Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE

Autor: Uta E. Höpken, Jon D. Laman, Rogier Q. Hintzen, Knut Biber, Hendrikus Boddeke, Marjan van Meurs, Marie-José Melief, Sandra Amor, Leonie A. Boven, Bert A. 't Hart, Ingo Bechmann, Ruth Huizinga, Annet F Wierenga-Wolf, Andreas Meisel, Marloes van Zwam, Jane S. A. Voerman, Christian Meisel

Publikováno v: van Zwam, M, Huizinga, R, Melief, M J, Wierenga-Wolf, A F, van Meurs, M, Voerman, J S, Biber, K P H, Boddeke, H W G M, Hopken, U E, Meisel, C, Meisel, A, Bechmann, I, Hintzen, R Q, Hart, B A, Amor, S, Laman, J D & Boven, L A 2009, ' Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE ', Journal of Molecular Medicine, vol. 87, no. 3, pp. 273-286 . https://doi.org/10.1007/s00109-008-0421-4
Journal of Molecular Medicine, 87(3), 273-286. Springer-Verlag
Journal of Molecular Medicine, 87(3), 273-286. Springer Verlag
Journal of Molecular Medicine, 87(3), 273-286. SPRINGER HEIDELBERG

Drainage of central nervous system (CNS) antigens to the brain-draining cervical lymph nodes (CLN) is likely crucial in the initiation and control of autoimmune responses during multiple sclerosis (MS). We demonstrate neuronal antigens within CLN of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6d5160ed55fa710dce32471ddd1321
https://doi.org/10.1007/s00109-008-0421-4

[Plasma urea along with every plasma creatinine test?]

Autor: Marloes, van Zwam, Jack F M, Wetzels, Hans L, Willems

Publikováno v: Nederlands tijdschrift voor geneeskunde. 157(46)

The concentration of plasma creatinine and the estimated glomerular filtration rate, calculated from plasma creatinine, age, weight, and gender, are used to assess kidney function. In routine clinical practice the concentration of plasma urea is ofte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::91e93870be364b45ec2151f9a608bb2d
https://pubmed.ncbi.nlm.nih.gov/24220176

Myelin ingestion by macrophages promotes their motility and capacity to recruit myeloid cells

Autor: Benjamin Schrijver, Jon D. Laman, Annet F Wierenga-Wolf, Marloes van Zwam, Marie-José Melief, Leonie A. Boven

Publikováno v: Journal of Neuroimmunology, 225(1-2), 112-117. Elsevier

Myelin-laden macrophages reside within the CNS, the CSF and in the CNS-draining lymph nodes during MS and EAE, suggesting migration of these macrophages between these compartments and interaction with other cells. Since chemokines and their receptors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bea92eccc43ea30d0e584277edd081f
https://pubmed.ncbi.nlm.nih.gov/20605225

Tolerogenic effect of fiber tract injury: reduced EAE severity following entorhinal cortex lesion

Autor: Ulrike Gimsa, Orhan Aktas, Robert Nitsch, Erik Kwidzinski, Ingo Bechmann, Jacqueline Mahlo, Christine Brandt, Birgit Sawitzki, Leman Mutlu, Marloes van Zwam, Jon D. Laman

Publikováno v: Experimental Brain Research, 178(4), 542-553. Springer-Verlag

Despite transient, myelin-directed adaptive immune responses in regions of fiber tract degeneration, none of the current models of fiber tract injuries evokes disseminated demyelination, implying effective mechanisms maintaining or re-establishing im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ab67cc99d2dd0eabb711dc705ef2d5
https://pure.eur.nl/en/publications/8c668461-4fe6-40dc-81e2-f5317aea0e2c

Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis

Autor: Sandra Amor, Johannes M. F. G. Aerts, Leonie A. Boven, Rolf G. Boot, Marjan van Meurs, Edward E. S. Nieuwenhuis, Annet F Wierenga-Wolf, Marloes van Zwam, Jon D. Laman, Rogier Q. Hintzen

Publikováno v: Brain, 129(Pt 2), 517-26. Oxford University Press
Brain, 129(Part 2), 517-526. Oxford University Press
Brain, 129(Pt 2), 517-526. Oxford University Press
ResearcherID
Boven, L A, Van Meurs, M, Van Zwam, M, Wierenga-Wolf, A, Hintzen, R Q, Boot, R G, Aerts, J M, Amor, S, Nieuwenhuis, E E & Laman, J D 2006, ' Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis ', Brain, vol. 129, no. Pt 2, pp. 517-26 . https://doi.org/10.1093/brain/awh707

Multiple sclerosis lesion activity concurs with the extent of inflammation, demyelination and axonal suffering. Pro-inflammatory myeloid cells contribute to lesion development, but the self-limiting nature of lesions implies as yet unidentified anti-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9efb40a44f62ee506607e86f448b6f
https://doi.org/10.1093/brain/awh707