Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Marlys Hammond"'
Autor:
Donald P. McDonnell, John D. Norris, Dmitri Kazmin, Scott K. Thompson, Jaclyn R. Patterson, Marlys Hammond, Walter Trizna, Nicholas J. Laping, Jeffrey D. Bray, Christine G. Schnackenberg, Daniel E. Frigo, Andrea B. Sherk
Androgens, through their actions on the androgen receptor (AR), are required for the development of the prostate and contribute to the pathologic growth dysregulation observed in prostate cancers. Consequently, androgen ablation has become an essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e83eb3282c67e787f8942ba5a7c35a
https://doi.org/10.1158/0008-5472.c.6498402
https://doi.org/10.1158/0008-5472.c.6498402
Autor:
Donald P. McDonnell, John D. Norris, Dmitri Kazmin, Scott K. Thompson, Jaclyn R. Patterson, Marlys Hammond, Walter Trizna, Nicholas J. Laping, Jeffrey D. Bray, Christine G. Schnackenberg, Daniel E. Frigo, Andrea B. Sherk
Supplementary Data from Development of a Small-Molecule Serum- and Glucocorticoid-Regulated Kinase-1 Antagonist and Its Evaluation as a Prostate Cancer Therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd34ad071b42869122db0e920ae8004b
https://doi.org/10.1158/0008-5472.22377012.v1
https://doi.org/10.1158/0008-5472.22377012.v1
Autor:
Eidam Hilary Schenck, Theresa J. Roethke, Linda S. Barton, Fox Ryan Michael, Steve Zhao, Kevin S. Thorneloe, David J. Behm, Guosen Ye, Patrick Stoy, Mui Cheung, Tram H. Hoang, Dennis A. Holt, Krista B. Goodman, Brian G. Lawhorn, Marlys Hammond, Mark A. Hilfiker, Carl Brooks, Jaclyn R. Patterson
Publikováno v:
ACS Med Chem Lett
[Image: see text] GSK2798745, a clinical candidate, was identified as an inhibitor of the transient receptor potential vanilloid 4 (TRPV4) ion channel for the treatment of pulmonary edema associated with congestive heart failure. We discuss the lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9fa0019b6d3c13ef62367e4364c46c
https://doi.org/10.1021/acsmedchemlett.9b00274
https://doi.org/10.1021/acsmedchemlett.9b00274
Autor:
Theresa J. Roethke, Guosen Ye, Hong Zhang, Robert T. Gampe, Robert A. Reid, Brian G. Lawhorn, Tram H. Hoang, Dennis A. Holt, Bob Willette, Marlys Hammond, David G. Washburn, Sharada Manns, Mark A. Hilfiker, Steve Zhao, Fox Ryan Michael, Joanne Prendergast, Eidam Hilary Schenck, Amy M. Quinn, Lara S. Kallander, Sarah E. Dowdell, Alan R. Rendina, Elsie Diaz, Xuan Hong
Publikováno v:
ACS Medicinal Chemistry Letters. 9:736-740
[Image: see text] Bone Morphogenetic Protein 1 (BMP1) inhibition is a potential method for treating fibrosis because BMP1, a member of the zinc metalloprotease family, is required to convert pro-collagen to collagen. A novel class of reverse hydroxam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d24636bada9e4802bb362a0091a96d4
https://doi.org/10.1021/acsmedchemlett.8b00173
https://doi.org/10.1021/acsmedchemlett.8b00173
Autor:
Dennis A. Holt, Gatto Gregory J, Joanne Philp, Sharon Sweitzer, Marlys Hammond, Guofeng Zhang, Mui Cheung, Rachel D. Totoritis, Lisa M. Shewchuk, Liping Wang, Huizhen Zhao, Benjamin Schwartz, Joshua E. Cottom, Harvey E. Fries, Brian G. Lawhorn, Hu Li, Alan P. Graves, Hongwei Qi, Yongdong Zhao, Lara S. Kallander, Christopher Louer
Publikováno v:
Journal of Medicinal Chemistry. 58:7431-7448
A series of cardiac troponin I-interacting kinase (TNNI3K) inhibitors arising from 3-((9H-purin-6-yl)amino)-N-methyl-benzenesulfonamide (1) is disclosed along with fundamental structure-function relationships that delineate the role of each element o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b14c60502bbe430a3543db76327813
