Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Marlene S. Strayer"'
Autor:
Jeffrey A. Kazzaz, Marlene S. Strayer, Jichuan Wu, Daniel J. Malone, Hshi-chi Koo, Thomas H. Shaffer, Jonathan M. Davis, David S. Strayer, Marla R. Wolfson
Publikováno v:
Pulmonary Medicine, Vol 2011 (2011)
We compared lung delivery methods of recombinant adenovirus (rAd): (1) rAd suspended in saline, (2) rAd suspended in saline followed by a pulse-chase of a perfluorochemical (PFC) liquid mixture, and (3) a PFC-rAd suspension. Cell uptake, distribution
Externí odkaz:
https://doaj.org/article/4f3fc23b5ca449889e77e4a27e8126e1
Autor:
Terence R. Flotte, David S. Strayer, Christian Mueller, Jeffery Sirninger, Sofia Braag, Jean-Pierre Louboutin, Francisco Branco, Marlene S. Strayer
Publikováno v:
Gene therapy
In cystic fibrosis (CF), respiratory failure caused by progressive airway obstruction and tissue damage is primarily a result of the aberrant inflammatory responses to lung infections with Pseudomonas aeruginosa. Despite considerable improvement in p
Autor:
Dimitrios Hatzis, Jonathan M. Davis, Yuchi Li, Hshi-chi Koo, Harry Opsimos, Marlene S. Strayer, Philip L. Ballard, Jeffrey A. Kazzaz, Simcha Pollack
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 288:L718-L726
Prolonged exposure to supraphysiological oxygen concentrations results in the generation of reactive oxygen species, which can cause significant lung injury in critically ill patients. Supplementation with human recombinant antioxidant enzymes (AOE)
Autor:
David S. Strayer, Dawn A Geverd, Hayley J McKee, Bianling Liu, Pierre Cordelier, Carmen N. Nichols, Martyn K. White, Christine B. Mitchell, Alexey A. Matskevich, Marlene S. Strayer, Rumi Kondo
Publikováno v:
Current Gene Therapy. 5:151-165
The natural function of viruses is to deliver their genetic material to cells. Among the most effective of viruses in doing that is Simian Virus-40 (SV40). The properties that make SV40 a successful virus make it an attractive candidate for use as a
Autor:
David S. Strayer, Massimo Pettoello-Mantovani, J. Roy Chowdhury, Pierre Cordelier, Marlene S. Strayer, Harris Goldstein, Siddhartha Sankar Ghosh
Publikováno v:
Clinical and Applied Immunology Reviews. 3:247-259
Progress in gene therapy of human immunodeficiency virus (HIV) infection from laboratory to bedside, as for gene therapy in general, has been slow. Many transgenes, some very innovative, have been shown to inhibit HIV in cultured cells. But translati
Autor:
Linda W. Gonzales, Rashmin C. Savani, Marlene S. Strayer, Aisha Zaman, Edina Veszelovszky, Philip L. Ballard, Emily Wood, Ye-Shih Ho, Zheng Cui
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 282:L394-L404
Surfactant protein B (SP-B) is a developmentally and hormonally regulated lung protein that is required for normal surfactant function. We generated transgenic mice carrying the human SP-B promoter (−1,039/+431 bp) linked to chloramphenicol acetylt
Autor:
Daniel J. Malone, Hshi-chi Koo, David S. Strayer, Marla R. Wolfson, Jonathan M. Davis, Thomas H. Shaffer, Marlene S. Strayer, Jichuan Wu, Jeffrey A. Kazzaz
Publikováno v:
Pulmonary Medicine
Pulmonary Medicine, Vol 2011 (2011)
Pulmonary Medicine, Vol 2011 (2011)
We compared lung delivery methods of recombinant adenovirus (rAd): (1) rAd suspended in saline, (2) rAd suspended in saline followed by a pulse-chase of a perfluorochemical (PFC) liquid mixture, and (3) a PFC-rAd suspension. Cell uptake, distribution
Autor:
Marlene S. Strayer, Pierre Cordelier, Carmen N. Nichols, Hayley J McKee, David S. Strayer, Julien Landré, Martyn K. White, Alexei Matskevitch
Recombinant gene delivery vectors derived from Tag -deleted SV40 viruses (rSV40s) are potentially useful tools for transduction of many cell types, both in culture and in animals. Characteristically, these vectors: (i) can be made to very high titers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53e348699e2ec49616b3261a32266db4
https://doi.org/10.1016/s0167-7306(03)38005-6
https://doi.org/10.1016/s0167-7306(03)38005-6
Autor:
Lokesh Agrawal, Carmen N. NiGongyi Ren, Marlene S. Strayer, Elena Marusich, Pierre Cordelier, Bianling Liu, Jean-Pierre Louboutin, David S. Strayer, Hayley J McKee
Publikováno v:
Molecular biotechnology. 34(2)
Among the goals of gene therapy is long-term expression of delivered transgenes. Recombinant Tag-deleted SV40 vectors (rSV40s) are especially well suited for this purpose. rSV40s deliver transgene expression that endures for extended periods of time
Publikováno v:
American journal of respiratory cell and molecular biology. 18(1)
We examined the ability of the human surfactant protein B (SP-B) promoter to confer cell specificity of transgene expression in an adenoviral vector. Using similar replication-deficient adenoviruses (rAd), we compared lacZ reporter gene expression dr