Role of Microbiota in Sexually Dimorphic Immunity

Autor: Marlies Elderman, Paul de Vos, Marijke Faas

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Sex differences in peripheral immune responses are well recognized. This is associated with sex differences in many immunological diseases. As the intestinal microbiota is known to influence the immune system, such sex differences in immune responses

Externí odkaz: https://doaj.org/article/23d415e7b5944d49a4c470db9b3ffb4d

Flexibility of Gut Microbiota in Ageing Individuals during Dietary Fiber Long-Chain Inulin Intake

Autor: E E Vaughan, Marijke M. Faas, S. El Aidy, P. de Vos, Mensiena B. G. Kiewiet, H Visser, Marlies Elderman, J G M Burgerhof

Publikováno v: Molecular Nutrition & Food Research. Wiley
Molecular Nutrition & Food Research

Scope During ageing, dysbiosis in the intestinal microbiota may occur and impact health. There is a paucity of studies on the effect of fiber on the elderly microbiota and the flexibility of the aged microbiota upon prebiotic intake. It is hypothesiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ae832dfad555603f9107c193d2e2f5
https://research.rug.nl/en/publications/e64d7a19-7fcd-46c9-9835-93aa41367677

Age-associated Impairment of the Mucus Barrier Function is Associated with Profound Changes in Microbiota and Immunity

Autor: Bruno Sovran, Mark V. Boekschoten, Paul de Vos, Jerry M. Wells, Floor Hugenholtz, Myrte Huijskes, Marlies Elderman, Huub F. J. Savelkoul, Adriaan A. van Beek, Jan Dekker, Katrine Graversen

Publikováno v: Scientific Reports 9 (2019) 1
Scientific Reports, 9(1)
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports, 9(1):1437. Nature Publishing Group
Scientific Reports

Aging significantly increases the vulnerability to gastrointestinal (GI) disorders but there are few studies investigating the key factors in aging that affect the GI tract. To address this knowledge gap, we used 10-week- and 19-month-old litter-mate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ab3da5e9682d4bb99c043bae42e73d

Sex and strain dependent differences in mucosal immunology and microbiota composition in mice

Autor: Clara Belzer, Mark V. Boekschoten, Marlies Elderman, Adriaan A. van Beek, Floor Hugenholtz, Marijke M. Faas, Bart J. de Haan, Huub F. J. Savelkoul, Paul de Vos

Publikováno v: Biology of Sex Differences 9 (2018)
Biology of Sex Differences, 9(26):26. BioMed Central Ltd.
Biology of Sex Differences, Vol 9, Iss 1, Pp 1-18 (2018)
Biology of Sex Differences
Biology of Sex Differences, 9

Background A dysbiosis in the intestinal microbiome plays a role in the pathogenesis of several immunological diseases. These diseases often show a sex bias, suggesting sex differences in immune responses and in the intestinal microbiome. We hypothes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7752802d3baa459482802d7bfa3bde47
https://doi.org/10.1186/s13293-018-0186-6

The effect of age on the intestinal mucus thickness, microbiota composition and immunity in relation to sex in mice

Autor: Bruno Sovran, Jerry M. Wells, Floor Hugenholtz, Paul de Vos, Eva Houtsma, Marlies Elderman, Katrine Graversen, Marijke M. Faas, Myrte Huijskes, Jan Dekker, Mark V. Boekschoten, Clara Belzer

Publikováno v: PLoS ONE, 12(9):e0184274. PUBLIC LIBRARY SCIENCE
PLoS ONE
PLoS ONE 12 (2017) 9
PLoS ONE, 12(9)
PLoS ONE, Vol 12, Iss 9, p e0184274 (2017)

A mucus layer covers and protects the intestinal epithelial cells from direct contact with microbes. This mucus layer not only prevents inflammation but also plays an essential role in microbiota colonization, indicating the complex interplay between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1888fbd2ea5c1b11cbbf1c5d8093f005
https://research.rug.nl/en/publications/69bd94a9-0bbc-4af4-8ead-2a710313941d