Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Marlon Cowart"'
Autor:
Gert de Wilde, Maarten Gees, Sara Musch, Katleen Verdonck, Mia Jans, Anne-Sophie Wesse, Ashvani K. Singh, Tzyh-Chang Hwang, Thierry Christophe, Mathieu Pizzonero, Steven Van der Plas, Nicolas Desroy, Marlon Cowart, Pieter Stouten, Luc Nelles, Katja Conrath
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The deletion of phenylalanine at position 508 (F508del) in cystic fibrosis transmembrane conductance regulator (CFTR) causes a severe defect in folding and trafficking of the chloride channel resulting in its absence at the plasma membrane of epithel
Externí odkaz:
https://doaj.org/article/8d68380c55104f5f99c3962f9d0c136b
Autor:
J. Michael Young, Henk Timmerman, Robin Thurmond, Holger Stark, Nigel P. Shankley, Roland Seifert, Jean-Charles Schwartz, Walter Schunack, Pertti Panula, Steve Liu, Roberto Levi, Rob Leurs, Rebecca Hills, Stephen J. Hill, Helmut L. Haas, Ralf Gutzmer, C. Robin Ganellin, Hiroyuki Fukui, Marlon Cowart, Paul Chazot
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Histamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Histamine Receptors [80, 174]) are activated by the endogenous ligand histamine. Marked species differences exist between histamine receptor orthologues [80]. The human and
Autor:
Anne Sophie Wesse, Nicolas Desroy, Mathieu Rafaël Pizzonero, Mia Jans, Steven Emiel Van Der Plas, Katleen Verdonck, Katja Conrath, Tzyh Chang Hwang, Ashvani K. Singh, Gert Jules Hector De Wilde, Thierry Christophe, Pieter F. W. Stouten, Maarten Gees, Luc Nelles, Sara Musch, Marlon Cowart
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Frontiers in Pharmacology
Frontiers in Pharmacology
The deletion of phenylalanine at position 508 (F508del) in cystic fibrosis transmembrane conductance regulator (CFTR) causes a severe defect in folding and trafficking of the chloride channel resulting in its absence at the plasma membrane of epithel
Publikováno v:
Tetrahedron. 62:4584-4589
An efficient and convergent process for the preparation of a potent and selective H 3 receptor antagonist, ABT-239, 1A was accomplished with an overall yield of 64%. The key step in the synthesis is a Sonogashira coupling/cyclization reaction of 1-bu
Autor:
Ashok K. Gupta, Yu-Ming Pu, Ashok V. Bhatia, Daniel J. Plata, Marlon Cowart, Timothy A. Grieme, Yi-Yin Ku
Publikováno v:
Organic Process Research & Development. 9:45-50
A facile and scaleable synthesis of a potent and selective histamine H3 receptor antagonist, ABT-239 (1), was developed starting from commercially available 4‘-hydroxy-biphenyl-4-carbonitrile (2). The synthesis comprised four chemical steps and a s
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 34:67-71
A convenient small scale chemical synthesis of double labeled folic acid with 13C at positions C-7 and C-9 is reported. [1,3-13C2] acetone was converted into folic acid in two steps, with [1, 1, 3]-trichloroacetone as the labeled intermediate.
Autor:
Marlon, Cowart, Gin, Hsieh, Lawrence A, Black, Cenchen, Zhan, Erica J, Gomez, Madhavi, Pai, Marina, Strakhova, Arlene, Manelli, Tracy, Carr, Jill, Wetter, Anthony, Lee, Gilbert, Diaz, Tiffany, Garrison, Jorge D, Brioni
Publikováno v:
European journal of pharmacology. 684(1-3)
Histamine H(3) receptor antagonists have been widely reported to improve performance in preclinical models of cognition, but more recently efficacy in pain models has also been described. Here, A-960656 ((R)-2-(2-(3-(piperidin-1-yl)pyrrolidin-1-yl)be
Publikováno v:
Journal of Molecular Biology. 220:621-629
Integrative recombination of bacteriophage lambda requires perfect homology between partners over a short segment of DNA, the overlap region, that separates the positions of top and bottom strand exchange. We constructed a specific cross-link between
Autor:
Marlon Cowart, Stephen J. Benkovic
Publikováno v:
Biochemistry. 30:788-796
A novel method using combined chemical and enzymatic reactions to allow the preparation of covalently cross-linked DNA duplexes has been described. The method can be used to specifically link two complementary bases of a DNA duplex containing all fou
Autor:
Stephen J. Benkovic, Peter E. Wright, John Cavanagh, Marlon Cowart, C. Robert Matthews, Arthur G. Palmer, Christopher J. Falzone
Publikováno v:
Journal of biomolecular NMR. 4(3)
By using fully 15N- and 15N/13C-labeled Escherichia coli dihydrofolate reductase, the sequence-specific 1H and 15N NMR assignments were achieved for 95% of the backbone resonances and for 90% of the 13C alpha resonances in the binary folate complex.