Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Marlieke L.M. Jongsma"'
Autor:
Antonius A. de Waard, Tamara Verkerk, Kelly Hoefakker, Dirk M. van der Steen, Marlieke L.M. Jongsma, Dganit Melamed Kadosh, Sophie Bliss, Arnoud H. de Ru, Arie Admon, Peter A. van Veelen, Marieke Griffioen, Mirjam H.M. Heemskerk, Robbert M. Spaapen
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102051- (2021)
Summary: Tumors with an impaired transporter associated with antigen processing (TAP) present several endoplasmic reticulum-derived self-antigens on HLA class I (HLA-I) which are absent on healthy cells. Selection of such TAP-independent antigens for
Externí odkaz:
https://doaj.org/article/7c59367dd0bf44f2a0d7bcc40600996c
Autor:
Robbert M. Spaapen, Marieke Griffioen, Tuna Mutis, J.H. Frederik Falkenburg, Henk M. Lokhorst, Marlieke L.M. Jongsma, Sophie Bliss, Maria W. Honders, Edith D. van der Meijden, Cornelis A.M. van Bergen, Rimke Oostvogels, Margot J. Pont
Supplementary Figure 2. The generation of the LB-TTK-1D peptide is proteasome-dependent. LB-TTK-1D antigen positive EBV-LCLs were treated with increasing concentrations of the proteasome inhibitor bortezomib for 48h, washed and exposed to LB-TTK-1D-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21888529c5609c43ec8d4e3a391fa97
https://doi.org/10.1158/2326-6066.22535887.v1
https://doi.org/10.1158/2326-6066.22535887.v1
Autor:
Robbert M. Spaapen, Marieke Griffioen, Tuna Mutis, J.H. Frederik Falkenburg, Henk M. Lokhorst, Marlieke L.M. Jongsma, Sophie Bliss, Maria W. Honders, Edith D. van der Meijden, Cornelis A.M. van Bergen, Rimke Oostvogels, Margot J. Pont
MHC-bound peptides from aberrant proteins may be a specific immunotherapeutic target on cancer cells. Because of difficulties in identifying such antigens, viral or model antigens have so far been used to study their biological relevance. We here ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5379cfe3a4e0f647c8b4d277c2e5d13
https://doi.org/10.1158/2326-6066.c.6547975.v1
https://doi.org/10.1158/2326-6066.c.6547975.v1
Autor:
Robbert M. Spaapen, Marieke Griffioen, Tuna Mutis, J.H. Frederik Falkenburg, Henk M. Lokhorst, Marlieke L.M. Jongsma, Sophie Bliss, Maria W. Honders, Edith D. van der Meijden, Cornelis A.M. van Bergen, Rimke Oostvogels, Margot J. Pont
Supplementary Figure 1. The LB-TTK-1D-specific (clone 10-5) and USP11-specific T cell clones have a similar affinity for their cognate peptide. Synthetic peptides RLHDGRVFV (peptideTTK) or FTWEGLYNV (peptideUSP11) were loaded on T2 cells in a serial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1406d36a105b379d6ca2cfada692bed3
https://doi.org/10.1158/2326-6066.22535890
https://doi.org/10.1158/2326-6066.22535890
Autor:
Sabina Y. van der Zanden, Marlieke L.M. Jongsma, Anna C.M. Neefjes, Ilana Berlin, Jacques Neefjes
Publikováno v:
Trends Cell Biol
Trends in Cell Biology, 33(1), 18-29. ELSEVIER SCIENCE LONDON
Trends in Cell Biology, 33(1), 18-29. ELSEVIER SCIENCE LONDON
The nuclear envelope (NE) is central to the architecture of eukaryotic cells, both as a physical barrier separating the nucleus from the cytoplasm and as gate-keeper of selective transport between them. However, in open mitosis, the NE fragments to a
Autor:
Robbert M. Spaapen, Marieke Griffioen, Peter A. van Veelen, Sophie Bliss, Arie Admon, Tamara Verkerk, Antonius A. de Waard, Dirk M. van der Steen, Dganit Melamed Kadosh, Arnoud H. de Ru, Kelly Hoefakker, Mirjam H.M. Heemskerk, Marlieke L.M. Jongsma
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102051-(2021)
iScience, 24(2). Elsevier Inc.
