Výsledky vyhledávání - "Marlin H. Dehoff"

Ethanol up-regulates nucleus accumbens neuronal activity dependent pentraxin (Narp): Implications for alcohol-induced behavioral plasticity

Autor: Paul F. Worley, Karen K. Szumlinski, Deborah A. Finn, Debra K. Cozzoli, Marlin H. Dehoff, Alexis W. Ary, John C. Crabbe

Publikováno v: Alcohol. 46:377-387

Neuronal activity-dependent pentraxin (Narp) interacts with α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) glutamate receptors to facilitate excitatory synapse formation by aggregating them at established synapses. Alcohol is well-charact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea74b0273fa98a8dd38a495904280440
https://doi.org/10.1016/j.alcohol.2011.10.003

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Localization and Expression of Group I Metabotropic Glutamate Receptors in the Mouse Striatum, Globus Pallidus, and Subthalamic Nucleus: Regulatory Effects of MPTP Treatment and Constitutive Homer Deletion

Autor: Teiichi Furuichi, Yoland Smith, Marlin H. Dehoff, Paul F. Worley, Randy A. Hall, Masaaki Kuwajima

Publikováno v: Journal of Neuroscience. 27:6249-6260

Group I metabotropic glutamate receptors (mGluRs), mGluR1 and mGluR5, regulate activity in the globus pallidus (GP) and subthalamic nucleus (STN). To test whether the localization of group I mGluRs is altered in parkinsonism, we used immunoelectron m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55835dd9985805c2c0fc76224b3f86b5
https://doi.org/10.1523/jneurosci.3819-06.2007

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Ca2+ Signaling in Microdomains

Autor: Guojin Huang, Weizhong Zeng, Kristine E. Kamm, Shmuel Muallem, Joo Young Kim, Yusuke Mizuno, Paul F. Worley, Marlin H. Dehoff

Publikováno v: Journal of Biological Chemistry. 282:14283-14290

Excitation-contraction (E-C) coupling and Ca2+-induced Ca2+ release in smooth and cardiac muscles is mediated by the L-type Ca2+ channel isoform Cav1.2 and the ryanodine receptor isoform RyR2. Although physical coupling between Cav1.1 and RyR1 in ske

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::413b4cb1a517e6de007031aa0351702f
https://doi.org/10.1074/jbc.m611529200

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Complex, multimodal behavioral profile of theHomer1knockout mouse

Autor: Martin K. Schwarz, Marlin H. Dehoff, P. J. Jaubert, Y. Y. Lo, Peter H. Seeburg, Mari S. Golub, S. L. Germann, Paul F. Worley, Shin H. Kang, Robert F. Berman

Publikováno v: Genes, Brain and Behavior

Proteins of the Homer1 immediate early gene family have been associated with synaptogenesis and synaptic plasticity suggesting broad behavioral consequences of loss of function. This study examined the behavior of male Homer1 knockout (KO) mice compa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12df28448d21fbfa557c82058f7181fb
https://doi.org/10.1111/j.1601-183x.2006.00240.x

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Homer2 Is Necessary for EtOH-Induced Neuroplasticity

Autor: Peter W. Kalivas, Ashley R. Mason, Erik B. Oleson, Lawrence D. Middaugh, Stephanie Cagle, Karen K. Szumlinski, Kristine Welt, Marlin H. Dehoff, Matthew J. During, Matthias Klugman, Jennifer K. Walker, Paul F. Worley, Kevin D. Lominac

Publikováno v: The Journal of Neuroscience. 25:7054-7061

Homer proteins are integral to the assembly of proteins regulating glutamate signaling and synaptic plasticity. ConstitutiveHomer2gene deletion [knock-out (KO)] and rescue with adeno-associated viral (AAV) transfection ofHomer2bwas used to demonstrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1ea408973cb936b675b15d85d2c38b3
https://doi.org/10.1523/jneurosci.1529-05.2005

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Homer Proteins Regulate Sensitivity to Cocaine

