Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Marlena Bütow"'
1
Akademický článek
Myelofibrosis at diagnosis is associated with the failure of treatment-free remission in CML patients
Autor: Henrike Jacobi, Margherita Vieri, Marlena Bütow, Carolina Y. Namasu, Laura Flüter, Ivan G. Costa, Tiago Maié, Katharina Lindemann-Docter, Nicolas Chatain, Fabian Beier, Michael Huber, Wolfgang Wagner, Martina Crysandt, Tim H. Brümmendorf, Mirle Schemionek
Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)
The management of patients with chronic myeloid leukemia (CML) has been revolutionized by the introduction of tyrosine kinase inhibitors (TKIs), which induce deep molecular responses so that treatment can eventually be discontinued, leading to treatm
Externí odkaz: https://doaj.org/article/1bcfdb9e48a74693a9367baef6ba229c
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3
Akademický článek
Infliximab therapy together with tyrosine kinase inhibition targets leukemic stem cells in chronic myeloid leukemia
Autor: Oliver Herrmann, Maja Kim Kuepper, Marlena Bütow, Ivan G. Costa, Iris Appelmann, Fabian Beier, Tom Luedde, Till Braunschweig, Steffen Koschmieder, Tim H. Brümmendorf, Mirle Schemionek
Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background Expression of Bcr-Abl in hematopoietic stem cells is sufficient to cause chronic myeloid leukemia (CML) and tyrosine kinase inhibitors (TKI) induce molecular remission in the majority of CML patients. However, the disease driving
Externí odkaz: https://doaj.org/article/2b700f2cbebb4287af92ed2f3c40b585
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5
Infliximab therapy together with tyrosine kinase inhibition targets leukemic stem cells in chronic myeloid leukemia
Autor: Till Braunschweig, Fabian Beier, Iris Appelmann, Mirle Schemionek, Oliver Herrmann, Tom Luedde, Steffen Koschmieder, Marlena Bütow, Maja Kim Kuepper, Ivan G. Costa, Tim H. Brümmendorf
Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)
BMC cancer 19, 658 (2019). doi:10.1186/s12885-019-5871-2
BMC Cancer
Background Expression of Bcr-Abl in hematopoietic stem cells is sufficient to cause chronic myeloid leukemia (CML) and tyrosine kinase inhibitors (TKI) induce molecular remission in the majority of CML patients. However, the disease driving stem cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa08c4c719f1c93e7b0152a391641a98
http://link.springer.com/article/10.1186/s12885-019-5871-2
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6
The Unfolded Protein Response Is a Major Driver of LCN2 Expression in BCR–ABL- and JAK2V617F-Positive MPN
Autor: Susanne Isfort, Vera Kathrin Preußger, Ralf Weiskirchen, Walter Becker, Tim H. Brümmendorf, Kim Kricheldorf, Marlena Bütow, Stefan Tillmann, Mirle Schemionek, Blanka Kubešová, Nicolas Chatain, Jörg Eschweiler, Steffen Koschmieder, Martina Wessiepe, Barbora Weinbergerova, Jiri Mayer, Kathrin Olschok, Sarah K. Schröder, Milena Kalmer, Julian Baumeister, Zdenek Racil
Publikováno v: Cancers
Cancers, Vol 13, Iss 4210, p 4210 (2021)
Cancers 13(16), 4210 (2021). doi:10.3390/cancers13164210 special issue: "Special Issue "Pathogenesis and Natural History of Myeloproliferative Neoplasms" / Special Issue Editor: Marco Pizzi, Guest Editor"
Volume 13
Issue 16
Lipocalin 2 (LCN2), a proinflammatory mediator, is involved in the pathogenesis of myeloproliferative neoplasms (MPN). Here, we investigated the molecular mechanisms of LCN2 overexpression in MPN. LCN2 mRNA expression was 20-fold upregulated in perip
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b68400919e4bc9ee410a046fcf37d1
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7
Identification of a Novel High Yielding Source of Multipotent Adult Human Neural Crest-Derived Stem Cells
Autor: Christian Kaltschmidt, Holger Sudhoff, Matthias Schürmann, Johannes F. W. Greiner, Barbara Kaltschmidt, Viktoria Brotzmann, Marlena Bütow, Anna L. Höving
Publikováno v: Stem Cell Reviews and Reports. 14:277-285
Due to their extraordinarily broad differentiation potential and persistence during adulthood, adult neural crest-derived stem cells (NCSCs) are highly promising candidates for clinical applications, particularly when facing the challenging treatment
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9b052df3fb27a53f3c725ecbc1ebf3
https://doi.org/10.1007/s12015-017-9797-2
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8
The Unfolded Protein Response Mediates Resistance in AML and Its Therapeutic Targeting Enhances TKI Induced Cell Death in FLT3-ITD + AML
Autor: Michael Huber, Steffen Koschmieder, Timo Jaquet, Edgar Jost, Iris Appelmann, Marlena Bütow, Mirle Schemionek, Stefan Tillmann, Martin Kirschner, Nicolas Chatain, Tim H. Brümmendorf, Bezhad Kharabi, Christian Preisinger
Publikováno v: Blood. 138:2246-2246
Introduction: The unfolded protein response (UPR) is a stress sensing signaling network that is activated upon endoplasmic reticulum (ER) stress, a condition characterized by an accumulation of mis- and unfolded proteins in the ER. To retain a functi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2aa025d89b27a04f081d561b0b0ba58
https://doi.org/10.1182/blood-2021-150066
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9
Stem cell persistence in CML is mediated by extrinsically activated JAK1-STAT3 signaling
Autor: Martin Kirschner, Gerhard Müller-Newen, Marlena Bütow, Nicolas Chatain, Tiago Maié, Tim H. Brümmendorf, Jörg Eschweiler, Ivan G. Costa, Oliver Herrmann, Angela Maurer, Janine Ziemons, Steffen Koschmieder, Maja Kim Kuepper, Mirle Schemionek
Publikováno v: Leukemia. 33(8)
Tyrosine kinase inhibitor (TKI) therapy effectively blocks oncogenic Bcr-Abl signaling and induces molecular remission in the majority of CML patients. However, the disease-driving stem cell population is not fully targeted by TKI therapy in the majo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8306866a7dd5e1cf68f56e646227f0b
https://pubmed.ncbi.nlm.nih.gov/30842608
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