A Vasopressin-Induced Change in Prostaglandin Receptor Subtype Expression Explains the Differential Effect of PGE2 on AQP2 Expression

Autor: Peter M. T. Deen, Michelle Boone, Horst Schweer, Emma T. B. Olesen, Claudia Carmone, Jack F. M. Wetzels, Robert A. Fenton, Marleen L. A. Kortenoeven

Publikováno v: Frontiers in Physiology, Vol 12 (2022)

Arginine vasopressin (AVP) stimulates the concentration of renal urine by increasing the principal cell expression of aquaporin-2 (AQP2) water channels. Prostaglandin E2 (PGE2) and prostaglandin2α (PGF2α) increase the water absorption of the princi

Externí odkaz: https://doaj.org/article/fbd4552394a74737835c4a9ef2b60e49

Activation of the kidney sodium chloride cotransporter by the β2-adrenergic receptor agonist salbutamol increases blood pressure

Autor: Johannes Loffing, Robert Little, Søren Brandt Poulsen, Sathish K. Murali, Marleen L. A. Kortenoeven, Lei Cheng, Robert A. Fenton, David Penton, Vladimir V. Matchkov

Publikováno v: Poulsen, S B, Cheng, L, Penton, D, Kortenoeven, M L A, Matchkov, V V, Loffing, J, Little, R, Murali, S K & Fenton, R A 2021, ' Activation of the kidney sodium chloride cotransporter by the β2-adrenergic receptor agonist salbutamol increases blood pressure ', Kidney International, vol. 100, no. 2, pp. 321-335 . https://doi.org/10.1016/j.kint.2021.04.021

The thiazide-sensitive sodium-chloride-cotransporter (NCC) in the kidney distal convoluted tubule (DCT) plays an essential role in sodium and potassium homeostasis. Here, we demonstrate that NCC activity is increased by the β2-adrenoceptor agonist s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec93dd6d32f835cd70d945d87a1a1c8e
https://doi.org/10.1016/j.kint.2021.04.021

An in vivo protein landscape of the mouse DCT during high dietary K+ or low dietary Na+ intake

Autor: Qi Wu, Lei Cheng, Marleen L. A. Kortenoeven, Robert A. Fenton

Publikováno v: Kortenoeven, M LA, Cheng, L, Wu, Q & Fenton, R A 2021, ' An in vivo protein landscape of the mouse DCT during high dietary K + or low dietary Na + intake ', American Journal of Physiology: Renal Physiology, vol. 320, no. 5, pp. F908-F921 . https://doi.org/10.1152/ajprenal.00064.2021
Kortenoeven, M L A, Cheng, L, Wu, Q & Fenton, R A 2021, ' An in vivo protein landscape of the mouse DCT during high dietary K+ or low dietary Na+ intake ', American Journal of Physiology-Renal Physiology, vol. 320, no. 5, pp. F908-F921 . https://doi.org/10.1152/ajprenal.00064.2021

The hormone aldosterone is essential for maintaining K+ and Na+ balance and controlling blood pressure. Aldosterone has different effects if it is secreted due to hypovolemia or hyperkalemia. The kidney distal convoluted tubule (DCT) is believed to p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d7da13f14595cc51efd5b30051ea72
https://doi.org/10.1152/ajprenal.00064.2021

High dietary potassium causes ubiquitin-dependent degradation of the kidney sodium-chloride cotransporter

Autor: Sathish K. Murali, Marleen L. A. Kortenoeven, Henrik Dimke, Robert A. Fenton, Cristina Esteva-Font, Søren Brandt Poulsen

Publikováno v: Kortenoeven, M L A, Esteva-Font, C, Dimke, H, Poulsen, S B, Murali, S K & Fenton, R A 2021, ' High dietary potassium causes ubiquitin-dependent degradation of the kidney sodium-chloride cotransporter ', The Journal of biological chemistry, vol. 297, no. 2, 100915 . https://doi.org/10.1016/j.jbc.2021.100915
Kortenoeven, M L A, Esteva-Font, C, Dimke, H, Poulsen, S B, Murali, S K & Fenton, R A 2021, ' High dietary potassium causes ubiquitin-dependent degradation of the kidney sodium-chloride cotransporter ', The Journal of Biological Chemistry, vol. 297, no. 2, 100915 . https://doi.org/10.1016/j.jbc.2021.100915
The Journal of Biological Chemistry

The thiazide-sensitive sodium-chloride cotransporter (NCC) in the renal distal convoluted tubule (DCT) plays a critical role in regulating blood pressure (BP) and K+ homeostasis. During hyperkalemia, reduced NCC phosphorylation and total NCC abundanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373a624fd8fd142a9c740843c2731f0e
https://findresearcher.sdu.dk:8443/ws/files/184489721/PIIS0021925821007158.pdf

Lithium induces aerobic glycolysis and glutaminolysis in collecting duct principal cells

Autor: Melissa Bekkenkamp-Grovenstein, Mohammad Alsady, Theun de Groot, Ron A. Wevers, Udo F. H. Engelke, Kim Neijman, Ron Korstanje, Peter M.T. Deen, Ruben Baumgarten, Claudia Carmone, Marleen L. A. Kortenoeven

Publikováno v: Alsady, M, de Groot, T, Kortenoeven, M L A, Carmone, C, Neijman, K, Bekkenkamp-Grovenstein, M, Engelke, U, Wevers, R, Baumgarten, R, Korstanje, R & Deen, P M T 2018, ' Lithium induces aerobic glycolysis and glutaminolysis in collecting duct principal cells ', American Journal of Physiology: Renal Physiology, vol. 314, no. 2, pp. F230-F239 . https://doi.org/10.1152/ajprenal.00297.2017
American Journal of Physiology : Renal Physiology, 314, 2, pp. F230-F239
American Journal of Physiology : Renal Physiology, 314, F230-F239

Lithium, given to bipolar disorder patients, causes nephrogenic diabetes insipidus (Li-NDI), a urinary-concentrating defect. Li-NDI occurs due to downregulation of principal cell AQP2 expression, which coincides with principal cell proliferation. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a24cafc61c69a05978d675ab7b8f40
https://hdl.handle.net/2066/187819