Výsledky vyhledávání - "Marleen van Geest"

Akademický článek

Type‐2 airway inflammation in mild asthma patients with high blood eosinophils and high fractional exhaled nitric oxide

Autor: Thomas Southworth, Marleen Van Geest, Dave Singh

Publikováno v: Clinical and Translational Science, Vol 14, Iss 4, Pp 1259-1264 (2021)

Abstract Type‐2 (T2) inflammation is a characteristic feature of asthma. Biological therapies have been developed to target T2‐inflammation in asthma. IL‐13 is a key component of T2‐inflammation in asthma, driving mucus hypersecretion, IgE‐

Externí odkaz: https://doaj.org/article/24b402f6c3f740669acec18bcc2f9688

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A novel non-invasive method allowing for discovery of pathologically relevant proteins from small airways

Autor: Ekaterina Mirgorodskaya, Jörgen Östling, Marleen van Geest, Emilia Viklund, Anna-Carin Olin, Henric Olsson, Per M. Gustafsson, Sven-Erik Dahlén

Publikováno v: Clinical Proteomics. 19

Background There is a lack of early and precise biomarkers for personalized respiratory medicine. Breath contains an aerosol of droplet particles, which are formed from the epithelial lining fluid when the small airways close and re-open during inhal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe6f9b6e230974238ec8669aaa0c063
https://doi.org/10.1186/s12014-022-09348-y

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Association of differential mast cell activation with granulocytic inflammation in severe asthma

Publikováno v: U-BIOPRED Consortium Project Team 2022, ' Association of Differential Mast Cell Activation with Granulocytic Inflammation in Severe Asthma ', American Journal of Respiratory and Critical Care Medicine, vol. 205, no. 4, pp. 397-411 . https://doi.org/10.1164/rccm.202102-0355OC
American journal of respiratory and critical care medicine, 205(4), 397-411. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine, 205(4), 397-411. American Thoracic Society

Rationale: Mast cells (MCs) play a role in inflammation and both innate and adaptive immunity, but their involvement in severe asthma (SA) remains undefined. Objectives: We investigated the phenotypic characteristics of the U-BIOPRED (Unbiased Biomar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0769f3396c2d0e280947dd7c7b135cf2
https://ruj.uj.edu.pl/xmlui/handle/item/290001

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Type-2 airway inflammation in mild asthma patients with high blood eosinophils and high fractional exhaled nitric oxide

Autor: Dave Singh, Thomas Southworth, Marleen van Geest

Publikováno v: Clinical and Translational Science
Clinical and Translational Science, Vol 14, Iss 4, Pp 1259-1264 (2021)

Type‐2 (T2) inflammation is a characteristic feature of asthma. Biological therapies have been developed to target T2‐inflammation in asthma. IL‐13 is a key component of T2‐inflammation in asthma, driving mucus hypersecretion, IgE‐induction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418f0df397cb086b984bd1220001eaec
https://pubmed.ncbi.nlm.nih.gov/34106513

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Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation

Autor: Zala Jevnikar, Jörgen Östling, Elisabeth Ax, Jenny Calvén, Kristofer Thörn, Elisabeth Israelsson, Lisa Öberg, Akul Singhania, Laurie C.K. Lau, Susan J. Wilson, Jonathan A. Ward, Anoop Chauhan, Ana R. Sousa, Bertrand De Meulder, Matthew J. Loza, Frédéric Baribaud, Peter J. Sterk, Kian Fan Chung, Kai Sun, Yike Guo, Ian M. Adcock, Debbie Payne, Barbro Dahlen, Pascal Chanez, Dominick E. Shaw, Norbert Krug, Jens M. Hohlfeld, Thomas Sandström, Ratko Djukanovic, Anna James, Timothy S.C. Hinks, Peter H. Howarth, Outi Vaarala, Marleen van Geest, Henric Olsson, I.M. Adcock, H. Ahmed, C. Auffray, P. Bakke, A.T. Bansal, F. Baribaud, S. Bates, E.H. Bel, J. Bigler, H. Bisgaard, M.J. Boedigheimer, K. Bønnelykke, J. Brandsma, P. Brinkman, E. Bucchioni, D. Burg, A. Bush, M. Caruso, A. Chaiboonchoe, P. Chanez, F.K. Chung, C.H. Compton, J. Corfield, A. D'Amico, S.E. Dahlen, B. De Meulder, R. Djukanovic, V.J. Erpenbeck, D. Erzen, K. Fichtner, N. Fitch, L.J. Fleming, E. Formaggio, S.J. Fowler, U. Frey, M. Gahlemann, T. Geiser, V. Goss, Y. Guo, S. Hashimoto, J. Haughney, G. Hedlin, P.W. Hekking, T. Higenbottam, J.M. Hohlfeld, C. Holweg, I. Horváth, A.J. James, R. Knowles, A.J. Knox, N. Krug, D. Lefaudeux, M.J. Loza, A. Manta, J.G. Matthews, A. Mazein, A. Meiser, R.J.M. Middelveld, M. Miralpeix, P. Montuschi, N. Mores, C.S. Murray, J. Musial, D. Myles, L. Pahus, I. Pandis, S. Pavlidis, A. Postle, P. Powel, G. Praticò, N. Rao, J. Riley, A. Roberts, G. Roberts, A. Rowe, T. Sandström, J.P.R. Schofield, W. Seibold, A. Selby, D.E. Shaw, R. Sigmund, F. Singer, P.J. Skipp, A.R. Sousa, P.J. Sterk, K. Sun, B. Thornton, W.M. van Aalderen, M. van Geest, J. Vestbo, N.H. Vissing, A.H. Wagener, S.S. Wagers, Z. Weiszhart, C.E. Wheelock, S.J. Wilson

