Výsledky vyhledávání - "Marlijn Waaijers"

Dopamine D2 receptor expression in the corticotroph cells of the human normal pituitary gland

Autor: Annamaria Colao, Steven W. J. Lamberts, Leo J. Hofland, Cristina de Angelis, Alessia Cozzolino, Rosario Pivonello, Johan M. Kros, Marlijn Waaijers, Claudia Pivonello

Publikováno v: Endocrine, 57(2), 314-325. Humana Press

The dopamine D2 receptor is the main dopamine receptor expressed in the human normal pituitary gland. The aim of the current study was to evaluate dopamine D2 receptor expression in the corticotroph cell populations of the anterior lobe and pars inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba98ea84499661a34d3f4150ea321e63
https://hdl.handle.net/1765/93762

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Characterization of the mTOR pathway in human normal adrenal and adrenocortical tumors

Autor: Annamaria Colao, Wouter W. de Herder, Leo J. Hofland, Maria Cristina De Martino, Joseph A M J L Janssen, Fadime Dogan, A. Marlijn Waaijers, Peter M. van Koetsveld, Claudia Pivonello, Rosario Pivonello, Ronald R. de Krijger, Richard A Feelders, Steven W. J. Lamberts

Publikováno v: Endocrine-Related Cancer, 21(4), 601-613. Bioscientifica Ltd

The mTOR pathway has recently been suggested as a new potential target for therapy in adrenocortical carcinomas (ACCs). The aim of the current study is to describe the expression of the mTOR pathway in normal adrenals (NAs) and pathological adrenals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7ecde47677d7e78aefbf1e8d683d69
https://doi.org/10.1530/erc-13-0112

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IGF and mTOR pathway expression and in vitro effects of linsitinib and mTOR inhibitors in adrenocortical cancer

Autor: Leo J. Hofland, Maria Cristina De Martino, Claudia Pivonello, Ronald R. de Krijger, Annamaria Colao, Richard A Feelders, Fadime Dogan, Wouter W. de Herder, Davine Hofste op Bruinink, Rosario Pivonello, Peter M. van Koetsveld, Joseph A M J L Janssen, A. Marlijn Waaijers

Publikováno v: Endocrine, 64(3), 673. Humana Press
Endocrine
Endocrine, 64(3), 673-684. Humana Press

Purpose: The IGF and mTOR-pathways are considered as potential targets for therapy in patients with adrenocortical carcinoma (ACC). This study aims to describe the IGF pathway in ACC and to explore the response to the combined treatment with the IGF1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e664a73597dab36b56afbde9987ac12b
https://hdl.handle.net/1874/392071

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IFN-beta is a highly potent inhibitor of gastroenteropancreatic neuroendocrine tumor cell growth in vitro

Autor: Leo J. Hofland, Annamaria Colao, Marlijn Waaijers, Ed Croze, Wouter W. de Herder, Giovanni Vitale, Wenda Schoordijk, Steven W. J. Lamberts, Peter M. van Koetsveld

Publikováno v: Cancer Research, 66(1), 554-562. American Association for Cancer Research Inc.

IFN-α controls hormone secretion and symptoms in human gastroenteropancreatic neuroendocrine tumors (GEP-NET) but it rarely induces a measurable tumor size reduction. The effect of other type I IFNs, e.g., IFN-β, has not been evaluated. We compared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119fac356f5f069e87521193d861ab16
https://pure.eur.nl/en/publications/2874daed-6391-47e7-8416-731ad096220a

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The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5

Autor: Diana Sprij-Mooij, Joost van der Hoek, Marlijn Waaijers, Leo J. Hofland, Steven W. J. Lamberts, Maarten O. van Aken, Wouter W. de Herder, Gisbert Weckbecker, Peter M. van Koetsveld, Christian Bruns, Richard A Feelders, Albert Beckers

Publikováno v: European Journal of Endocrinology, 152(4), 645-654. Bioscientifica Ltd

Objective: Currently, there is no effective medical treatment for patients with pituitary-dependent Cushing’s disease. A novel somatostatin (SS) analogue, named SOM230, with high binding affinity to SS receptor subtypes sst1, sst2, sst3 and sst5 wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1824eb0e0d8a844fbd265502b1f0ea9f
https://doi.org/10.1530/eje.1.01876

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The novel somatostatin analog SOM230 is a potent inhibitor of hormone release by growth hormone- and prolactin-secreting pituitary adenomas in vitro

