Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Marnie A. Higgins"'
Publikováno v:
BioTechniques, Vol 45, Iss 3, Pp 283-292 (2008)
Genome-scale gene expression technologies are increasingly being applied for biological research as a whole and toxicological screening in particular. In order to monitor data quality and process drift, we adopted the use of two rat-tissue mixtures (
Externí odkaz:
https://doaj.org/article/3308a62c30d3460e9801bfc15407fadd
Autor:
Timothy P. Ryan, Joanne S. Ingwall, Najia Jin, Robert M. Gill, Laura J. Bloem, Matthias Spindler, Marnie A. Higgins, Weiqun Shen
Publikováno v:
Journal of Molecular and Cellular Cardiology. 39:537-544
Decreases in total creatine kinase (CK) activity and creatine [Cr] combine to limit the capacity of the failing heart to rapidly re-synthesize ATP (energy reserve). If the loss in energy reserve could be reversed, cardiac contractile reserve may be i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3bb1f2d8b00191b3ea7c9156bb838b
https://doi.org/10.1016/j.yjmcc.2005.05.003
https://doi.org/10.1016/j.yjmcc.2005.05.003
Autor:
David O. Calligaro, Marnie A. Higgins, Linda M. Schirtzinger, Timothy P. Ryan, Hong Gao, Elizabeth Galbreath, George H. Searfoss, Patrick C. May, Brian R. Berridge, William H. Jordan
Publikováno v:
Journal of Biological Chemistry. 278:46107-46116
Functional gamma-secretase inhibitors (FGSIs) can block the cleavage of several transmembrane proteins including amyloid precursor protein (APP), and the cell fate regulator Notch-1. FGSIs, by inhibiting APP processing, block the generation of amyloi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7791b07ee5e6c1da0cd8fb889cf4ff
https://doi.org/10.1074/jbc.m307757200
https://doi.org/10.1074/jbc.m307757200
Autor:
Marnie A. Higgins, B. J. Mills, Thomas K. Baker, B. R. Berridge, Hong Gao, Timothy P. Ryan, George H. Searfoss, A. E. Schultze
Publikováno v:
Toxicological Sciences. 74:470-484
The safety of pharmaceuticals is typically assessed in the dog and rat prior to investigation in humans. As a result, a greater understanding of adverse effects in these preclinical testing species would improve safety assessment. Despite this need,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b99e26ed9f80e3c509c690d4f4e1024
https://doi.org/10.1093/toxsci/kfg142
https://doi.org/10.1093/toxsci/kfg142
Autor:
Marnie A. Higgins, Heather J. Barker, Ann Maslen, James Gilmore, Kim Boudreau, Gordon M. Kirby, Laura Romero
Publikováno v:
Drug Metabolism and Disposition. 30:1186-1193
The influence of pro-inflammatory cytokines on alpha class glutathione S-transferase A1 and A2 (GSTA1/A2) expression was examined in human colonic epithelial cells (Caco-2) in culture. Dose-dependent reductions in GSTA1/A2 mRNA, protein, and activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90daa34864c8aab812c5979bafbe316
https://doi.org/10.1124/dmd.30.11.1186
https://doi.org/10.1124/dmd.30.11.1186
Autor:
Laura Healy, Marque D. Todd, Cynthia A. Afshari, James Meyer, Marnie A. Higgins, Hisham K. Hamadeh, Annie M. Kwok
Publikováno v:
Chemical research in toxicology. 23(6)
The key to the discovery of new pharmaceuticals is to develop molecules that interact with the intended target and minimize interaction with unintended molecular targets, therefore minimizing toxicity. This is aided by the use of various in vitro sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c53ce1e640e9a0700804d790cff6be4
https://pubmed.ncbi.nlm.nih.gov/20521778
https://pubmed.ncbi.nlm.nih.gov/20521778
Autor:
Brian R. Berridge, Timothy P. Ryan, George E. Lees, Melissa L. Cox, Keith E. Murphy, Clifford E. Kashtan, Marnie A. Higgins, Kimberly A. Greer
Publikováno v:
Mammalian genome : official journal of the International Mammalian Genome Society. 17(9)
Chronic kidney disease (CKD) often culminates in renal failure as a consequence of progressive interstitial fibrosis and is an important cause of illness and death in dogs. Identification of disease biomarkers and gene expression changes will yield v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::273ecefc3279ed1838fbcb3e8e550f48
https://pubmed.ncbi.nlm.nih.gov/16964446
https://pubmed.ncbi.nlm.nih.gov/16964446
Publikováno v:
An Introduction to Toxicogenomics ISBN: 9780429211089
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6368f9a70dbec9a0c14371452f751692
https://doi.org/10.1201/9780203504819-7
https://doi.org/10.1201/9780203504819-7
