Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Marlies Oorts"'
Safety Assessment of Compounds after In Vitro Metabolic Conversion Using Zebrafish Eleuthero Embryos
Autor:
Arianna Giusti, Xuan-Bac Nguyen, Stanislav Kislyuk, Mélanie Mignot, Cecilia Ranieri, Johan Nicolaï, Marlies Oorts, Xiao Wu, Pieter Annaert, Noémie De Croze, Marc Léonard, Annelii Ny, Deirdre Cabooter, Peter de Witte
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 7, p 1712 (2019)
Zebrafish-based platforms have recently emerged as a useful tool for toxicity testing as they combine the advantages of in vitro and in vivo methodologies. Nevertheless, the capacity to metabolically convert xenobiotics by zebrafish eleuthero embryos
Externí odkaz:
https://doaj.org/article/8477ae5478d348fbbb6e72bd31d6b1a7
Autor:
Mathieu Vinken, Pieter Annaert, Sagnik Chatterjee, Axelle Cooreman, Lysiane Richert, Pieter Van Brantegem, Erwin Dreesen, Neel Deferm, Marlies Oorts
Bosentan, a well–known cholestatic agent, was not identified as cholestatic at concentrations up to 200 µM based on the drug-induced cholestasis (DIC) index value, determined in a sandwich-cultured human hepatocyte (SCHH)–based DIC assay. To obt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c217992b234cbd7bc6a7d4f08e3d953b
https://hdl.handle.net/20.500.14017/e05ae3dd-cdd5-4a09-8f8a-4cf98ecbca80
https://hdl.handle.net/20.500.14017/e05ae3dd-cdd5-4a09-8f8a-4cf98ecbca80
Autor:
Thomas Dufour, Greet Van den Berghe, Sarah Vander Perre, Sarah Derde, Marlies Oorts, Marc Jenniskens, Fabian Güiza, Steven Thiessen, Pieter Annaert, Lies Langouche
Publikováno v:
Shock (Augusta, Ga.)
Supplemental Digital Content is available in the text
Background and Aims: Elevated markers of cholestasis are common in response to critical illness, and associated with adverse outcome. The role of illness duration and of nutrient restriction
Background and Aims: Elevated markers of cholestasis are common in response to critical illness, and associated with adverse outcome. The role of illness duration and of nutrient restriction
Autor:
Vera Rogiers, Agapios Sachinidis, Umesh Chaudhari, Pieter Annaert, René P. Zahedi, Albert Sickmann, Xiaoqi Jiang, Marlies Oorts, Hector C. Keun, Eva Gijbels, Laxmikanth Kollipara, Eef Hoeben, Annette Kopp-Schneider, Jan G. Hengstler, Mathieu Vinken, Joery De Kock, Tamara Vanhaecke, Robim Marcelino Rodrigues
Publikováno v:
Archives of Toxicology. 92:1939-1952
Bosentan is well known to induce cholestatic liver toxicity in humans. The present study was set up to characterize the hepatotoxic effects of this drug at the transcriptomic, proteomic, and metabolomic levels. For this purpose, human hepatoma-derive
Publikováno v:
Drug Metabolism and Disposition. 46:697-703
Hepatic drug transporters play a pivotal role in the excretion of drugs from the body, in drug-drug interactions, as well as in drug-induced liver toxicity. Hepatocytes cultured in sandwich configuration are an advantageous model to investigate the i
Autor:
Pieter Annaert, Patrick Augustijns, Robin Adriaensen, Janneke Keemink, Marlies Oorts, Neel Deferm, Lysiane Richert
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 90:31-38
INTRODUCTION: Sandwich-cultured rat hepatocytes (SCRH) have become an invaluable in vitro model to study hepatic drug disposition. SCRH are maintained between two layers of extracellular matrix. In this configuration, culture periods of 4days are typ
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 149:296-307
Analytical strategies for detecting drugs in biological samples rely on information on metabolism and elimination. 5F-PY-PICA belongs to the group of synthetic cannabinoids that are known to undergo excretion into the bile. The aims of this study wer
Autor:
Anton Pohanka, Pieter Annaert, Dirk Kuypers, Jan de Hoon, Thomas Vanhove, Hylke de Jonge, Marlies Oorts, Henriette de Loor
CYP3A5 genotype is a major determinant of tacrolimus clearance, and has been shown to affect systemic tacrolimus metabolite/parent ratios in healthy volunteers, which may have implications for efficacy and toxicity. In a cohort of 50 renal transplant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b80f0f3319b6fb426acd687b56bda95
https://lirias.kuleuven.be/handle/123456789/627987
https://lirias.kuleuven.be/handle/123456789/627987
Safety Assessment of Compounds after In Vitro Metabolic Conversion Using Zebrafish Eleuthero Embryos
Autor:
Johan Nicolaï, Annelii Ny, Pieter Annaert, Arianna Giusti, Xuan-Bac Nguyen, Deirdre Cabooter, Stanislav Kislyuk, Cecilia Ranieri, Peter de Witte, Marc Léonard, Marlies Oorts, Mélanie Mignot, Xiao Wu, Noémie De Croze
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 7
International Journal of Molecular Sciences, MDPI, 2019, 20 (7), pp.1712. ⟨10.3390/ijms20071712⟩
International Journal of Molecular Sciences, Vol 20, Iss 7, p 1712 (2019)
Volume 20
Issue 7
International Journal of Molecular Sciences, MDPI, 2019, 20 (7), pp.1712. ⟨10.3390/ijms20071712⟩
International Journal of Molecular Sciences, Vol 20, Iss 7, p 1712 (2019)
Zebrafish-based platforms have recently emerged as a useful tool for toxicity testing as they combine the advantages of in vitro and in vivo methodologies. Nevertheless, the capacity to metabolically convert xenobiotics by zebrafish eleuthero embryos
Autor:
Pieter Annaert, Philippe Bachellier, Lysiane Richert, Bruno Heyd, Thomas Zacharias, Audrey Baze, Marlies Oorts
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 34
Drug-induced cholestasis (DIC) is recognized as one of the prime mechanisms for DILI. Hence, earlier detection of drug candidates with cholestatic signature is crucial. Recently, we introduced an in vitro model for DIC and evaluated its performance w