Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Marna C. W. Pippel"'
Autor:
Christopher M. Mapes, Shirin Shinde, Kelly J. McClure, Laurent Gomez, J. Guy Breitenbucher, Todd K. Jones, Clark A. Sehon, Neelakandha S. Mani, Marna C. W. Pippel, Xiaohu Deng, Chennagiri R. Pandit
Publikováno v:
The Journal of Organic Chemistry. 75:7950-7953
We describe a practical and scalable route to compound (Z)-1, a selective CCK1 receptor antagonist. Notable features of this concise route are (1) a regioselective construction of the pyrazole core through the reaction of an aryl hydrazine and an ela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13646b1c64bcf2dff772564571602c82
https://doi.org/10.1021/jo1017684
https://doi.org/10.1021/jo1017684
Publikováno v:
Organic Process Research & Development. 10:1287-1291
4-Halo-2-nitrobenzoic acids are synthesized by oxidation of 4-halo-2-nitrotoluene with tetrabutylammonium permanganate (TBAP) in pyridine in multigram quantities. A significant induction period is observed at room temperature, and the vigorous exothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b93a4fad855ff12f20d4f814da30db58
https://doi.org/10.1021/op060102v
https://doi.org/10.1021/op060102v
Autor:
Nigel P. Shankley, Lina Li, Marna C. W. Pippel, Brett D. Allison, Clodagh Prendergast, Xiaodong Wu, Magda F. Morton, Michael H. Rabinowitz, Victor K. Phuong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6373-6375
A series of CCK2R-selective anthranilic amides is shown to derive CCK1R affinity via selective substitution of the amide side chain. Thus, extending the length of the original benzamide side chain by a single methylene unit imparts CCK1R affinity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03db009be0df32eedf90a2e2f6669c7a
https://doi.org/10.1016/j.bmcl.2009.09.064
https://doi.org/10.1016/j.bmcl.2009.09.064
Autor:
Victor K. Phuong, Michael H. Rabinowitz, Hariharan Venkatesan, Wen Yan, Kristen Boyce, Xiaodong Wu, Nigel P. Shankley, Magda F. Morton, Marna C. W. Pippel, Clodagh Prendergast, Guy Lagaud, Lina Li, Terrance D. Barrett
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(22)
In the previous article we demonstrated how certain CCK2R-selective anthranilic amides could be structurally modified to afford high-affinity, selective CCK1R activity. We now describe our efforts at modulating and optimizing the CCK1R and CCK2R affi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf2b3de94f887f87012ca87ff79bc5e
https://pubmed.ncbi.nlm.nih.gov/19815410
https://pubmed.ncbi.nlm.nih.gov/19815410
Autor:
Guy Lagaud, Xiaodong Wu, Xiaohu Deng, Michael H. Rabinowitz, Marna C. W. Pippel, Nigel P. Shankley, Mark D. Rosen, Michael D. Hack, Terry Barrett, Clodagh Prendergast, Craig R. Woods, Laura C. Mcatee, Magda F. Morton, Kenway Hoey, Victor K. Phuong, Lina Li, Hariharan Venkatesan, Michele C. Rizzolio, Jamie M. Freedman, Brett D. Allison, Christopher King
Publikováno v:
Journal of medicinal chemistry. 49(21)
A high throughput screening approach to the identification of selective cholecystokinin-2 receptor (CCK-2R) ligands resulted in the discovery of a novel series of antagonists, represented by 1-[2-[(2,1,3-benzothiadiazol-4-ylsulfonyl)amino]-5-chlorobe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b1a1c9e887440569b7beb4131d97ec
https://pubmed.ncbi.nlm.nih.gov/17034143
https://pubmed.ncbi.nlm.nih.gov/17034143