Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Marlies J W, Peeters"'
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Akademický článek
Ex vivo modulation of intact tumor fragments with anti-PD-1 and anti-CTLA-4 influences the expansion and specificity of tumor-infiltrating lymphocytes
Autor: Thomas Morgan Hulen, Christina Friese, Nikolaj Pagh Kristensen, Joachim Stoltenborg Granhøj, Troels Holz Borch, Marlies J. W. Peeters, Marco Donia, Mads Hald Andersen, Sine Reker Hadrup, Inge Marie Svane, Özcan Met
Publikováno v: Frontiers in Immunology, Vol 14 (2023)
Checkpoint inhibition (CPI) therapy and adoptive cell therapy with autologous tumor-infiltrating lymphocytes (TIL-based ACT) are the two most effective immunotherapies for the treatment of metastatic melanoma. While CPI has been the dominating therap
Externí odkaz: https://doaj.org/article/7afe16c86d48470cacf63c8ae355b95e
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4
Akademický článek
Patients With Myeloproliferative Neoplasms Harbor High Frequencies of CD8 T Cell-Platelet Aggregates Associated With T Cell Suppression
Autor: Ana Micaela Carnaz Simões, Morten Orebo Holmström, Pia Aehnlich, Anne Rahbech, Marlies J. W. Peeters, Aneta Radziwon-Balicka, Carlos Zamora, Tobias Wirenfeldt Klausen, Vibe Skov, Lasse Kjær, Christina Ellervik, Daniel El Fassi, Silvia Vidal, Hans Carl Hasselbalch, Mads Hald Andersen, Per thor Straten
Publikováno v: Frontiers in Immunology, Vol 13 (2022)
Myeloproliferative neoplasms (MPN) are chronic cancers of the hematopoietic stem cells in the bone marrow, and patients often harbor elevated numbers of circulating platelets (PLT). We investigated the frequencies of circulating PLT-lymphocyte aggreg
Externí odkaz: https://doaj.org/article/4d831d41a2bb43238209bbff284b2564
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5
Akademický článek
Mitochondrial-Linked De Novo Pyrimidine Biosynthesis Dictates Human T-Cell Proliferation but Not Expression of Effector Molecules
Autor: Marlies J. W. Peeters, Pia Aehnlich, Adriano Pizzella, Kasper Mølgaard, Tina Seremet, Özcan Met, Lene Juel Rasmussen, Per thor Straten, Claus Desler
Publikováno v: Frontiers in Immunology, Vol 12 (2021)
T-cell activation upon antigen stimulation is essential for the continuation of the adaptive immune response. Impairment of mitochondrial oxidative phosphorylation is a well-known disruptor of T-cell activation. Dihydroorotate dehydrogenase (DHODH) i
Externí odkaz: https://doaj.org/article/d07890576b8949e18e9b8caa7c3ef5cf
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6
Akademický článek
Small Molecule Inhibitors of MERTK and FLT3 Induce Cell Cycle Arrest in Human CD8+ T Cells
Autor: Richard M. Powell, Marlies J. W. Peeters, Anne Rahbech, Pia Aehnlich, Tina Seremet, Per thor Straten
Publikováno v: Vaccines, Vol 9, Iss 11, p 1294 (2021)
There is an increasing interest in the development of Receptor Tyrosine Kinases inhibitors (RTKIs) for cancer treatment, as dysregulation of RTK expression can govern oncogenesis. Among the newer generations of RTKIs, many target Mer Tyrosine Kinase
Externí odkaz: https://doaj.org/article/ea4b29a1d4364e7390284cee2fd8917d
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8
Mitochondrial-Linked
Autor: Marlies J W, Peeters, Pia, Aehnlich, Adriano, Pizzella, Kasper, Mølgaard, Tina, Seremet, Özcan, Met, Lene Juel, Rasmussen, Per, Thor Straten, Claus, Desler
Publikováno v: Frontiers in Immunology
T-cell activation upon antigen stimulation is essential for the continuation of the adaptive immune response. Impairment of mitochondrial oxidative phosphorylation is a well-known disruptor of T-cell activation. Dihydroorotate dehydrogenase (DHODH) i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7591fe8667bcc8377c476fb4cbf1ec2d
https://pubmed.ncbi.nlm.nih.gov/34899685
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