Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Marlinde L. van den Boogaard"'
Autor:
Lindy Vernooij, Alvin Kamili, Kimberley Ober, Jennemiek van Arkel, Lina Lankhorst, Enya Vermeulen, Hanin Al-Khakany, Gabor Tax, Marlinde L. van den Boogaard, Jamie I. Fletcher, Selma Eising, Jan J. Molenaar, M. Emmy M. Dolman
Publikováno v:
EJC Paediatric Oncology, Vol 3, Iss , Pp 100168- (2024)
Background: Neuroblastoma is the most common extracranial pediatric solid malignancy with high-risk patients showing survival rates less than 50 %. These tumors frequently escape apoptosis through upregulation of the anti-apoptotic protein BCL-2. Unf
Externí odkaz:
https://doaj.org/article/248810243e214da890e1924fb4d60647
Autor:
Kaylee M. Keller, Joost Koetsier, Linda Schild, Vicky Amo-Addae, Selma Eising, Kim van den Handel, Kimberley Ober, Bianca Koopmans, Anke Essing, Marlinde L. van den Boogaard, Karin P. S. Langenberg, Natalie Jäger, Marcel Kool, Stefan Pfister, M. Emmy M. Dolman, Jan J. Molenaar, Sander R. van Hooff
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Pediatric cancer is the leading cause of disease-related death in children and the need for better therapeutic options remains urgent. Due to the limited number of patients, target and drug development for pediatrics is often supp
Externí odkaz:
https://doaj.org/article/89c1cc504cdf4e7d978144628845f2f7
Autor:
Sally L George, Federica Lorenzi, David King, Sabine Hartlieb, James Campbell, Helen Pemberton, Umut H Toprak, Karen Barker, Jennifer Tall, Barbara Martins da Costa, Marlinde L van den Boogaard, M Emmy M Dolman, Jan J Molenaar, Helen E Bryant, Frank Westermann, Christopher J Lord, Louis Chesler
Publikováno v:
EBioMedicine, Vol 59, Iss , Pp 102971- (2020)
Background: In neuroblastoma, genetic alterations in ATRX, define a distinct poor outcome patient subgroup. Despite the need for new therapies, there is a lack of available models and a dearth of pre-clinical research. Methods: To evaluate the impact
Externí odkaz:
https://doaj.org/article/43e6d2e114774272b2793ae20c2d02f1
Autor:
Michael R. Van Gerven, Linda Schild, Jennemiek van Arkel, Bianca Koopmans, Luuk A. Broeils, Loes A. Meijs, Romy van Oosterhout, Max M. van Noesel, Jan Koster, Sander R. van Hooff, Jan J. Molenaar, Marlinde L. van den Boogaard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8598ab6f5e60b2977e7edeee608618a
https://doi.org/10.15252/rc.2023451245
https://doi.org/10.15252/rc.2023451245
Autor:
Rabi Tawil, Richard J.L.F. Lemmers, Iris M Willemsen, Marlinde L. van den Boogaard, Ignazio Maggio, Nienke van der Stoep, Manuel A F V Gonçalves, Niels Geijsen, Patrick J. van der Vliet, Judit Balog, Stephen J. Tapscott, Rob C. Hoeben, Julie Schouten, Remko Goossens, Sabrina Sacconi, Silvère M. van der Maarel
Publikováno v:
Journal of Medical Genetics, 56(12), 828-837. BMJ PUBLISHING GROUP
Journal of Medical Genetics, 56(12), 828-837. BMJ Publishing Group
Journal of Medical Genetics, 56(12), 828. BMJ Publishing Group
Journal of Medical Genetics, 56(12), 828-837. BMJ Publishing Group
Journal of Medical Genetics, 56(12), 828. BMJ Publishing Group
BackgroundFacioscapulohumeral dystrophy (FSHD) is associated with partial chromatin relaxation of the DUX4 retrogene containing D4Z4 macrosatellite repeats on chromosome 4, and transcriptional de-repression of DUX4 in skeletal muscle. The common form
Autor:
Nil A. Schubert, Sander R. van Hooff, Linda Schild, Kimberley Ober, Marjolein Hortensius, Kim van den Handel, Anke H.W. Essing, Bianca Koopmans, Manon Boeije, Natalie Proost, Marieke van de Ven, Selina Jansky, Sabine A. Stainczyk, Umut H. Toprak, Frank Westermann, Selma Eising, Jan J. Molenaar, Marlinde L. van den Boogaard
Publikováno v:
bioRxiv
Homozygous inactivation of the CDKN2A locus is one of the most common genomic aberrations in human cancer. The locus codes for two unrelated and distinctly regulated proteins: p14ARF and p16INK4a, which inhibit MDM2 and CDK4/6, respectively. Loss of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9d40a29722a1f30d92c3ace3cc4803
https://zenodo.org/record/5912979
https://zenodo.org/record/5912979
Autor:
Marlinde L. van den Boogaard, Helen N. Pemberton, Jennifer R. Tall, Sabine Hartlieb, Helen E. Bryant, James Campbell, Barbara Martins da Costa, Sally L. George, Christopher J. Lord, Federica Lorenzi, Louis Chesler, Umut H. Toprak, David A. King, Jan J. Molenaar, Karen Barker, M. Emmy M. Dolman, Frank Westermann
Publikováno v:
EBioMedicine, Vol 59, Iss, Pp 102971-(2020)
EBioMedicine
EBioMedicine, 59. Elsevier BV
EBioMedicine
EBioMedicine, 59. Elsevier BV
Background In neuroblastoma, genetic alterations in ATRX, define a distinct poor outcome patient subgroup. Despite the need for new therapies, there is a lack of available models and a dearth of pre-clinical research. Methods To evaluate the impact o
Autor:
Francesco Licciardi, Marlinde L. van den Boogaard, Davide Montin, Pier-Angelo Tovo, Marta Delle Piane
Publikováno v:
Journal of Clinical Immunology, 39, 234-236
Journal of Clinical Immunology, 39, 3, pp. 234-236
Journal of Clinical Immunology, 39, 3, pp. 234-236
Item does not contain fulltext
Autor:
Remko, Goossens, Marlinde L, van den Boogaard, Richard J L F, Lemmers, Judit, Balog, Patrick J, van der Vliet, Iris M, Willemsen, Julie, Schouten, Ignazio, Maggio, Nienke, van der Stoep, Rob C, Hoeben, Stephen J, Tapscott, Niels, Geijsen, Manuel A F V, Gonçalves, Sabrina, Sacconi, Rabi, Tawil, Silvère M, van der Maarel
Publikováno v:
Journal of medical genetics. 56(12)
Facioscapulohumeral dystrophy (FSHD) is associated with partial chromatin relaxation of theWe employed whole exome sequencing combined with Sanger sequencing to screen uncharacterised FSHD2 patients for extra-exonicWe identified intronicThe estimated
Autor:
Judit Balog, Richard J.L.F. Lemmers, Marlinde L. van den Boogaard, Kirsten R. Straasheijm, Peter E. Thijssen, Stephen J. Tapscott, Rabi Tawil, Silvère M. van der Maarel, Sean C. Shadle, Yvonne D. Krom, Patrick J. van der Vliet, Annika de Jong
Publikováno v:
Epigenetics
Facioscapulohumeral muscular dystrophy is caused by incomplete epigenetic repression of the transcription factor DUX4 in skeletal muscle. A copy of DUX4 is located within each unit of the D4Z4 macrosatellite repeat array and its derepression in somat