Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Marlies Ballegeer"'
Autor:
Marlies Ballegeer, Revina C. van Scherpenzeel, Teresa Delgado, Maria Iglesias-Caballero, Blanca García Barreno, Shubham Pandey, Scott A. Rush, Joost A. Kolkman, Vicente Mas, Jason S. McLellan, Xavier Saelens
Publikováno v:
mBio, Vol 15, Iss 1 (2024)
ABSTRACTHuman metapneumovirus (hMPV) is a leading cause of viral lower respiratory tract disease in children and adults. The hMPV fusion protein F is a trimeric class I fusion protein that is initially synthesized as a precursor (F0) and requires pro
Externí odkaz:
https://doaj.org/article/330be15de3c94cdfbbfe809b80487fea
Autor:
Bram Van Den Eeckhout, Marlies Ballegeer, Jozefien De Clercq, Elianne Burg, Xavier Saelens, Linos Vandekerckhove, Sarah Gerlo
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15770 (2023)
IL-1R integrates signals from IL-1α and IL-1β, and it is widely expressed across tissues and immune cell types. While the expression pattern and function of IL-1R within the innate immune system is well studied, its role in adaptive immunity, parti
Externí odkaz:
https://doaj.org/article/156ce21a434b42feb713b538afc44d85
Autor:
Lien Van Hoecke, Kenny Roose, Marlies Ballegeer, Zifu Zhong, Niek N. Sanders, Stefaan De Koker, Xavier Saelens, Sandra Van Lint
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 22, Iss , Pp 373-381 (2020)
mRNA-lipoplex vaccines are currently being explored in phase II clinical trials for the treatment of patients with advanced solid tumors. Mechanistically, these mRNA-lipoplex vaccines are characterized by the induction of type I interferon (IFN) cent
Externí odkaz:
https://doaj.org/article/0d322f9a8baa46c59fd0f61a81777a2c
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Neuraminidase of influenza A and B viruses plays a critical role in the virus life cycle and is an important target of the host immune system. Here, we highlight the current understanding of influenza neuraminidase structure, function, antigenicity,
Externí odkaz:
https://doaj.org/article/5b8625be21af4b1bbc0ead13de31527f
Autor:
Silvie Van den Hoecke, Marlies Ballegeer, Bram Vrancken, Lei Deng, Emma R. Job, Kenny Roose, Bert Schepens, Lien Van Hoecke, Philippe Lemey, Xavier Saelens
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT The ectodomain of matrix protein 2 (M2e) of influenza A viruses is a universal influenza A vaccine candidate. Here, we report potential evasion strategies of influenza A viruses under in vivo passive anti-M2e IgG immune selection pressure in
Externí odkaz:
https://doaj.org/article/d51386aa0cb244889e4bdf58c40d32b6
Autor:
Jolien Souffriau, Steven Timmermans, Tineke Vanderhaeghen, Charlotte Wallaeys, Kelly Van Looveren, Lindsy Aelbrecht, Sylviane Dewaele, Jolien Vandewalle, Evy Goossens, Serge Verbanck, Filip Boyen, Melanie Eggermont, Lindsey De Commer, Riet De Rycke, Michiel De Bruyne, Raul Tito, Marlies Ballegeer, Sofie Vandevyver, Tiago Velho, Luis Ferreira Moita, Tino Hochepied, Karolien De Bosscher, Jeroen Raes, Filip Van Immerseel, Rudi Beyaert, Claude Libert
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 10, Pp n/a-n/a (2020)
Abstract The cytokine TNF drives inflammatory diseases, e.g., Crohn's disease. In a mouse model of TNF‐induced systemic inflammatory response syndrome (SIRS), severe impact on intestinal epithelial cells (IECs) is observed. Zinc confers complete pr
Externí odkaz:
https://doaj.org/article/3e993b5bbeaf4e78b2bc46c529806814
Autor:
Dorien De Vlieger, Katja Hoffmann, Inge Van Molle, Wim Nerinckx, Lien Van Hoecke, Marlies Ballegeer, Sarah Creytens, Han Remaut, Hartmut Hengel, Bert Schepens, Xavier Saelens
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Lower respiratory tract infections, such as infections caused by influenza A viruses, are a constant threat for public health. Antivirals are indispensable to control disease caused by epidemic as well as pandemic influenza A. We developed a novel an
Externí odkaz:
https://doaj.org/article/904c593ec4bb4ae0b94a9ee3f1f2d0f0
Autor:
Ioanna Petta, Nadia Bougarne, Jolien Vandewalle, Lien Dejager, Sofie Vandevyver, Marlies Ballegeer, Sofie Desmet, Jonathan Thommis, Lode De Cauwer, Sam Lievens, Claude Libert, Jan Tavernier, Karolien De Bosscher
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract The transcriptional activity of the glucocorticoid receptor (GR) is co-determined by its ability to recruit a vast and varying number of cofactors. We here identify Striatin-3 (STRN3) as a novel interaction partner of GR that interferes with
Externí odkaz:
https://doaj.org/article/77db01aba2e84ce3beeed9e7bccc5c85
Publikováno v:
Biomolecules, Vol 10, Iss 12, p 1663 (2020)
Sera of camelid species contain a special kind of antibody that consists only of heavy chains. The variable antigen binding domain of these heavy chain antibodies can be expressed as a separate entity, called a single domain antibody that is characte
Externí odkaz:
https://doaj.org/article/c0903a0535cb4ce78670962e69428b54
Autor:
Marlies Ballegeer, Xavier Saelens
Publikováno v:
Viruses, Vol 12, Iss 5, p 542 (2020)
Viruses are the most common cause of acute respiratory tract infections (ARTI). Human metapneumovirus (hMPV) frequently causes viral pneumonia which can become life-threatening if the virus spreads to the lungs. Even though hMPV was only isolated in
Externí odkaz:
https://doaj.org/article/e662c1e449da4e6ab8f97d4f1858f329