iScience, 24(2). CELL PRESS
iScience
iScience, 24(2). Elsevier Inc.
iScience, 24(2). CELL PRESS
iScience
Summary Tumors with an impaired transporter associated with antigen processing (TAP) present several endoplasmic reticulum-derived self-antigens on HLA class I (HLA-I) which are absent on healthy cells. Selection of such TAP-independent antigens for
Autor:
Xiangrui Kong, Robbert M. Spaapen, Arnoud H. de Ru, George M.C. Janssen, Sunesh Sethumadhavan, Tamara Verkerk, Frans H.J. Claas, Robert Tampé, Carolin Gerke, Peter A. van Veelen, Marlieke L.M. Jongsma, Arend Mulder, Kelly Hoefakker, Sophie Bliss, Antonius A. de Waard, Anne Halenius
Publikováno v:
European Journal of Immunology
European journal of immunology, 51(3), 734-737. Wiley-VCH Verlag
European journal of immunology, 51(3), 734-737. Wiley-VCH Verlag
A single model system for integrative studies on multiple facets of antigen presentation is lacking. PAKC is a novel panel of ten cell lines knocked out for individual components of the HLA class I antigen presentation pathway. PAKC will accelerate H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::880caccc7d42858052d3d8a15cc9192c
https://hdl.handle.net/1887/3243135
https://hdl.handle.net/1887/3243135
Autor:
Douglas E. Kline, Robbert M. Spaapen, Sravya Tumuluru, Xiufen Chen, Darshan N. Kasal, James Godfrey, Brendan W. MacNabb, Jovian Yu, Marlieke L.M. Jongsma, Justin Kline
Publikováno v:
SSRN Electronic Journal.
Antigen cross-presentation, wherein dendritic cells (DC) present exogenous antigen on MHC-I molecules, is considered the primary mechanism by which DCs initiate tumor-specific CD8+ T cell responses. Here, we demonstrate that MHC-dressing, an antigen
Autor:
Jacques Neefjes, Anastasia Xagara, Johannes B. Huppa, Matthijs Raaben, Sophie Bliss, Xiangrui Kong, Elmer Stickel, Mirjam H.M. Heemskerk, Tao Zhang, Hermen S. Overkleeft, Stephanie Holst, Soldano Ferrone, Birol Cabukusta, Vincent A. Blomen, Manfred Wuhrer, Thijn R. Brummelkamp, Antonius A. de Waard, Carolin Gerke, Anne Halenius, René Platzer, Lennert Janssen, Rosina Plomp, Marlieke L.M. Jongsma, Arend Mulder, Tamara Verkerk, Frans H.J. Claas, Marieke Griffioen, Robbert M. Spaapen
Publikováno v:
Immunity
Immunity, 54(1), 132-150.e9. Cell Press
Immunity, 54(1), 132-150.e9. CELL PRESS
Immunity, 54(1), 132-150.e9. Cell Press
Immunity, 54(1), 132-150.e9. CELL PRESS
HLA class I (HLA-I) glycoproteins drive immune responses by presenting antigens to cognate CD8+ T cells. This process is often hijacked by tumors and pathogens for immune evasion. Because options for restoring HLA-I antigen presentation are limited,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc52593816d0dbe9f26a66bfd1bf047
https://europepmc.org/articles/PMC8722104/
https://europepmc.org/articles/PMC8722104/
Autor:
Tom Cremer, Alfred C.O. Vertegaal, Marlieke L.M. Jongsma, Fredrik Trulsson, Jacques Neefjes, Ilana Berlin
The endolysosomal system fulfills a wide variety of cellular functions, many of which are modulated through interactions with other organelles. In particular, the ER exerts spatiotemporal constraints on the organization and motility of endosomes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eee5a6907d1add3b4166838470f422e
https://zenodo.org/record/4327610
https://zenodo.org/record/4327610