Comprehensive evaluation of smoking exposures and their interactions on DNA methylationResearch in context

Autor: Thanh T. Hoang, Yunsung Lee, Daniel L. McCartney, Elin T.G. Kersten, Christian M. Page, Paige M. Hulls, Mikyeong Lee, Rosie M. Walker, Charles E. Breeze, Brian D. Bennett, Adam B. Burkholder, James Ward, Anne Lise Brantsæter, Ida H. Caspersen, Alison A. Motsinger-Reif, Marie Richards, Julie D. White, Shanshan Zhao, Rebecca C. Richmond, Maria C. Magnus, Gerard H. Koppelman, Kathryn L. Evans, Riccardo E. Marioni, Siri E. Håberg, Stephanie J. London, Bastiaan Heijmans, Peter ’t Hoen, Joyce van Meurs, Rick Jansen, Lude Franke, Dorret Boomsma, René Pool, Jenny van Dongen, Jouke Hottenga, Marleen van Greevenbroek, Coen Stehouwer, Carla van der Kallen, Casper Schalkwijk, Cisca Wijmenga, Sasha Zhernakova, Ettje Tigchelaar, P. Eline Slagboom, Marian Beekman, Joris Deelen, Diana Van Heemst, Jan Veldink, Leonard van den Berg, Cornelia van Duijn, Bert Hofman, Aaron Isaacs, André Uitterlinden, P. Mila Jhamai, Michael Verbiest, H. Eka Suchiman, Marijn Verkerk, Ruud van der Breggen, Jeroen van Rooij, Nico Lakenberg, Hailiang Mei, Maarten van Iterson, Michiel van Galen, Jan Bot, Dasha Zhernakova, Peter van ‘t Hof, Patrick Deelen, Irene Nooren, Matthijs Moed, Martijn Vermaat, René Luijk, Marc Bonder, Freerk van Dijk, Wibowo Arindrarto, Szymon Kielbasa, Morris Swertz, Erik van Zwet

Publikováno v: EBioMedicine, Vol 100, Iss , Pp 104956- (2024)

Summary: Background: Smoking impacts DNA methylation, but data are lacking on smoking-related differential methylation by sex or dietary intake, recent smoking cessation (

Externí odkaz: https://doaj.org/article/3985b627485b4ff999b2ec073dfaf4e4

Sulfur amino acid restriction, energy metabolism and obesity: a study protocol of an 8-week randomized controlled dietary intervention with whole foods and amino acid supplements

Autor: Emma Stolt, Thomas Olsen, Amany Elshorbagy, Viktor Kožich, Marleen van Greevenbroek, Bente Øvrebø, Magne Thoresen, Helga Refsum, Kjetil Retterstøl, Kathrine J. Vinknes

Publikováno v: Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-11 (2021)

Abstract Background Dietary sulfur amino acid (SAA) restriction is an established animal model for increasing lifespan and improving metabolic health. Data from human studies are limited. In the study outlined in this protocol, we will evaluate if di

Externí odkaz: https://doaj.org/article/8633d494d2174997953b3d11811e9b06

P151 Microvascular Dysfunction is Associated with Impaired Beta-cell Function: The Maastricht Study

Autor: Wenjie Li, Alfons Houben, Tos Berendschot, Carroll Webers, Abraham Kroon, Marleen van Greevenbroek, Carla van der Kallen, Ronald Henry, Simone Sep, Pieter Dagnelie, Nicolaas Schaper, Simone Eussen, Casper Schalkwijk, Miranda Schram, Coen Stehouwer

Publikováno v: Artery Research, Vol 25, Iss S1, Pp S188-S188 (2020)

Abstract Background The pathophysiological mechanism underlying beta-cell dysfunction in type 2 diabetes (T2D) is not fully understood. Recent animal studies suggest that microvascular dysfunction (MVD) may lead to insufficient delivery of oxygen and

Externí odkaz: https://doaj.org/article/a4118b97044e4cb6affa5102de05e21d

Genetically proxied ketohexokinase function and risk of colorectal cancer

Autor: Amée M Buziau, Philip J Law, Gabriella Blokland, Casper Schalkwijk, Jean Scheijen, Pomme Simons, Carla van der Kallen, Simone Eussen, Pieter C Dagnelie, Marleen van Greevenbroek, Richard S Houlston, Anke Wesselius, Molly Went, Coen Stehouwer, Martijn CGJ Brouwers