https://doi.org/10.1021/acs.jmedchem.5b00931
https://doi.org/10.1021/acs.jmedchem.5b00931
Autor:
Marlys Hammond, David A. Griffith, Philip A. Carpino, Steven R. Schneider, Robert L. Dow, Paul DaSilva-Jardine, John R. Hadcock, Philip A. Iredale, Dennis O. Scott, Ernest S. Paight
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5351-5354
A new series of CB(1) receptor antagonists incorporating an imidazole-based isosteric replacement for the hydrazide moiety of rimonabant (SR141716) is disclosed. Members of this imidazole series possess potent/selective binding to the rCB(1) receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4fb2f93da026a0faa073ffb8e71095a
https://doi.org/10.1016/j.bmcl.2009.07.130
https://doi.org/10.1016/j.bmcl.2009.07.130
Autor:
Rakesh Nagilla, Sharada Manns, Eugene L. Stewart, Marlys Hammond, Tram H. Hoang, Scott K. Thompson, Walter Trizna, Chaya Duraiswami, Eugene T. Grygielko, Thuy B. Tran, James S. Frazee, Kevin P. Madauss, Johnson Latisha C, Shawn P. Williams, Lindsay E. Glace, David G. Washburn, Jeffrey D. Bray
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4664-4668
We have designed and synthesized a novel series of pyrrolidinones as progesterone receptor partial agonists. Compounds from this series had improved AR selectivity, rat pharmacokinetic properties, and in vivo potency compared to the lead compound. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e117925c53a26178fac52da1fa94885
https://doi.org/10.1016/j.bmcl.2009.06.081
https://doi.org/10.1016/j.bmcl.2009.06.081
Autor:
Terrell A. Patterson, James V. Cassella, Paul DaSilva-Jardine, R W Stevenson, Li She, Diane M. Hargrove, Kelly A. Martin, Richard L. Elliott, Robert M. Oliver, Marlys Hammond, Christine M. Mack, J. Cory Kalvass, Tristan S. Maurer, Morgan Bradley P
Publikováno v:
Journal of Medicinal Chemistry. 46:670-673
To investigate the anorectic potential of NPY5 receptor antagonists, we have profiled the in vitro and in vivo properties of 3-[2-[6-(2-tert-butoxyethoxy)pyridin-3-yl]-1H-imidazol-4-yl]benzonitrile hydrochloride salt (1). This compound was found to h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d1e1b4a42bca5bdaeb1525ab350af7
https://doi.org/10.1021/jm025584p
https://doi.org/10.1021/jm025584p
Autor:
Ralf Glatthar, Philip M. Harrington, Scott E. Schaus, Elaine Y. Kuo, Jia-Ning Xiang, Jun Liang, Andrew G. Myers, Yusheng Wu, Marlys Hammond
Publikováno v:
Journal of the American Chemical Society. 124:5380-5401
A convergent, enantioselective synthetic route to the natural product neocarzinostatin chromophore (1) is described. Synthesis of the chromophore aglycon (2) was targeted initially. Chemistry previously developed for the synthesis of a neocarzinostat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2939c1449c8a7b46670fbb47c048a723
https://doi.org/10.1021/ja012487x
https://doi.org/10.1021/ja012487x
Publikováno v:
Journal of the American Chemical Society. 119:2965-2972
Through a comparative analysis of the reactivity and DNA cleaving activity of neocarzinostatin (NCS) chromophore (1) and the corresponding aglycon (2), we show that the carbohydrate residue (aminoglycoside) of 1 both accelerates the rate and improves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b274ed33ba6f877c44f1c6eed7ae2d99
https://doi.org/10.1021/ja9641719
https://doi.org/10.1021/ja9641719