Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Marlene Thorsen Mørch"'
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-8 (2018)
Abstract Background Encounter of autoantibodies with specific antigens can lead to hypersensitivity reactions and pathology. In multiple sclerosis and neuromyelitis optica spectrum disease (NMOSD), immunoglobulin-G (IgG) deposition has been observed
Externí odkaz:
https://doaj.org/article/5f7b1898829d46a788b28b64e692bd5c
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
Immune-mediated tissue damage or hypersensitivity can be mediated by autospecific IgG antibodies. Pathology results from activation of complement, and antibody-dependent cellular cytotoxicity (ADCC), mediated by inflammatory effector leukocytes inclu
Externí odkaz:
https://doaj.org/article/b22a6ca970e54db0a2a85593b7fb4b77
Autor:
Nasrin Asgari, Magdalena Dubik, Soeren Nors Nielsen, John Nieland, Trevor Owens, Joanna Marczynska, Reza Khorooshi, Marlene Thorsen Mørch
Publikováno v:
Morch, M T, Khorooshi, R, Marczynska, J, Dubik, M, Nielsen, S, Nieland, J D, Asgari, N & Owens, T 2021, ' Mitochondria–A target for attenuation of astrocyte pathology ', Journal of Neuroimmunology, vol. 358, 577657 . https://doi.org/10.1016/j.jneuroim.2021.577657
Astrocyte pathology is a feature of neuromyelitis optica spectrum disorder (NMOSD) pathology. Recently mitochondrial dysfunction and metabolic changes were suggested to play a role in NMOSD. To elucidate the role of mitochondrial dysfunction, astrocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc0bd98a198360851e4881d1867ee52d
https://vbn.aau.dk/ws/files/431658716/1_s2.0_S0165572821001843_main.pdf
https://vbn.aau.dk/ws/files/431658716/1_s2.0_S0165572821001843_main.pdf
Autor:
Reza Khorooshi, Marlene Thorsen Mørch, Trevor Owens, Kirstine Nolling Jensen, Agnieszka Wlodarczyk, Joanna Marczynska, Magdalena Dubik, Gill Webster
Publikováno v:
Dubik, M, Marczynska, J, Mørch, M T, Webster, G, Jensen, K N, Wlodarczyk, A, Khorooshi, R & Owens, T 2021, ' Innate Signaling in the CNS Prevents Demyelination in a Focal EAE Model ', Frontiers in Neuroscience, vol. 15, 682451 . https://doi.org/10.3389/fnins.2021.682451
Frontiers in Neuroscience, Vol 15 (2021)
Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 15 (2021)
Frontiers in Neuroscience
The pathological hallmark of multiple sclerosis (MS) is the formation of multifocal demyelinating lesions in the central nervous system (CNS). Stimulation of innate receptors has been shown to suppress experimental autoimmune encephalomyelitis (EAE),
Autor:
Anouk Benmamar-Badel, Marlene Thorsen Mørch, Gill Webster, Dina S. Arengoth, Trevor Owens, Magdalena Dubik, Reza Khorooshi, Agnieszka Wlodarczyk, Joanna Marczynska, Nasrin Asgari
Publikováno v:
Owens, T, Benmamar-Badel, A, Wlodarczyk, A, Marczynska, J, Mørch, M T, Dubik, M, Arengoth, D S, Asgari, N, Webster, G & Khorooshi, R 2020, ' Protective roles for myeloid cells in neuroinflammation ', Scandinavian Journal of Immunology, vol. 92, no. 5, e12963 . https://doi.org/10.1111/sji.12963
Myeloid cells represent the major cellular component of innate immune responses. Myeloid cells include monocytes and macrophages, granulocytes (neutrophils, basophils and eosinophils) and dendritic cells (DC). The role of myeloid cells has been broad
Publikováno v:
Mørch, M T, Forsberg Sørensen, S, Khorooshi, R M H, Asgari, N & Owens, T 2018, ' Selective localization of IgG from cerebrospinal fluid to brain parenchyma ', Journal of Neuroinflammation, vol. 15, 110 . https://doi.org/10.1186/s12974-018-1159-8
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-8 (2018)
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-8 (2018)
Journal of Neuroinflammation
Background: Encounter of autoantibodies with specific antigens can lead to hypersensitivity reactions and pathology. In multiple sclerosis and neuromyelitis optica spectrum disease (NMOSD), immunoglobulin-G (IgG) deposition has been observed in patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78387ff76750ee54d6c7aea7ded1367a
https://findresearcher.sdu.dk:8443/ws/files/139462605/Selective_localization_of_IgG.pdf
https://findresearcher.sdu.dk:8443/ws/files/139462605/Selective_localization_of_IgG.pdf
Autor:
Marlene Thorsen Mørch, Shohreh Issazadeh-Navikas, Thomas Hellesøe Holm, Dina Dræby, Siegfried Weiss, Trevor Owens, Stefan Lienenklaus, Carsten Tue Berg, Ruthe Storgaard Dieu, Reza Khorooshi
Publikováno v:
Acta Neuropathologica
Khorooshi, R, Mørch, M T, Holm, T, Berg, C T, Dieu, R T, Dræby, D, Issazadeh-Navikas, S, Weiss, S, Lienenklaus, S & Owens, T 2015, ' Induction of endogenous Type I interferon within the central nervous system plays a protective role in experimental autoimmune encephalomyelitis ', Acta Neuropathologica, vol. 130, no. 1, pp. 107-118 . https://doi.org/10.1007/s00401-015-1418-z
Khorooshi, R, Mørch, M T, Holm, T, Berg, C T, Dieu, R T, Dræby, D, Issazadeh-Navikas, S, Weiss, S, Lienenklaus, S & Owens, T 2015, ' Induction of endogenous Type I interferon within the central nervous system plays a protective role in experimental autoimmune encephalomyelitis ', Acta Neuropathologica, vol. 130, no. 1, pp. 107-118 . https://doi.org/10.1007/s00401-015-1418-z
The Type I interferons (IFN), beta (IFN-β) and the alpha family (IFN-α), act through a common receptor and have anti-inflammatory effects. IFN-β is used to treat multiple sclerosis (MS) and is effective against experimental autoimmune encephalomye
Autor:
Agnieszka Wlodarczyk, Ulrike Muscha Steckelings, Camilla Hermansen, Reza Khorooshi, Trevor Owens, Marlene Thorsen Mørch
Publikováno v:
Irish Journal of Medical Science (1971 -). 184:1-18
Publikováno v:
Annals of Clinical and Translational Neurology
Asgari, N, Berg, C T, Mørch, M T, Khorooshi, R & Owens, T 2015, ' Cerebrospinal fluid aquaporin-4-immunoglobulin G disrupts blood brain barrier ', Annals of Clinical and Translational Neurology, vol. 2, no. 8, pp. 857-63 . https://doi.org/10.1002/acn3.221
Asgari, N, Berg, C T, Mørch, M T, Khorooshi, R & Owens, T 2015, ' Cerebrospinal fluid aquaporin-4-immunoglobulin G disrupts blood brain barrier ', Annals of Clinical and Translational Neurology, vol. 2, no. 8, pp. 857-63 . https://doi.org/10.1002/acn3.221
To clarify the significance of immunoglobulin G autoantibody specific for the astrocyte water channel aquaporin-4 in cerebrospinal fluid, aquaporin-4-immunoglobulin G from a neuromyelitis optica patient was administered intrathecally to naïve mice,
Autor:
Dina Dræby, Marlene Thorsen Mørch, Carsten Tue Berg, Ruthe Storgaard Dieu, Stefan Lienenklaus, Thomas Hellesøe Holm, Reza Khorooshi, Siegfried Weiss, Trevor Owens
Publikováno v:
Journal of Neuroimmunology. 275:86-87