Autor: Stephanie E. Shealy, Jian C. Tu, Shigenobu Toda, Lawrence D. Middaugh, Marlin H. Dehoff, Paul F. Worley, Thomas L. Berry, Shin H. Kang, Matthias Klugmann, Matthew J. During, Peter W. Kalivas, William C. Griffin, Kevin D. Lominac, Kelly A. Frys, Nicolas P. Champtiaux, Jason Rohrer, Karen K. Szumlinski

Publikováno v: Neuron. 43:401-413

Drug addiction involves complex interactions between pharmacology and learning in genetically susceptible individuals. Members of the Homer gene family are regulated by acute and chronic cocaine administration. Here, we report that deletion of Homer1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26788dfa4c5f5a681434be736b1c180c
https://doi.org/10.1016/j.neuron.2004.07.019

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Homer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 Receptors

Autor: Shmuel Muallem, Shin H. Kang, Dong Ming Shin, Marlin H. Dehoff, Peter H. Seeburg, Martin K. Schwarz, Nikolay Shcheynikov, Kirill Kiselyov, Joseph P. Yuan, Paul F. Worley, Jin Chen

Publikováno v: Cell

Receptor signaling at the plasma membrane often releases calcium from intracellular stores. For example, inositol triphosphate (IP3) produced by receptor-coupled phospholipase C activates an intracellular store calcium channel, the IP(3)R. Conversely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9015994586d5b56e701a780bf4684e38
https://doi.org/10.1016/s0092-8674(03)00716-5

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Homer 2 tunes G protein–coupled receptors stimulus intensity by regulating RGS proteins and PLCβ GAP activities

Autor: Shmuel Muallem, Surendra K. Nayak, Dong Min Shin, Paul F. Worley, Marlin H. Dehoff, Shin H. Kang, Jiangchen Tu, Elliott M. Ross, Xiang Luo

Publikováno v: The Journal of Cell Biology

Homers are scaffolding proteins that bind G protein–coupled receptors (GPCRs), inositol 1,4,5-triphosphate (IP3) receptors (IP3Rs), ryanodine receptors, and TRP channels. However, their role in Ca2+ signaling in vivo is not known. Characterization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352fa5049c378873ff6bd46c1bedc691
https://doi.org/10.1083/jcb.200210109

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An Intronic Silencer Regulates B Lymphocyte Cell- and Stage-Specific Expression of the Human Complement Receptor Type 2 (CR2, CD21) Gene

Autor: Karen W. Makar, Christine T. N. Pham, Marlin H. Dehoff, Siobhan M. O’Connor, Susan M. Jacobi, V. Michael Holers

Publikováno v: The Journal of Immunology. 160:1268-1278

Human CR2 (CD21) is a B lymphocyte protein whose surface expression is restricted primarily to the mature cell stage during development. To study the transcriptional mechanisms that govern cell- and stage-restricted CR2 expression, we first performed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::139acfe655b3c0b0d197508bf40cbfb8
https://doi.org/10.4049/jimmunol.160.3.1268

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Homers at the Interface between Reward and Pain

Autor: Adam T. Gould, Ilona Obara, Peter H. Seeburg, Paul F. Worley, Ping Wu Zhang, Scott P. Goulding, Bo Xiao, Matthias Klugmann, Kevin D. Lominac, Marlin H. Dehoff, Georg von Jonquieres, Jia Hua Hu, Karen K. Szumlinski

Publikováno v: Frontiers in Psychiatry
Scopus-Elsevier
Frontiers in Psychiatry, Vol 4 (2013)
Frontiers in psychiatry, 2013, Vol.4, pp.39 [Peer Reviewed Journal]

Pain alters opioid reinforcement, presumably via neuroadaptations within ascending pain pathways interacting with the limbic system. Nerve injury increases expression of glutamate receptors and their associated Homer scaffolding proteins throughout t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57df0df62696e0cc548f71d905d72098
https://pubmed.ncbi.nlm.nih.gov/23761764

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