Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Marlena A. Moors"'
Publikováno v:
The Journal of Immunology. 170:6217-6223
The induction of cytokine synthesis by flagellin is mediated by a Toll-like receptor 5 (TLR5) signaling pathway. Although flagellin activation of the IL-1R-associated kinase and induction of TNF-α synthesis are dependent on TLR5 and not TLR4, we hav
Autor:
Steven B. Mizel, Marlena A. Moors
Publikováno v:
Journal of Leukocyte Biology. 68:131-136
Interleukin-1β is a secreted protein that accumulates in the cytosol as an inactive precursor (pIL-1β) before processing and release of biologically active protein. To understand the impact of this property on IL-1β production, we examined the int
Publikováno v:
Infection and Immunity. 67:131-139
Listeria monocytogenes requires listeriolysin O (LLO) and ActA, the products of hly and actA , respectively, to establish a productive intracellular infection. LLO is essential for vacuolar lysis and entry into the cytosol, while ActA is required for
Publikováno v:
Molecular Microbiology. 23:1075-1085
All known virulence genes of Listeria monocytogenes are under positive regulation by the transcription factor PrfA. Previous work employing the L. monocytogenes strain NCTC7973 suggested that the disaccharide cellobiose might serve as a specific "sig
Publikováno v:
Immunopharmacology. 24:203-217
Methylxanthines have been shown to have a variety of effects on hematopoietic cell activation and function. These compounds inhibit cAMP-specific phosphodiesterase activity resulting in increased levels of intracellular cAMP. In the present study, we
Publikováno v:
The Journal of Experimental Medicine
Candida albicans, an opportunistic fungal pathogen of humans, is dependent upon iron for growth. Consequently, human serum inhibits C. albicans growth due to the presence of high affinity iron-binding proteins that sequester serum iron, making it una
Publikováno v:
Viral Immunology. 5:201-211
To investigate the mechanism by which Friend leukemia virus (FV) causes immunosuppression, the ability of peritoneal macrophages to mediate antigen-specific T-cell activation following FV infection was examined. Decreased IL-2 production was observed
Publikováno v:
Infection and Immunity. 58:1796-1801
Previous studies have demonstrated that Friend leukemia virus (FLV) induces a profound immunosuppression in susceptible mice. The studies described in this report indicate that mice infected with FLV have an increased susceptibility to subsequent inf
Publikováno v:
Science (New York, N.Y.). 302(5644)
Listeria monocytogenes is a Gram-positive intracytosolic pathogen that causes severe disease in pregnant and immunocompromised individuals. We found that L. monocytogenes lacking the lipoate protein ligase LplA1 was defective for growth specifically
Publikováno v:
Infection and immunity. 69(7)
Flagellin from various species of gram-negative bacteria activates monocytes to produce proinflammatory cytokines. We have analyzed the pathway by whichSalmonella enteritidisflagellin (FliC) activates murine and human monocyte/macrophage-like cell li