Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Marley Aparecida Licínio"'
1
Akademický článek
Analysis of the presence of FLT3 gene mutation and association with prognostic factors in adult and pediatric acute leukemia patients
Autor: Graciele Burnatt, Marley Aparecida Licínio, Pâmela Cristina Gaspar, Arthur Schveitzer Ferreira, Manoela Lira Reis, Ana Carolina Rabello de Moraes, Thaís Cristine Marques Sincero, Maria Cláudia Santos-Silva
Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Vol 53, Iss 2 (2017)
ABSTRACT When the FLT3 gene is mutated, it originates a modified receptor with structural changes, which give survival advantage and malignant hematopoietic cell proliferation. Thus, the presence of mutations in this gene is considered an unfavorable
Externí odkaz: https://doaj.org/article/5aa2aa305f1a446683ed8df70d112ea2
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2
Akademický článek
Importância da detecção das mutações no gene FLT3 e no gene NPM1 na leucemia mieloide aguda - Classificação da Organização Mundial de Saúde 2008 Importance of detecting FLT3 and NPM1 gene mutations in acute myeloid leukemia -World Health Organization Classification 2008
Autor: Marley Aparecida Licínio, Maria Cláudia Santos da Silva
Publikováno v: Revista Brasileira de Hematologia e Hemoterapia, Vol 32, Iss 6, Pp 476-481 (2010)
As leucemias mieloides agudas (LMA) constituem um grupo de neoplasias malignas caracterizadas pela proliferação descontrolada de células hematopoéticas, decorrente de mutações que podem ocorrer em diferentes fases da diferenciação de células
Externí odkaz: https://doaj.org/article/8655b3c1b35c4d77a7eda0811fd9371d
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3
Analysis of the presence of FLT3 gene mutation and association with prognostic factors in adult and pediatric acute leukemia patients
Autor: Marley Aparecida Licínio, Maria Cláudia Santos-Silva, Arthur Schveitzer Ferreira, Thaís Cristine Marques Sincero, Ana Carolina Rabello de Moraes, Manoela Lira Reis, Pâmela Cristina Gaspar, Graciele Burnatt
Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Vol 53, Iss 2 (2017)
Brazilian Journal of Pharmaceutical Sciences, Volume: 53, Issue: 2, Article number: e16105, Published: 22 JUN 2017
Brazilian Journal of Pharmaceutical Sciences; Vol. 53 No. 2 (2017); e16105
Brazilian Journal of Pharmaceutical Sciences; Vol. 53 Núm. 2 (2017); e16105
Brazilian Journal of Pharmaceutical Sciences; v. 53 n. 2 (2017); e16105
Brazilian Journal of Pharmaceutical Sciences
Universidade de São Paulo (USP)
instacron:USP
When the FLT3 gene is mutated, it originates a modified receptor with structural changes, which give survival advantage and malignant hematopoietic cell proliferation. Thus, the presence of mutations in this gene is considered an unfavorable prognost
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb1c2da7dec5c1ec4a4563e6cab3e05
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200617&lng=en&tlng=en
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4
Apoptotic effect of synthetic 2′,4′,5′-trimethoxychalcones in human K562 and Jurkat leukemia cells
Autor: Marlon Norberto Sechini Cordeiro, Lorena dos Santos Bubniak, Aline Bogoni Costa, Marley Aparecida Licínio Marzarotto, Alessandra Mascarello, Taisa Regina Stumpf, Ana Carolina Rabello de Moraes, Ricardo José Nunes, Rosendo A. Yunes, Maria Cláudia Santos-Silva, Louise Domeneghini Chiaradia-Delatorre
Publikováno v: Medicinal Chemistry Research. 23:4301-4319
In this study, we assessed the cytotoxic effect of synthetic 2′,4′,5′-trimethoxychalcones on the human K562 acute myeloid leukemia cell and human Jurkat acute lymphoid leukemia cell. Compounds 13, 16, 19, and 26 showed low IC50 values (4.10–8
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d6e307f4b6ad1c46d543bb3e05e61e1
https://doi.org/10.1007/s00044-014-1002-4
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5
Apoptotic events induced by synthetic naphthylchalcones in human acute leukemia cell lines
Autor: Rosendo A. Yunes, Ricardo José Nunes, Maria Cláudia Santos-Silva, Marley Aparecida Licínio, Ana Carolina Rabello de Moraes, Mariana Franzoni Maioral, Pâmela Cristina Gaspar, Alessandra Mascarello, Louise Domeneghini Chiaradia, Gabriela Regina Rosa Souza
Publikováno v: Biochimie. 95(4):866-874
Acute leukemia is a disorder of the hematopoietic system characterized by the expansion of a clonal population of cells blocked from differentiating into mature cells. Recent studies have shown that chalcones and their derivatives induce apoptosis in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08bb9120c72b11af0c1898d7d552336
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6
Evaluation of multidrug resistance in 46 newly diagnosed patients with acute leukemia
Autor: Marley Aparecida Licínio, Maria Luiza Bazzo, Maria Cláudia Santos da Silva, Júlio Araújo Zampirolo, Ana Carolina Rabello de Moraes, Susie Coutinho Liedke, Joanita Ângela Gonzaga Del Moral, Marcos José Machado
Publikováno v: Hematology. 17:59-65
ObjectivesThe aim of the present study was to assess the expression profile of multidrug resistance (MDR)-related proteins ABCB1, ABCC1 and LRP in 46 patients with acute leukemia (AL).MethodsThe levels of MDR gene mRNA expression and protein expressi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32030b095b3207ad08eee3d949a780d
https://doi.org/10.1179/102453312x13221316477570
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7
Evaluation of apoptotic effect of cyclic imide derivatives on murine B16F10 melanoma cells
Autor: Lorena Santos-Bubniak, Marley Aparecida Licínio, Maria Cláudia Santos-Silva, Kely Navakoski de Oliveira, Karina Elisa Machado, Ricardo José Nunes
Publikováno v: Bioorganic & Medicinal Chemistry. 19:6285-6291
Cyclic imides are a large class of compounds obtained by organic synthesis including several sub-classes (succinimides maleimide, glutarimide, phthalimides naphtalimides, and its derivatives). Recently, some cyclic imide derivatives have shown import
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0125931b024d963b34dd0f6e072cbb
https://doi.org/10.1016/j.bmc.2011.09.008
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10
Ester derivatives of gallic acid with potential toxicity toward L1210 leukemia cells
Autor: Paulo César Leal, Camila A de Souza, Rosendo A. Yunes, Maria Luiza Bazzo, Maria Cláudia Santos-Silva, Rober Rosso, Marley Aparecida Licínio, Claudriana Locatelli, Tânia Beatriz Creczynski-Pasa
Publikováno v: Bioorganic & Medicinal Chemistry. 16:3791-3799
Gallic acid and gallates with the same number of hydroxyl groups and varying the length of the side carbon chain, with respective lipophilicity being defined through the ClogP values, were examined for their ability to induce apoptosis (through the D
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5120fa51a5ab7c4111bac71cab1a9cb3
https://doi.org/10.1016/j.bmc.2008.01.049
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