Machine learning identifies a profile of inadequate responder to methotrexate in rheumatoid arthritis

Autor: Julien Duquesne, Vincent Bouget, Paul Henry Cournède, Bruno Fautrel, Francis Guillemin, Pascal H P de Jong, Judith W Heutz, Marloes Verstappen, Annette H M van der Helm-van Mil, Xavier Mariette, Samuel Bitoun

Publikováno v: Rheumatology
Rheumatology, 2023, ⟨10.1093/rheumatology/keac645⟩
Rheumatology. OXFORD UNIV PRESS

Objectives Around 30% of patients with RA have an inadequate response to MTX. We aimed to use routine clinical and biological data to build machine learning models predicting EULAR inadequate response to MTX and to identify simple predictive biomarke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62b582b03f120eb45301dc044f2965d
https://hal.science/hal-03986625/file/3071.pdf

Joint Damage Over Time in Patients With Early Rheumatoid Arthritis Follows Trajectories Related to Distinct Courses of Disease Activity

Autor: Quirine A. Dumoulin, Marloes Verstappen, Annette H.M. van der Helm-van Mil, Hanna W. van Steenbergen

Publikováno v: The Journal of rheumatology, 50(4), 573-575. Journal of Rheumatology

The severity of radiographic joint destruction in rheumatoid arthritis (RA) has decreased greatly in the last decades because of improved treatments and treatment strategies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4beb3730b8985fad86897abf47c522f
https://pure.eur.nl/en/publications/73b8c932-b21f-4ce9-a75b-c5ba650516e6

An ultrasound negative for subclinical synovitis in arthralgia patients: is it helpful in identifying those not developing arthritis?

Autor: Cleo Rogier, Giulia Frazzei, Marion C Kortekaas, Marloes Verstappen, Sarah Ohrndorf, Elise van Mulligen, Ronald F van Vollenhoven, Dirkjan van Schaardenburg, Pascal H P de Jong, Annette H M van der Helm-van Mil

Publikováno v: Rheumatology (Oxford, England), 61(12), 4892-4897. Oxford University Press
Rogier, C, Frazzei, G, Kortekaas, M C, Verstappen, M, Ohrndorf, S, van Mulligen, E, van Vollenhoven, R F, van Schaardenburg, D, de Jong, P H P & van der Helm-van Mil, A H M 2022, ' An ultrasound negative for subclinical synovitis in arthralgia patients : is it helpful in identifying those not developing arthritis? ', Rheumatology (Oxford, England), vol. 61, no. 12, pp. 4892-4897 . https://doi.org/10.1093/rheumatology/keac239

Objective To investigate the negative predictive value (NPV) of musculoskeletal US (MSUS) in arthralgia patients at risk for developing inflammatory arthritis. Methods An MSUS examination of hands and feet was performed in arthralgia patients at risk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2450ecc84629f754919a0c63fa2c16
https://pure.amc.nl/en/publications/an-ultrasound-negative-for-subclinical-synovitis-in-arthralgia-patients(a13486d4-3ac3-405c-a46b-7194757a87bc).html

ACPA-negative and ACPA-positive RA patients achieving disease resolution demonstrate distinct patterns of MRI-detected joint-inflammation

Autor: Marloes Verstappen, Xanthe M E Matthijssen, Sean E Connolly, Michael A Maldonado, Tom W J Huizinga, Annette H M van der Helm-van Mil

Publikováno v: Rheumatology, 62(1), 124-134. OXFORD UNIV PRESS

Objectives Although sustained DMARD-free remission (SDFR; sustained absence of clinical-synovitis after DMARD-discontinuation) is increasingly achievable in RA, prevalence differs between ACPA-negative (40%) and ACPA-positive RA (5–10%). Additional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2141cefce39eba8976be589b72df9ee3
https://hdl.handle.net/1887/3458788

Hand and foot MRI in contemporary undifferentiated arthritis: in which patients is MRI valuable to detect rheumatoid arthritis early? A large prospective study

Autor: Nikolet K den Hollander, Marloes Verstappen, Navkiran Sidhu, Elise van Mulligen, Monique Reijnierse, Annette H M van der Helm-van Mil

Publikováno v: Rheumatology, 61(10), 3963-3973. OXFORD UNIV PRESS
Rheumatology (Oxford, England), 61(10), 3963-3973. Oxford University Press

Objectives Identifying patients that will develop RA among those presenting with undifferentiated arthritis (UA) remains a clinical dilemma. Although MRI is helpful according to EULAR recommendations, this has only been determined in UA patients not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e581304a2cf1ed4cd5697f926c3178
https://pubmed.ncbi.nlm.nih.gov/35022703