Publikováno v: Gut, 72(3), 604-606. BMJ Publishing Group

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0403274085bd3c272a2969f6ea40e7
https://doi.org/10.1136/gutjnl-2021-326299

Metabolomics Profile in Depression: A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls

Autor: Mariska Bot, Yuri Milaneschi, Tahani Al-Shehri, Najaf Amin, Sanzhima Garmaeva, Gerrit L.J. Onderwater, Rene Pool, Carisha S. Thesing, Lisanne S. Vijfhuizen, Nicole Vogelzangs, Ilja C.W. Arts, Ayse Demirkan, Cornelia van Duijn, Marleen van Greevenbroek, Carla J.H. van der Kallen, Sebastian Köhler, Lannie Ligthart, Arn M.J.M. van den Maagdenberg, Dennis O. Mook-Kanamori, Renée de Mutsert, Henning Tiemeier, Miranda T. Schram, Coen D.A. Stehouwer, Gisela M. Terwindt, Ko Willems van Dijk, Jingyuan Fu, Alexandra Zhernakova, Marian Beekman, P. Eline Slagboom, Dorret I. Boomsma, Brenda W.J.H. Penninx, M. Beekman, H.E.D. Suchiman, J. Deelen, N. Amin, J.W. Beulens, J.A. van der Bom, N. Bomer, A. Demirkan, J.A. van Hilten, J.M.T.A. Meessen, R. Pool, M.H. Moed, J. Fu, G.L.J. Onderwater, F. Rutters, C. So-Osman, W.M. van der Flier, A.A.W.A. van der Heijden, A. van der Spek, F.W. Asselbergs, E. Boersma, P.M. Elders, J.M. Geleijnse, M.A. Ikram, M. Kloppenburg, I. Meulenbelt, S.P. Mooijaart, R.G.H.H. Nelissen, M.G. Netea, B.W.J.H. Penninx, C.D.A. Stehouwer, C.E. Teunissen, G.M. Terwindt, L.M. ’t Hart, A.M.J.M. van den Maagdenberg, P. van der Harst, I.C.C. van der Horst, C.J.H. van der Kallen, M.M.J. van Greevenbroek, W.E. van Spil, C. Wijmenga, A.H. Zwinderman, A. Zhernikova, J.W. Jukema, N. Sattar

Publikováno v: Biological Psychiatry, 87(5), 409-418. Elsevier USA
Biological Psychiatry 87 (2020) 5
Biological Psychiatry, 87(5), 409-418. Elsevier Inc.
Bot, M, Milaneschi, Y, Pool, R, Ligthart, L, Boomsma, D I, Penninx, B W J H & BBMRI-NL Metabolomics Consortium 2020, ' Metabolomics Profile in Depression : A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls ', Biological Psychiatry, vol. 87, no. 5, pp. 409-418 . https://doi.org/10.1016/j.biopsych.2019.08.016
Biological Psychiatry, 87(5), 409-418. ELSEVIER SCIENCE INC
Bot, M, Milaneschi, Y, Al-Shehri, T, Amin, N, Garmaeva, S, Onderwater, G L J, Pool, R, Thesing, C S, Vijfhuizen, L S, Vogelzangs, N, Arts, I C W, Demirkan, A, van Duijn, C, van Greevenbroek, M, van der Kallen, C J H, Köhler, S, Ligthart, L, van den Maagdenberg, A M J M, Mook-Kanamori, D O, de Mutsert, R, Tiemeier, H, Schram, M T, Stehouwer, C D A, Terwindt, G M, Willems van Dijk, K, Fu, J, Zhernakova, A, Beekman, M, Slagboom, P E, Boomsma, D I, Penninx, B W J H & BBMRI-NL Metabolomics Consortium 2020, ' Metabolomics Profile in Depression : A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls ', Biological Psychiatry, vol. 87, no. 5, pp. 409-418 . https://doi.org/10.1016/j.biopsych.2019.08.016
Biological Psychiatry, 87(5), 409-418
Biological psychiatry, 87(5), 409-418. Elsevier USA
Biological Psychiatry, 87(5), 409-418. Elsevier Science

BACKGROUND: Depression has been associated with metabolic alterations, which adversely impact cardiometabolic health. Here, a comprehensive set of metabolic markers, predominantly lipids, was compared between depressed and nondepressed persons.METHOD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141ca276e01652d358b036a24f2db3bb
https://research.vu.nl/en/publications/09cd043a-37e7-4ac0-be42-2b5efff3847d