactate dehydrogenase (LDH), regulatory T cells (Tregs), myeloid-derived s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d6dcee2407ee28cf986f4d5540e0b7
https://doi.org/10.1158/1078-0432.22459676.v1
https://doi.org/10.1158/1078-0432.22459676.v1
Autor:
Benjamin Weide, Claus Garbe, Graham Pawelec, Christian Blank, Jedd D. Wolchok, Peter Martus, Thomas K. Eigentler, Jessica C. Hassel, Dirk Schadendorf, Antje Sucker, Bastian Schilling, Michele Maio, Anna Maria Di Giacomo, Paolo A. Ascierto, Mariaelena Capone, Brigitte Dreno, Amir Khammari, Emanuela Romano, Phillip Wong, Michael A. Postow, Jianda Yuan, Marnix Geukes Foppen, Kilian Wistuba-Hamprecht, Alexander Martens
Panels of antibodies used for flow cytometry. * Cells were fixed and permeabilized with FoxP3 buffer (BD). Only frequencies of CD14+ cells from MDSC panel 1 and frequencies of CD4+, CD8+ T cells, as well as their ratio, were included from Treg panel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1506ffc8ead31b94ebc645908f6e711b
https://doi.org/10.1158/1078-0432.22459679.v1
https://doi.org/10.1158/1078-0432.22459679.v1
Autor:
Benjamin Weide, Claus Garbe, Graham Pawelec, Christian Blank, Jedd D. Wolchok, Peter Martus, Thomas K. Eigentler, Jessica C. Hassel, Dirk Schadendorf, Antje Sucker, Bastian Schilling, Michele Maio, Anna Maria Di Giacomo, Paolo A. Ascierto, Mariaelena Capone, Brigitte Dreno, Amir Khammari, Emanuela Romano, Phillip Wong, Michael A. Postow, Jianda Yuan, Marnix Geukes Foppen, Kilian Wistuba-Hamprecht, Alexander Martens
Purpose: To identify baseline peripheral blood biomarkers associated with clinical outcome following ipilimumab treatment in advanced melanoma patients.Experimental Design: Frequencies of myeloid-derived suppressor cells (MDSC) and regulatory T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044adbcffbaab232fd51ecd55d6b21b4
https://doi.org/10.1158/1078-0432.c.6524282
https://doi.org/10.1158/1078-0432.c.6524282
Autor:
Benjamin Weide, Claus Garbe, Graham Pawelec, Christian Blank, Jedd D. Wolchok, Peter Martus, Thomas K. Eigentler, Jessica C. Hassel, Dirk Schadendorf, Antje Sucker, Bastian Schilling, Michele Maio, Anna Maria Di Giacomo, Paolo A. Ascierto, Mariaelena Capone, Brigitte Dreno, Amir Khammari, Emanuela Romano, Phillip Wong, Michael A. Postow, Jianda Yuan, Marnix Geukes Foppen, Kilian Wistuba-Hamprecht, Alexander Martens
Detailed gating strategy for quantification of subsets of monocytes and myeloid-derived suppressor cells (MDSCs), T cells and regulatory T cells (Tregs). Total cells were selected by gating on Time vs. SSC-A. Duplicates were removed via progressive g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d02163c426927917a668caaf646883
https://doi.org/10.1158/1078-0432.22459694.v1
https://doi.org/10.1158/1078-0432.22459694.v1
Autor:
Benjamin Weide, Claus Garbe, Graham Pawelec, Christian Blank, Jedd D. Wolchok, Peter Martus, Thomas K. Eigentler, Jessica C. Hassel, Dirk Schadendorf, Antje Sucker, Bastian Schilling, Michele Maio, Anna Maria Di Giacomo, Paolo A. Ascierto, Mariaelena Capone, Brigitte Dreno, Amir Khammari, Emanuela Romano, Phillip Wong, Michael A. Postow, Jianda Yuan, Marnix Geukes Foppen, Kilian Wistuba-Hamprecht, Alexander Martens
Overall survival and distribution after first dose of ipilimumab according to subsequent treatments. Of 209 patients, 71 received at least one additional systemic line of treatment after ipilimumab. 137 individuals did not receive further therapy and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::215ab847c31dc90431e21ec7fee36f0f
https://doi.org/10.1158/1078-0432.22459682
https://doi.org/10.1158/1078-0432.22459682
Autor:
Christian U. Blank, Hans van Thienen, Pia Kvistborg, Marnix Geukes, Joost H. van den Berg, Ton N. Schumacher, John B. A. G. Haanen, Maaike van Zon, Noor A. M. Bakker
Publikováno v:
Molecular Cancer Therapeutics. 14:PL01-03
Infusion of tumor-infiltrating T-lymphocytes was developed as treatment for metastatic melanoma by Dr. S. Rosenberg (Surgery Branch, NIH, Bethesda, MD, USA) in the late 90's of the past century. This therapy was based on the finding that melanomas of