Autor: Leo J. Hofland, Gisbert Weckbecker, Aart-Jan van der Lely, Richard A Feelders, Marlijn Waaijers, Wouter W. de Herder, Peter M. van Koetsveld, Steven W. J. Lamberts, Diana Sprij-Mooij, Christian Bruns, Joost van der Hoek, Albert Beckers

Publikováno v: Journal of Clinical Endocrinology and Metabolism, 89(4), 1577-1585. Endocrine Society

To determine the inhibitory profile of the novel somatostatin (SRIF) analog SOM230 with broad SRIF receptor binding, we compared the in vitro effects of SOM230, octreotide (OCT), and SRIF-14 on hormone release by cultures of different types of secret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cd472a19986f8557daad1f6be2a17a
https://hdl.handle.net/1765/55379

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Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes

Autor: Peter M. van Koetsveld, Annamaria Colao, Leo J. Hofland, Marlijn Waaijers, Diego Ferone, P. Martin van Hagen, Rosario Pivonello, Steven W. J. Lamberts, Virgil A. S. H. Dalm, Diana M. Mooy, Francesco Minuto, Elgin G. R. Lichtenauer-Kaligis

Publikováno v: EUR Research Portal
Scopus-Elsevier
American Journal of Physiology, Endocrinology and Metabolism, 283(5), E1056-E1066. American Physiological Society

We recently demonstrated the expression of somatostatin (SS) and SS receptor (SSR) subtype 1 (sst1), sst2A, and sst3in normal human thymic tissue and of sst1and sst2Aon isolated thymic epithelial cells (TEC). We also found an inhibitory effect of SS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d239025c3323a6e91c5f21b912383d95
https://doi.org/10.1152/ajpendo.00205.2001

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Interferon-α-2a Is a Potent Inhibitor of Hormone Secretion by Cultured Human Pituitary Adenomas

Autor: P. Uitterlinden, Leo J. Hofland, Peter M. van Koetsveld, Wouter W. de Herder, J.M. Zuijderwijk, Marlijn Waaijers, Steven W. J. Lamberts

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 84:3336-3343

Interferon-alpha (IFN alpha) may exert direct inhibitory effects on cell proliferation and on the production of different peptide hormones. We investigated the effect of IFN alpha on hormone production by 15 GH-secreting pituitary adenomas, 4 clinica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69bf862abb058f79e6baa7ce10d65b30
https://doi.org/10.1210/jcem.84.9.6005

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Internalization of (DOTAo, 125I-Tyr3) octreotide by somatostatin receptor-positive cells in vitro and in vivo: implications for somatostatin receptor-targeted radioguided surgery

Autor: W. A. P. Breeman, Leo J. Hofland, Helmut R. Mäcke, E. P. Krenning, S. W. J. Lamberts, M. De Jong, P. M. van Koetsveld, Marlijn Waaijers

Publikováno v: Proceedings of the Association of American Physicians, 111(1), 63-69. Wiley-Blackwell Publishing Ltd

We compared internalization of three radioiodinated octreotide (OCT) somatostatin (SS) analogs-[125I-Tyr3]OCT, [DTPA degrees, 125I-Tyr3]OCT, and [DOTA degrees,125I-Tyr3]OCT-by somatostatin receptor (SSR)-positive mouse AtT20 pituitary tumor cells and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a78e543568875339fbcaa668d63c559
https://doi.org/10.1046/j.1525-1381.1999.09110.x

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Interferon-beta is a potent inhibitor of cell growth and cortisol production in vitro and sensitizes human adrenocortical carcinoma cells to mitotane

Autor: Peter M. van Koetsveld, Steven W. J. Lamberts, Ronald R. de Krijger, Wouter W. de Herder, Marlijn Waaijers, Johannes Hofland, Richard A Feelders, Ernst-Jan M. Speel, Leo J. Hofland, Giovanni Vitale, Diana Sprij-Mooij

Publikováno v: Endocrine-Related Cancer, 20(3), 443-454. BioScientifica Ltd.
Endocrine-Related Cancer, 20(3), 443-454. Bioscientifica Ltd

Adrenocortical carcinoma (ACC) is an aggressive tumor with very poor prognosis. Novel medical treatment opportunities are required. We investigated the effects of interferon-β (IFN-β), alone or in combination with mitotane, on cell growth and corti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5df69537abd98d0daf09a566a4a78f
https://cris.maastrichtuniversity.nl/en/publications/836fb65b-5673-4d4f-b50c-c367db283482

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