Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Marlies De Boeck"'
Autor:
Guang Chen, Geert Mannens, Marlies De Boeck, Ella J. Daly, Carla M. Canuso, Greet Teuns, Husseini Manji, Wayne C. Drevets
Publikováno v:
Molecular psychiatry
Ketamine, a racemic mixture of (S)-ketamine and (R)-ketamine enantiomers, has been used as an anesthetic, analgesic and more recently, as an antidepressant. However, ketamine has known abuse liability (the tendency of a drug to be used in non-medical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc8a419842c278132228c4723d645f2
https://pubmed.ncbi.nlm.nih.gov/33859356
https://pubmed.ncbi.nlm.nih.gov/33859356
Autor:
Marlies De Boeck, Dan D. Levy, Marie Vasquez, Kamala Pant, Patricia A. Escobar, Andrew Collins, Günter Speit, Peter Kasper, Carol Beevers, Yoshifumi Uno, Hajime Kojima, Stefan Pfuhler, Jin Tanaka, Ulla Plappert-Helbig, Sachiko Kitamoto, Brian Burlinson
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 783:6-12
As a part of the 6th IWGT, an expert working group on the comet assay evaluated critical topics related to the use of the in vivo comet assay in regulatory genotoxicity testing. The areas covered were: identification of the domain of applicability an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781cad0b98ba90c29d7ebab9efd742bf
https://doi.org/10.1016/j.mrgentox.2014.09.006
https://doi.org/10.1016/j.mrgentox.2014.09.006
Autor:
Marlies De Boeck, Svetlana L. Avlasevich, Azeddine Elhajouji, Freddy Van Goethem, Matthew Tate, Kris Van Dijck, Jeffrey C. Bemis, Frédéric Saad, Richard M. Walmsley, Steven M. Bryce, Magdalena Lukamowicz-Rajska, Stephen D. Dertinger
Publikováno v:
Environmental and Molecular Mutagenesis. 54:180-194
An automated approach for scoring in vitro micronuclei (MN) has been described in which flow cytometric analysis is combined with compound exposure, processing, and sampling in a single 96-well plate (Bryce SM et al. [2010]: Mutat Res 703:191-199). T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48ec5d06666b8cdfafff1e3a512142e7
https://doi.org/10.1002/em.21760
https://doi.org/10.1002/em.21760
Autor:
Svetlana L. Avlasevich, Stephen D. Dertinger, Anthony M. Lynch, Azeddine Elhajouji, Steven M. Bryce, Marlies De Boeck, John Nicolette, Freddy Van Goethem, Jing Shi
Publikováno v:
Mutagenesis. 26:147-152
The relative simplicity of the in vitro micronucleus (MNvit) endpoint has made it amenable to several automated scoring approaches. Flow cytometry is one such scoring platform that has been successfully employed. This review describes the origins of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efd7275f820fe75ac97ea3a9d3c7de9
https://doi.org/10.1093/mutage/geq058
https://doi.org/10.1093/mutage/geq058
Autor:
Richard D. Storer, Andreas Rothfuss, Satin Sawant, Ulla Plappert-Helbig, Sheila M. Galloway, Shuichi Hamada, Jonathan Howe, Kazuhiko Saigo, Andreas Czich, Dominique Brault, Andrew R. Kraynak, Michael R. O’Donovan, Bas-jan van der Leede, Melanie Struwe, Makoto Hayashi, Véronique Thybaud, Madoka Nakajima, Marlies De Boeck, Esther Vock, Laura Custer, Catherine C. Priestley, Jing Shi
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 702:40-69
A collaborative trial was conducted to evaluate the possibility of integrating the rat-liver Comet assay into repeat-dose toxicity studies. Fourteen laboratories from Europe, Japan and the USA tested fifteen chemicals. Two chemicals had been previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082e1a5863fbd061dff572fe450b2cad
https://doi.org/10.1016/j.mrgentox.2010.07.006
https://doi.org/10.1016/j.mrgentox.2010.07.006
Autor:
Jan van Benthem, David Jacobson-Kram, Véronique Thybaud, Masamitsu Honma, Rosalie K. Elespuru, Richard M. Walmsley, Jiri Aubrecht, Russell T. Naven, Stephen D. Dertinger, Paul D. White, George R. Douglas, Jennifer C. Sasaki, Marilyn J. Aardema, R. Daniel Benz, Albert J. Fornace, Marlies De Boeck, Patricia A. Escobar, Anthony M. Lynch, Eiji Yamamura, Robert H. Schiestl, James H. Kim, James F. Rusling
Publikováno v:
Environmental and Molecular Mutagenesis. 52:205-223
The International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) Project Committee on the Relevance and Follow-up of Positive Results in In Vitro Genetic Toxicity (IVGT) Testing established an Emerging Technologies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b881580e5ed072abe6e0faea67f8c4
https://doi.org/10.1002/em.20614
https://doi.org/10.1002/em.20614
Autor:
Yoshifumi Uno, Hajime Kojima, Takashi Omori, Raffaella Corvi, Masamistu Honma, Leonard M. Schechtman, Raymond R. Tice, Carol Beevers, Marlies De Boeck, Brian Burlinson, Cheryl A. Hobbs, Sachiko Kitamoto, Andrew R. Kraynak, James McNamee, Yuzuki Nakagawa, Kamala Pant, Ulla Plappert-Helbig, Catherine Priestley, Hironao Takasawa, Kunio Wada, Uta Wirnitzer, Norihide Asano, Patricia A. Escobar, David Lovell, Takeshi Morita, Madoka Nakajima, Yasuo Ohno, Makoto Hayashi
Publikováno v:
Mutation research. Genetic toxicology and environmental mutagenesis.
The in vivo rodent alkaline comet assay (comet assay) is used internationally to investigate the in vivo genotoxic potential of test chemicals. This assay, however, has not previously been formally validated. The Japanese Center for the Validation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51aa1acac2989944c6af4f1e0c5112b2
https://pubmed.ncbi.nlm.nih.gov/26212295
https://pubmed.ncbi.nlm.nih.gov/26212295
Autor:
Marlies De Boeck, Jacky Van Gompel, Bas-jan van der Leede, Kathleen De Vlieger, An Vynckier, Helena Geys
Publikováno v:
Mutation research. Genetic toxicology and environmental mutagenesis.
As part of the Japanese Center for the Validation of Alternative Methods (JaCVAM)-initiated international validation study of in vivo rat alkaline comet assay (comet assay), p-phenylenediamine dihydrochloride (PPD), o-phenylphenol sodium salt (OPP),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743426b873a904a6f9ebc44a6d91c24a
https://pubmed.ncbi.nlm.nih.gov/26212306
https://pubmed.ncbi.nlm.nih.gov/26212306
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 533:135-152
The purpose of this review is to summarise the data concerning genotoxicity and carcinogenicity of Co and Sb. Both metals have multiple industrial and/or therapeutical applications, depending on the considered species. Cobalt is used for the producti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917808e0d3bdba23f5c6ecf1068829c0
https://doi.org/10.1016/j.mrfmmm.2003.07.012
https://doi.org/10.1016/j.mrfmmm.2003.07.012
Publikováno v:
Journal of biopharmaceutical statistics. 23(3)
This paper proposes a flexible modeling approach for so-called comet assay data regularly encountered in pre-clinical research. While such data consist of non-Gaussian outcomes in a multi-level hierarchical structure, traditional analyses typically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9e744cfdaae4296f6b1dbdae890a7b
https://pubmed.ncbi.nlm.nih.gov/23611199
https://pubmed.ncbi.nlm.nih.gov/23611199