Výsledky vyhledávání - "Marlieke L. M. Jongsma"

Akademický článek

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export

Autor: Dick J. H. van den Boomen, Agata Sienkiewicz, Ilana Berlin, Marlieke L. M. Jongsma, Daphne M. van Elsland, J. Paul Luzio, Jacques J. C. Neefjes, Paul J. Lehner

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)

Lysosomes play an important role in cellular LDL-cholesterol uptake. Here, the authors perform a genome-wide genetic screen for cholesterol regulators and identify C18orf8 as a conserved subunit of a trimeric Rab7 GEF that controls LDL trafficking an

Externí odkaz: https://doaj.org/article/5ea86788f5ff452193f198cb9ba6bdd4

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Choreographing the motor-driven endosomal dance

Autor: Marlieke L. M. Jongsma, Nina Bakker, Jacques Neefjes

Publikováno v: Journal of Cell Science. 136

The endosomal system orchestrates the transport of lipids, proteins and nutrients across the entire cell. Along their journey, endosomes mature, change shape via fusion and fission, and communicate with other organelles. This intriguing endosomal cho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20fd3ebd517946ae231aca18c5ee5123
https://doi.org/10.1242/jcs.259689

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Assaying peptide translocation by the peptide transporter TAP

Autor: Marlieke L M, Jongsma, Jacques, Neefjes

Publikováno v: Methods in molecular biology (Clifton, N.J.). 960

MHC class I molecules display peptides at the cell surface that are mostly derived from cytosolic or nuclear proteins. Since peptide loading of MHC class I molecules occurs in the ER lumen, cytosolic peptides have to pass the ER membrane. The peptide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5b74e4325d6f0f0431af73b460a03d73
https://pubmed.ncbi.nlm.nih.gov/23329478

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