C-type lectin-like molecule-1 (CLL1)-targeted TRAIL augments the tumoricidal activity of granulocytes and potentiates therapeutic antibody-dependent cell-mediated cytotoxicity

Autor: Yunwei Wei, Valerie R. Wiersma, Marloes J. M. Gooden, Wijnand Helfrich, Djoke Hendriks, Hans W. Nijman, Douwe F. Samplonius, Jin Zhou, Maartje C.A. Wouters, Marco de Bruyn, Ce Shi, Edwin Bremer

Publikováno v: mAbs, 7(2), 321-330

The therapeutic effect of anti-cancer monoclonal antibodies stems from their capacity to opsonize targeted cancer cells with subsequent phagocytic removal, induction of antibody-dependent cell-mediated cytotoxicity (ADCC) or induction of complement-m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9b7186caea380630edef5837f8fca9
https://doi.org/10.1080/19420862.2015.1007811

The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis

Autor: Ninke Leffers, Marloes J. M. Gooden, Hans W. Nijman, Toos Daemen, de Truuske Bock

Publikováno v: British Journal of Cancer

BACKGROUND: Tumour- infiltrating lymphocytes (TILs) are often found in tumours, presumably reflecting an immune response against the tumour. We carried out a systematic review and meta-analysis, aiming to establish pooled estimates for survival outco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9a73221d528f9f6bb30ee2b908413f
https://doi.org/10.1038/bjc.2011.189

Down-regulation of proteasomal subunit MB1 is an independent predictor of improved survival in ovarian cancer

Autor: Harry Hollema, Anna A. Mokhova, Marloes J. M. Gooden, Klaske A. ten Hoor, Hans W. Nijman, Ninke Leffers, Ate G.J. van der Zee, H. Marike Boezen, Toos Daemen, W. Martin Kast

Publikováno v: Gynecologic Oncology, 113(2), 256-263. ACADEMIC PRESS INC ELSEVIER SCIENCE

OBJECTIVE: To investigate the expression and to determine the prognostic impact of components of the antigen processing and presentation pathway (APPP) in ovarian cancer.METHODS: Expression of MB1, LMP7, TAP1, TAP2, ERp57, ERAP1, beta(2)-microglobuli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7047d3d3bc460ee7acc3b4a9a990d764
https://doi.org/10.1016/j.ygyno.2008.12.030

Galectin-9 Activates and Expands Human T-Helper 1 Cells

Autor: Paul Eggleton, Valerie R. Wiersma, Toshiro Niki, Marloes J. M. Gooden, Hans W. Nijman, Edwin Bremer, Mitsuomi Hirashima, Jurjen Gerssen, Wijnand Helfrich, Robert J. van Ginkel, Douwe F. Samplonius

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e65616 (2013)
PLoS ONE, 8(5):e65616. PUBLIC LIBRARY SCIENCE
PLoS ONE

Galectin-9 (Gal-9) is known for induction of apoptosis in IFN-gamma and IL-17 producing T-cells and amelioration of autoimmunity in murine models. On the other hand, Gal-9 induced IFN-gamma positive T-cells in a sarcoma mouse model and in food allerg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1524e3d7ed681c2c640e7cf51ace700
https://doi.org/10.1371/journal.pone.0065616

HLA-E expression by gynecological cancers restrains tumor-infiltrating CD8(+) T lymphocytes

Autor: Marloes J. M. Gooden, J. Baptist Trimbos, Sjoerd H. van der Burg, Thorbald van Hall, Hans W. Nijman, Ninke Leffers, Ekaterina S. Jordanova, Margit H Lampen

Publikováno v: Proceedings of the National Academy of Sciences, 108(26), 10656-10661
Proceedings of the National Academy of Sciences of the United States of America, 108(26), 10656-10661. NATL ACAD SCIENCES

HLA-E is a nonclassical HLA class I molecule, which differs from classical HLA molecules by its nonpolymorphic, conserved nature. Expression and function of HLA-E in normal tissues and solid tumors is not fully understood. We investigated HLA-E prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d0b30fd593efbf8a5fe522ef933a6c
https://hdl.handle.net/1887/109068