Dose Regimen Rationale for Panitumumab in Cancer Patients: To Be Based on Body Weight or Not

Autor: Hans Prenen, Michael Z Liao, Sandeep Dutta, Marloes Berkhout, Vijay V. Upreti

Publikováno v: Clinical Pharmacology: Advances and Applications. 12:109-114

Introduction Body weight can affect exposure, safety and efficacy of antibody-based therapies; sometimes these effects may not be clinically relevant. Panitumumab is approved for wild-type RAS metastatic colorectal cancer, using a body weight-based d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8df81901b9423e891f096b13be443088
https://doi.org/10.2147/cpaa.s262949

Impact of Primary Tumour Location and Early Tumour Shrinkage on Outcomes in Patients with RAS Wild-Type Metastatic Colorectal Cancer Following First-Line FOLFIRI Plus Panitumumab

Autor: Reija Koukakis, Meinolf Karthaus, Laurent Mineur, Marloes Berkhout, Javier Gallego, Josef Thaler, Ralf-Dieter Hofheinz, Marc Van den Eynde, Claus-Henning Köhne

Publikováno v: Drugs in R&D, Vol. 19, no.3, p. 267-275 (2019)
Drugs in R&D
Drugs in R&D, Vol 19, Iss 3, Pp 267-275 (2019)

Objective Data from a trial of first-line panitumumab plus FOLFIRI (folinic acid, infusional 5-fluorouracil and irinotecan) in metastatic colorectal cancer were retrospectively analysed to investigate the effects of primary tumour location and early

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf97ef1339f5544db672bd33fc1bb01b
https://hdl.handle.net/2078.1/237261

COX-2 Polymorphisms in Patients With Familial Adenomatous Polyposis

Autor: Hennie M.J. Roelofs, Fokko M. Nagengast, Elisabeth M. H. Mathus-Vliegen, Marloes Berkhout, Wilbert H.M. Peters, Rene H. M. te Morsche

Publikováno v: Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics. 17:347-351

Cyclooxygenase-2 (COX-2) is an enzyme involved in the synthesis of prostaglandins and thromboxanes, which are regulators of biologic processes such as inflammation, cell proliferation, and angiogenesis. COX-2 has been found overexpressed in (pre)mali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9fa896a392e3a01d8b71145735dd562
https://doi.org/10.3727/096504009788428451

Chromosomal and methylation alterations in sporadic and familial adenomatous polyposis-related duodenal carcinomas

Autor: Marieke Dekkers, Iris D. Nagtegaal, Fred J. J. M. van de Molengraft, J. Han van Krieken, Judith W. M. Jeuken, Marloes Berkhout, Fokko M. Nagengast, Sandra J B Cornelissen, Wilbert H.M. Peters

Publikováno v: Modern Pathology, 20, 1253-62
Modern Pathology, 20, 12, pp. 1253-62

Contains fulltext : 52234.pdf (Publisher’s version ) (Closed access) Primary carcinomas of the small intestine are rare and the mechanism of their pathogenesis is poorly understood. Patients with familial adenomatous polyposis (FAP) have a high ris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32e48aa29a985542c7309c4c2ad4219
https://hdl.handle.net/2066/52234

Expression of CD45RB functionally distinguishes intestinal T lymphocytes in inflammatory bowel disease

Autor: Tessa ten Hove, F Olle The, Marloes Berkhout, Joost P Bruggeman, Florry A Vyth-Dreese, J Frederik M Slors, Sander J H van Deventer, Anje A te Velde

Publikováno v: Journal of leukocyte biology, 75(6), 1010-1015. FASEB
Journal of Leukocyte Biology, 75, 6, pp. 1010-5
Journal of Leukocyte Biology, 75, 1010-5

Contains fulltext : 58498.pdf (Publisher’s version ) (Open Access) The importance of CD45RB expression on T cells was already shown in mice where CD45RB(high) expression determines pathogenic potential. In this study, we analyzed the expression of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4352dc8a25b0d795ea63f4ef566ab65
https://hdl.handle.net/2066/58498