Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Marli E. Ebus"'
Autor:
Thomas F. Eleveld, Lindy Vernooij, Linda Schild, Bianca Koopmans, Lindy K. Alles, Marli E. Ebus, Rana Dandis, Harm van Tinteren, Huib N. Caron, Jan Koster, Max M. van Noesel, Godelieve A. M. Tytgat, Selma Eising, Rogier Versteeg, M. Emmy M. Dolman, Jan J. Molenaar
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionMutations affecting the RAS-MAPK pathway occur frequently in relapsed neuroblastoma tumors and are associated with response to MEK inhibition in vitro. However, these inhibitors alone do not lead to tumor regression in vivo, indicating th
Externí odkaz:
https://doaj.org/article/f113f91a5d74419a8ac27a8cd36776b9
Autor:
Jan J. Molenaar, Rogier Versteeg, Peter van Sluis, Godelieve A. Tijtgat, Richard Volckmann, Marli E. Ebus, Lindy K. Alles, Danny A. Zwijnenburg, Jan Koster, Linda Schild, Thomas F. Eleveld
Supplementary Figure 1: RAS-MAPK activation on the protein level is related to mutation status, Supplementary Figure 2: Differentially expressed genes between the experimental systems used for signature generation, Supplementary Figure 3: Differences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e718a10555b73e881a86011be4e3361
https://doi.org/10.1158/0008-5472.22419947
https://doi.org/10.1158/0008-5472.22419947
Autor:
Jan J. Molenaar, Rogier Versteeg, Peter van Sluis, Godelieve A. Tijtgat, Richard Volckmann, Marli E. Ebus, Lindy K. Alles, Danny A. Zwijnenburg, Jan Koster, Linda Schild, Thomas F. Eleveld
Mutations affecting the RAS–MAPK pathway frequently occur in relapsed neuroblastoma tumors, which suggests that activation of this pathway is associated with a more aggressive phenotype. To explore this hypothesis, we generated several model system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf93e63bcd3155267314d8a3b712bd87
https://doi.org/10.1158/0008-5472.c.6510512.v1
https://doi.org/10.1158/0008-5472.c.6510512.v1
Autor:
Jan J. Molenaar, Louis Chesler, Huib N. Caron, Rogier Versteeg, Robbert J. Kok, Rolf W. Sparidans, Kevin Petrie, Simon P. Robinson, Albert Hallsworth, Yann Jamin, Carel J.M. van Noesel, Ilona J.M. den Hartog, Marli E. Ebus, Evon Poon, M. Emmy M. Dolman
Supplementary Tables S1-3. Table S1. IC25/50/75 and LC50 values of AT7519 for MYCN-amplified and non-MYCN-amplified neuroblastoma cell lines and cell seeding densities used to perform MTT cell proliferation assays (96-well plates). IC25/50/75 and LC5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ebcc78bfc11a54290daef6f42738a0
https://doi.org/10.1158/1078-0432.22454805
https://doi.org/10.1158/1078-0432.22454805
Autor:
Jan J. Molenaar, Louis Chesler, Huib N. Caron, Rogier Versteeg, Robbert J. Kok, Rolf W. Sparidans, Kevin Petrie, Simon P. Robinson, Albert Hallsworth, Yann Jamin, Carel J.M. van Noesel, Ilona J.M. den Hartog, Marli E. Ebus, Evon Poon, M. Emmy M. Dolman
Purpose: MYCN-dependent neuroblastomas have low cure rates with current multimodal treatment regimens and novel therapeutic drugs are therefore urgently needed. In previous preclinical studies, we have shown that targeted inhibition of cyclin-depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3cc7892d78b44f7f43dd133ff375f8
https://doi.org/10.1158/1078-0432.c.6522837.v1
https://doi.org/10.1158/1078-0432.c.6522837.v1
Autor:
Jan J. Molenaar, Louis Chesler, Huib N. Caron, Rogier Versteeg, Robbert J. Kok, Rolf W. Sparidans, Kevin Petrie, Simon P. Robinson, Albert Hallsworth, Yann Jamin, Carel J.M. van Noesel, Ilona J.M. den Hartog, Marli E. Ebus, Evon Poon, M. Emmy M. Dolman
Supplementary Materials and Methods. Detailed protocol for cell culturing, in vitro and in vivo Western Blotting, in vitro FACS analysis, in vitro synergy studies and in vivo immunohistochemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd734fbdfced6b5caa6131627babed4
https://doi.org/10.1158/1078-0432.22454808
https://doi.org/10.1158/1078-0432.22454808
Autor:
Jan J. Molenaar, Rogier Versteeg, Peter van Sluis, Godelieve A. Tijtgat, Richard Volckmann, Marli E. Ebus, Lindy K. Alles, Danny A. Zwijnenburg, Jan Koster, Linda Schild, Thomas F. Eleveld
Supplementary Table 1: Public datasets used in this study, Supplementary Table 2: gRNA sequences against CIC, NF1 and DMD, Supplementary Table 3: Primers used for RT-qPCR experiments, Supplementary Table 4: Genes differentially expressed in the vario
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2902dbfd3ed8764d32c6a2e651870f
https://doi.org/10.1158/0008-5472.22419944.v1
https://doi.org/10.1158/0008-5472.22419944.v1
Autor:
Jan J. Molenaar, Louis Chesler, Huib N. Caron, Rogier Versteeg, Robbert J. Kok, Rolf W. Sparidans, Kevin Petrie, Simon P. Robinson, Albert Hallsworth, Yann Jamin, Carel J.M. van Noesel, Ilona J.M. den Hartog, Marli E. Ebus, Evon Poon, M. Emmy M. Dolman
Supplementary figures S1-8. Fig. S1. Sensitivity of neuroblastoma cells to AT7519 is partially dependent on MYCN amplification status. Fig. S2. AT7519 more potently induces PARP cleavage in MYCN-amplified neuroblastoma cells. Fig. S3. FACS plots show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423265fb51fd901d839d835c54768647
https://doi.org/10.1158/1078-0432.22454799.v1
https://doi.org/10.1158/1078-0432.22454799.v1
Autor:
Jan J. Molenaar, Louis Chesler, Huib N. Caron, Rogier Versteeg, Robbert J. Kok, Rolf W. Sparidans, Kevin Petrie, Simon P. Robinson, Albert Hallsworth, Yann Jamin, Carel J.M. van Noesel, Ilona J.M. den Hartog, Marli E. Ebus, Evon Poon, M. Emmy M. Dolman
Legends for supplementary figures S1-S8.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164ae6e54525d419e2ea8febad561764
https://doi.org/10.1158/1078-0432.22454811
https://doi.org/10.1158/1078-0432.22454811
Autor:
Thomas F. Eleveld, Lindy Vernooij, Linda Schild, Bianca Koopmans, Lindy K. Alles, Marli E. Ebus, Rana Dandis, Harm van Tinteren, Huib N. Caron, Jan Koster, Max M. van Noesel, Godelieve A. M. Tytgat, Selma Eising, Rogier Versteeg, M. Emmy M. Dolman, Jan J. Molenaar
Publikováno v:
SSRN Electronic Journal.
IntroductionMutations affecting the RAS-MAPK pathway occur frequently in relapsed neuroblastoma tumors and are associated with response to MEK inhibition in vitro. However, these inhibitors alone do not lead to tumor regression in vivo, indicating th