Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Marlene A Bunni"'
Autor:
Erin Morris Richard, Thirumagal Thiyagarajan, Marlene A Bunni, Fahmin Basher, Patrick O Roddy, Leah J Siskind, Paul J Nietert, Tamara K Nowling
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75175 (2013)
Systemic Lupus erythematosus (SLE) is an autoimmune disease caused, in part, by abnormalities in cells of the immune system including B and T cells. Genetically reducing globally the expression of the ETS transcription factor FLI1 by 50% in two lupus
Externí odkaz:
https://doaj.org/article/f8f21b58e3e24083812959898d64c66a
Autor:
Adam E. Mullick, Marlene A. Bunni, Michael R. Zile, Wayne R. Fitzgibbon, Catalin F. Baicu, Takamitsu Saigusa, Yujing Dang
Publikováno v:
American Journal of Physiology-Renal Physiology. 314:F210-F218
The intrarenal renin angiotensin system (RAS) is activated in polycystic kidney disease. We have recently shown in the Pkd1 mouse that Gen 2 antisense oligonucleotide (ASO), which suppresses angiotensinogen (Agt) synthesis, is efficacious in slowing
Publikováno v:
Am J Physiol Renal Physiol
Flow-related bending of cilia results in Ca2+ influx through a polycystin-1 (Pkd1) and polycystin-2 (Pkd2) complex, both of which are members of the transient receptor potential (TRP) family (TRPP1 and TRPP2, respectively). Deletion of this complex a
Autor:
Marlene A. Bunni, Brian J. Siroky, Bradley P. Dixon, P. Darwin Bell, John J. Bissler, Zenta Tsuchihashi, Joshua C. Dillon, Ryan J. Reichert, Thiruvamoor Ramkumar, Anna R. Hellmann, Julian R. Sampson, Hong Yin
Publikováno v:
American Journal of Physiology-Renal Physiology. 307:F560-F570
Nearly all patients with tuberous sclerosis complex (TSC) develop renal angiomyolipomas, although the tumor cell of origin is unknown. We observed decreased renal angiomyolipoma development in patients with TSC2- polycystic kidney disease 1 deletion
Publikováno v:
American Journal of Physiology-Cell Physiology. 300:C647-C656
Angiotensin II (AII) binds to G protein-coupled receptor AT1 and stimulates extracellular signal-regulated kinase (ERK), leading to vascular smooth muscle cells (VSMC) proliferation. Proliferation of mammalian cells is tightly regulated by adhesion t
Autor:
Inga I. Kramarenko, Thomas A. Morinelli, Marlene A. Bunni, John R. Raymond, Maria N. Garnovskaya
Publikováno v:
Biochemical Pharmacology. 77:269-276
The human embryonic kidney (HEK) 293 cell line is widely used in cell biology research. Although HEK293 cells have been meticulously studied, our knowledge about endogenous G protein-coupled receptors (GPCR) in these cells is incomplete. While studyi
Autor:
Jody M. Tucker, Franklin G. Berger, David G. Priest, Marlene A. Bunni, H. Trent Spencer, Celestia Davis, Maria E. Kitchens
Publikováno v:
Cancer Letters. 187:153-162
5-Fluorouracil (5-FU) has been the foundation of advanced colorectal cancer treatment for over 40 years. The Apc(Min/+) mouse, which is genetically predisposed to intestinal neoplasia, was used to examine the effects of 5-FU in this system and the im
Publikováno v:
The FASEB Journal. 28
In polycystic kidney disease (PKD) there is the continual expansion of cysts throughout the time course of this disease. The mechanisms that control the rate of cystic growth are not fully known. In PKD, the epidermal growth factor (EGF) receptor is
Autor:
Ietje Kathmann, Stavit Drori, David G. Priest, Godefridus J. Peters, Yehuda G. Assaraf, Herbert M. Pinedo, Marlene A. Bunni, Jan H. Schornagel, R. Mauritz, Paul Noordhuis, Hannah Sprecher, Gerrit Jansen
Publikováno v:
Journal of Biological Chemistry. 273:30189-30198
CEM/MTX is a subline of human CCRF-CEM leukemia cells which displays >200-fold resistance to methotrexate (MTX) due to defective transport via the reduced folate carrier (RFC). CEM/MTX-low folate (LF) cells, derived by a gradual deprivation of folic
Autor:
Julio C. Barredo, Yunhua He, Marlene A. Bunni, Kamasamudram Raghunathan, Charles E. Hill, David G. Priest, Yinong Liu
Publikováno v:
Biochemical Pharmacology. 55:2031-2037
The effect of down-regulation of folylpoly-γ-glutamate synthetase (FPGS) activity on intracellular reduced folate accumulation and cellular proliferation was examined, using an inducible antisense expression system in the human T-lymphoblastic leuke