Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Marlon D. Cowart"'
Autor:
Dominique Lambin, Katja Conrath, Tom De Munck, Ann De Blieck, Hans Kelgtermans, Steven Emiel Van Der Plas, Marlon D. Cowart, Christel Jeanne Marie Menet, Sebastien Dropsit, Caroline Joannesse, Oscar Mammoliti, Sebastien Laurent Xavier Martina, Maarten Gees, Giovanni Tricarico, Martin James Inglis Andrews, Anne-Sophie Wesse
Publikováno v:
Journal of Medicinal Chemistry. 64:343-353
Cystic fibrosis (CF) is a life-threatening recessive genetic disease caused by mutations in the gene encoding for the cystic fibrosis transmembrane conductance regulator (CFTR). With the discovery of Ivacaftor and Lumacaftor, it has been shown that a
Autor:
Nigel P. Shankley, Hiroyuki Fukui, Steve Liu, C. Robin Ganellin, Pertti Panula, Robin L. Thurmond, Roland Seifert, Stephen J. Hill, Jean-Charles Schwartz, Roberto Levi, Rob Leurs, Henk Timmerman, J. Michael Young, Ralf Gutzmer, Holger Stark, Paul L. Chazot, Rebecca Hills, Helmut L. Haas, Marlon D. Cowart, Walter Schunack
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
Histamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Histamine Receptors [80, 173]) are activated by the endogenous ligand histamine. Marked species differences exist between histamine receptor orthologues [80]. The human and
Autor:
Steven Emiel Van Der Plas, Ann De Blieck, Dominique Lambin, Giovanni Tricarico, Martin James Inglis Andrews, Anne-Sophie Wesse, Marlon D. Cowart, Katja Conrath, Tom De Munck, Maarten Gees, Christel Jeanne Marie Menet, Hans Kelgtermans, Oscar Mammoliti, Caroline Joannesse, Sebastien Laurent Xavier Martina, Sebastien Dropsit
Publikováno v:
Journal of Medicinal Chemistry. 64:13933-13933
Autor:
Henk Timmerman, J. Michael Young, Ralf Gutzmer, Nigel P. Shankley, Jean-Charles Schwartz, Holger Stark, Rebecca Hills, Robin L. Thurmond, Roberto Levi, Helmut L. Haas, Hiroyuki Fukui, Walter Schunack, Steve Liu, Rob Leurs, Roland Seifert, Paul L. Chazot, C. Robin Ganellin, Stephen J. Hill, Pertti Panula, Marlon D. Cowart
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2019
Histamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Histamine Receptors [75, 163]) are activated by the endogenous ligand histamine. Marked species differences exist between histamine receptor orthologues [75]. The human and
Autor:
Philip R. Kym, Arthur Gomtsyan, Gregory A. Gfesser, Bin Li, Regina M. Reilly, Bruce Clapham, Jerome F. Daanen, Rodger F. Henry, Torben R. Neelands, Pamela S. Puttfarcken, Susan M. Huang, Robert G. Schmidt, Robert J. Altenbach, S.K. Joshi, Huaqing Liu, Marlon D. Cowart, David N. Whittern, Phil B. Cox, Jill-Desiree Brederson, Michael J. Dart, Anurupa Shrestha, Donna Gauvin, Michael E. Kort, Erol K. Bayburt, Ping Song, Steve McGaraughty, Connie R. Faltynek, Heath A. McDonald, Patricia N. Banfor, Diana Schmidt, Eric A. Voight, Mohamad Shebley, Jason A. Segreti
Publikováno v:
Journal of Medicinal Chemistry. 59:4926-4947
Transient receptor potential vanilloid 3 (TRPV3) is a Ca(2+)- and Na(+)-permeable channel with a unique expression pattern. TRPV3 is found in both neuronal and non-neuronal tissues, including dorsal root ganglia, spinal cord, and keratinocytes. Recen
Autor:
Jorge D. Brioni, Tracy L. Carr, Gin C. Hsieh, Madhavi Pai, Lawrence A. Black, Tiffany Runyan Garrison, Cenchen Zhan, Marlon D. Cowart, Erica Gomez, Gilbert Diaz, Arlene M. Manelli, Marina I. Strakhova, Anthony Lee, Jill M. Wetter
Publikováno v:
European Journal of Pharmacology. 684:87-94
Histamine H(3) receptor antagonists have been widely reported to improve performance in preclinical models of cognition, but more recently efficacy in pain models has also been described. Here, A-960656 ((R)-2-(2-(3-(piperidin-1-yl)pyrrolidin-1-yl)be
Autor:
Tim A. Esbenshade, Jorge D. Brioni, Marlon D. Cowart, Tiffany Runyan Garrison, Scott R. Bitner
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 336:38-46
H(3) antagonists increase the release of brain histamine, acetylcholine, noradrenaline, and dopamine, neurotransmitters that are known to modulate cognitive processes. The ability to release brain histamine supports the effect on attention and vigila
Autor:
Arthur A. Hancock, Jill M. Wetter, Kennan C. Marsh, Prisca Honore, Gin C. Hsieh, Anita K. Salyers, Prasant Chandran, Timothy A. Esbenshade, Marlon D. Cowart, Joe Mikusa, Jorge D. Brioni, Erica J. Wensink, Madhavi Pai, Thomas R. Miller, Scott J. Baker, Chang Z. Zhu, David G. Witte
Publikováno v:
Pharmacology Biochemistry and Behavior. 95:41-50
The histamine H(4) receptor (H(4)R) is expressed primarily on cells involved in inflammation and immune responses. To determine the potential role of H(4)R in pain transmission, the effects of JNJ7777120, a potent and selective H(4) antagonist, were
Autor:
Kennan C. Marsh, Marlon D. Cowart, Jorge D. Brioni, Ivan Milicic, Timothy A. Esbenshade, J Bauch, J Du, Thomas R. Miller, Kaitlin E. Browman, Bruce W. Surber
Publikováno v:
British Journal of Pharmacology. 157:139-149
Background and purpose: The histamine H3 receptor antagonist radioligand [3H]-A-349821 was characterized as a radiotracer for assessing in vivo receptor occupancy by H3 receptor antagonists that affect behaviour. This model was established as an alte
Autor:
Timothy A. Esbenshade, Jorge D. Brioni, Kaitlin E. Browman, M. I. Strakhova, Marlon D. Cowart, R. S. Bitner
Publikováno v:
British Journal of Pharmacology. 154:1166-1181
The histamine H3 receptor, first described in 1983 as a histamine autoreceptor and later shown to also function as a heteroreceptor that regulates the release of other neurotransmitters, has been the focus of research by numerous laboratories as it r