Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Marly I. Roche"'
Autor:
Bernard Khor, John D Gagnon, Gautam Goel, Marly I Roche, Kara L Conway, Khoa Tran, Leslie N Aldrich, Thomas B Sundberg, Alison M Paterson, Scott Mordecai, David Dombkowski, Melanie Schirmer, Pauline H Tan, Atul K Bhan, Rahul Roychoudhuri, Nicholas P Restifo, John J O'Shea, Benjamin D Medoff, Alykhan F Shamji, Stuart L Schreiber, Arlene H Sharpe, Stanley Y Shaw, Ramnik J Xavier
Publikováno v:
eLife, Vol 4 (2015)
The balance between Th17 and T regulatory (Treg) cells critically modulates immune homeostasis, with an inadequate Treg response contributing to inflammatory disease. Using an unbiased chemical biology approach, we identified a novel role for the dua
Externí odkaz:
https://doaj.org/article/8d529be262854d4f87b10c044565271a
Autor:
Zhaohua Lu, Michael J Rynkiewicz, Guillermo Madico, Sheng Li, Chiou-Ying Yang, Hillary M Perkins, Seshi R Sompuram, Vani Kodela, Tong Liu, Timothy Morris, Daphne Wang, Marly I Roche, Barbara A Seaton, Jacqueline Sharon
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99847 (2014)
The chaperonin protein GroEL, also known as heat shock protein 60 (Hsp60), is a prominent antigen in the human and mouse antibody response to the facultative intracellular bacterium Francisella tularensis (Ft), the causative agent of tularemia. In ad
Externí odkaz:
https://doaj.org/article/7dc9e291566044069dd836840fb7f1cd
Autor:
Tina Zimmermann, Steven Bench, Andrea Romagnani, Klaus P. Hoeflich, Carsten Wolter, Michael Sheets, Kerrie Faia, Kerry-Ann Bright, Timothy LaBranche, Marion Dorsch, Alberto Toso, Gordon Heidkamp, James R. Bischoff, Alison Ribeiro, Joshua Close, Marina Bacac, Felix Scheuplein, Nisha Perez, Caitlin Utt, Emanuele Perola, Jan Eckmann, Kristina Fetalvero, Stefan Gross, Qiongfang Cao, Debora Paduraru, Grace O. Silva, Chaoyang Ye, Marly I. Roche, Luke Green, Erin O’Hearn, Tary Traore, Weifan Weng, Jason D. Brubaker, Joseph Kim, Michael Burke, Sylvia Herter, Chandra Miduturu, Erik Gerson, Tim Guzi, Rich Woessner
Publikováno v:
Cancer Research. 81:1717-1717
Hematopoietic progenitor kinase 1 (HPK1, MAP4K1) is a serine/threonine kinase that has been demonstrated to have suppressive effects across a range of immune cells, including T cells and dendritic cells. Loss of MAP4K1 kinase activity is sufficient t
Autor:
Guillermo Madico, Michael J. Rynkiewicz, Zhaohua Lu, Chiou-Ying Yang, Marly I. Roche, Jacqueline Sharon, Barbara A. Seaton, Hillary M. Perkins
Publikováno v:
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 33:235-245
The O-antigen (OAg) of the Gram-negative bacterium Francisella tularensis (Ft), which is both a capsular polysaccharide and a component of lipopolysaccharide, is comprised of tetrasaccharide repeats and induces antibodies mainly against repeating int
Autor:
Jacqueline Sharon, Julia H. Hui, Catherine E. Costello, Guillermo Madico, Zhaohua Lu, Qi Wang, Marly I. Roche, Joseph Zaia, Hillary M. Perkins
Publikováno v:
Immunology. 136:352-360
Antibodies to the lipopolysaccharide (LPS) of Francisella tularensis have been shown to be protective against respiratory tularaemia in mouse models, and we have previously described mouse monoclonal antibodies (mAbs) to non-overlapping terminal and
Autor:
Thomas Ludwig, James J. Moon, Ravisankar A. Ramadas, Marly I. Roche, Ramnik J. Xavier, Benjamin D. Medoff
Publikováno v:
The Journal of Immunology. 187:6197-6207
CARMA1 is a lymphocyte-specific scaffold protein necessary for T cell activation. Deletion of CARMA1 prevents the development of allergic airway inflammation in a mouse model of asthma due to a defect in naive T cell activation. However, it is unknow
Publikováno v:
Hybridoma. 30:19-28
The lipopolysaccharide (LPS) of Francisella tularensis (Ft), the Gram negative bacterium that causes tularemia, has been shown to be a main protective antigen in mice and humans; we have previously demonstrated that murine anti-Ft LPS IgG2a monoclona
Autor:
Marly I. Roche, Brent R. Williams, Meredith A. Liebman, Jacqueline Sharon, Jae Kim, Steven C. Pageau
Publikováno v:
Immunology Letters. 114:16-22
Athymic nude mice bearing subcutaneous tumor xenografts of the human anti-colorectal cancer cell line SW480 were used as a preclinical model to explore anti-tumor immunotherapies. Intratumor or systemic treatment of the mice with murine anti-SW480 se
Autor:
Philip L. Felgner, Sunita Gulati, Berkay Unal, Zhaohua Lu, Marly I. Roche, Julia H. Hui, Guillermo Madico, Jacqueline Sharon
Publikováno v:
Immunology Letters. 112:92-103
Tularemia is caused by the Gram-negative facultative intracellular bacterium Francisella tularensis, which has been classified as a Category A Select Agent – a likely bioweapon. The high virulence of F. tularensis and the threat of engineered antib
Autor:
Marly I. Roche, Melanie Schirmer, Gautam Goel, Atul K. Bhan, Alykhan F. Shamji, John J. O'Shea, David Dombkowski, Thomas B. Sundberg, Stuart L. Schreiber, John D. Gagnon, Bernard Khor, Alison M. Paterson, Arlene H. Sharpe, Benjamin D. Medoff, Khoa D. Tran, Scott Mordecai, Kara L. Conway, Nicholas P. Restifo, Ramnik J. Xavier, Stanley Y. Shaw, Leslie N Aldrich, Rahul Roychoudhuri, Pauline H. Tan
Publikováno v:
eLife, Vol 4 (2015)
eLife
eLife
The balance between Th17 and T regulatory (Treg) cells critically modulates immune homeostasis, with an inadequate Treg response contributing to inflammatory disease. Using an unbiased chemical biology approach, we identified a novel role for the dua