Publikováno v: Jevnikar, Zala; Östling, Jörgen; Ax, Elisabeth; Calvén, Jenny; Thörn, Kristofer; Israelsson, Elisabeth; Öberg, Lisa; Singhania, Akul; Lau, Laurie C K; Wilson, Susan J; Ward, Jonathan A; Chauhan, Anoop; Sousa, Ana R; De Meulder, Bertrand; Loza, Matthew J; Baribaud, Frédéric; Sterk, Peter J; Chung, Kian Fan; Sun, Kai; Guo, Yike; ... (2019). Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation. Journal of allergy and clinical immunology, 143(2), pp. 577-590. Elsevier 10.1016/j.jaci.2018.05.026
Journal of allergy and clinical immunology, 143(2), 577-590. Mosby Inc.
Jevnikar, Z, Östling, J, Ax, E, Calvén, J, Thörn, K, Israelsson, E, Öberg, L, Singhania, A, Lau, L C K, Wilson, S J, Ward, J A, Chauhan, A, Sousa, A R, De Meulder, B, Loza, M J, Baribaud, F, Sterk, P J, Chung, K F, Sun, K, Guo, Y, Adcock, I M, Payne, D, Dahlen, B, Chanez, P, Shaw, D E, Krug, N, Hohlfeld, J M, Sandström, T, Djukanovic, R, James, A, Hinks, T S C, Howarth, P H, Vaarala, O, Van Geest, M, Olsson, H, Adcock, I M, Ahmed, H, Auffray, C, Bakke, P, Bansal, A T, Baribaud, F, Bates, S, Bel, E H, Bigler, J, Bisgaard, H, Boedigheimer, M J, Bønnelykke, K, Brandsma, J, Brinkman, P, Bucchioni, E, Burg, D, Bush, A, Caruso, M, Chaiboonchoe, A, Chanez, P, Chung, F K, Compton, C H, Corfield, J, D'amico, A, Dahlen, S E, De Meulder, B, Djukanovic, R, Erpenbeck, V J, Erzen, D, Fichtner, K, Fitch, N, Fleming, L J, Formaggio, E, Fowler, S J, Frey, U, Gahlemann, M, Geiser, T, Goss, V, Guo, Y, Hashimoto, S, Haughney, J, Hedlin, G, Hekking, P W, Higenbottam, T, Hohlfeld, J M, Holweg, C, Horváth, I, James, A J, Knowles, R, Knox, A J, Krug, N, Lefaudeux, D, Loza, M J, Manta, A, Matthews, J G, Mazein, A, Meiser, A, Middelveld, R J M, Miralpeix, M, Montuschi, P, Mores, N, Murray, C S, Musial, J, Myles, D, Pahus, L, Pandis, I, Pavlidis, S, Postle, A, Powel, P, Praticò, G, Rao, N, Riley, J, Roberts, A, Roberts, G, Rowe, A, Sandström, T, Schofield, J P R, Seibold, W, Selby, A, Shaw, D E, Sigmund, R, Singer, F, Skipp, P J, Sousa, A R, Sterk, P J, Sun, K, Thornton, B, Van Aalderen, W M, Van Geest, M, Vestbo, J, Vissing, N H, Wagener, A H, Wagers, S S, Weiszhart, Z, Wheelock, C E & Wilson, S J 2018, ' Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation ', Journal of Allergy and Clinical Immunology . https://doi.org/10.1016/j.jaci.2018.05.026

BackgroundAlthough several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) to asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) in asthmatic patients is unclear.ObjectiveWe sought to explore th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab73d68f4dbf9b501c650ac563ec4c72
https://eprints.soton.ac.uk/421475/

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Late Breaking Abstract - Aging change the protein-profile of lining fluid from small airways

Autor: Marleen van Geest, Per A. Gustafsson, Emilia Viklund, Ekaterina Mirgorodskaya, Jörgen Östling, Anna-Carin Olin

Publikováno v: Monitoring Airway Disease.

An exaggerated aging process of the lung is suggested to play role in development of respiratory disease. Detailed information on the macro molecular make up of the lining fluid and how that changes over time and with disease is still scarce. When an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1deeab8fc107a76becf6d26c76c5d11e
https://doi.org/10.1183/1393003.congress-2017.oa3211

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Late Breaking Abstract - Exploring particles from exhaled air as a new source for protein biomarkers from the airways

Autor: Jörgen Östling, Anna-Carin Olin, Ekaterina Mirgorodskaya, Marleen van Geest, Emilia Viklund, Per A. Gustafsson

Publikováno v: Monitoring Airway Disease.

Although highly desired, there are currently no non-invasive methods to collect samples from distal airways for robust biomarker analysis. Breath contains particles which are formed in small airways when the lining fluid bursts during inhalation. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b8c9722ff465938504fff1be3902f9d
https://doi.org/10.1183/1393003.congress-2017.oa2933

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