Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Marleen Derweduwe"'
Single‐cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma
Autor:
Lise Finotto, Basiel Cole, Wolfgang Giese, Elisabeth Baumann, Annelies Claeys, Maxime Vanmechelen, Brecht Decraene, Marleen Derweduwe, Nikolina Dubroja Lakic, Gautam Shankar, Madhu Nagathihalli Kantharaju, Jan Philipp Albrecht, Ilse Geudens, Fabio Stanchi, Keith L Ligon, Bram Boeckx, Diether Lambrechts, Kyle Harrington, Ludo Van Den Bosch, Steven De Vleeschouwer, Frederik De Smet, Holger Gerhardt
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp n/a-n/a (2023)
Abstract Glioblastoma (GBM) remains the most malignant primary brain tumor, with a median survival rarely exceeding 2 years. Tumor heterogeneity and an immunosuppressive microenvironment are key factors contributing to the poor response rates of curr
Externí odkaz:
https://doaj.org/article/976910c5b9a04a05a8d793a2fa75c789
Autor:
Sweta Parik, Juan Fernández-García, Francesca Lodi, Karen De Vlaminck, Marleen Derweduwe, Steven De Vleeschouwer, Raf Sciot, Wietse Geens, Linqian Weng, Francesca Maria Bosisio, Gabriele Bergers, Johnny Duerinck, Frederick De Smet, Diether Lambrechts, Jo A. Van Ginderachter, Sarah-Maria Fendt
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Glioblastoma is a highly lethal grade of astrocytoma with very low median survival. Despite extensive efforts, there is still a lack of alternatives that might improve these prospects. We uncovered that the chemotherapeutic agent temozolomide impinge
Externí odkaz:
https://doaj.org/article/9b367757c6e54473af57787cad0920a8
Autor:
Evelyne Naus, Marleen Derweduwe, Youlia Lampi, Annelies Claeys, Jarne Pauwels, Tobias Langenberg, Filip Claes, Jie Xu, Veerle Haemels, Zeynep Kalender Atak, Rob van der Kant, Joost Van Durme, Greet De Baets, Keith L. Ligon, Mark Fiers, Kris Gevaert, Stein Aerts, Frederic Rousseau, Joost Schymkowitz, Frederik De Smet
Publikováno v:
Cells, Vol 12, Iss 6, p 960 (2023)
In malignant cancer, excessive amounts of mutant p53 often lead to its aggregation, a feature that was recently identified as druggable. Here, we describe that induction of a heat shock-related stress response mediated by Foldlin, a small-molecule to
Externí odkaz:
https://doaj.org/article/37999acd49cb4597b94c46b713bf272c
Autor:
Dena Panovska, Pouya Nazari, Basiel Cole, Pieter-Jan Creemers, Marleen Derweduwe, Lien Solie, Sofie Van Gassen, Annelies Claeys, Tatjana Verbeke, Elizabeth F. Cohen, Michael Y. Tolstorukov, Yvan Saeys, David Van der Planken, Francesca M. Bosisio, Eric Put, Sven Bamps, Paul M. Clement, Michiel Verfaillie, Raf Sciot, Keith L. Ligon, Steven De Vleeschouwer, Asier Antoranz, Frederik De Smet
Publikováno v:
Cellular and Molecular Life Sciences. 80
Autor:
Lise Finotto, Basiel Cole, Wolfgang Giese, Elisabeth Baumann, Annelies Claeys, Maxime Vanmechelen, Brecht Decraene, Marleen Derweduwe, Nikolina Dubroja Lakic, Gautam Shankar, Madhu Nagathihalli Kantharaju, Jan Philipp Albrecht, Ilse Geudens, Fabio Stanchi, Keith L. Ligon, Bram Boeckx, Diether Lambrechts, Kyle Harrington, Ludo Van Den Bosch, Steven De Vleeschouwer, Frederik De Smet, Holger Gerhardt
Glioblastoma (GBM) remains the most malignant primary brain tumor, with a median survival rarely exceeding 2 years. Tumor heterogeneity and an immunosuppressive microenvironment are key factors contributing to the poor response rates of current thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9249920d6362973148352d262e3d00f6
https://doi.org/10.1101/2023.04.27.538517
https://doi.org/10.1101/2023.04.27.538517
Autor:
Dena Panovska, Pouya Nazari, Basiel Cole, Pieter-Jan Creemers, Marleen Derweduwe, Lien Solie, Sofie Van Gassen, Annelies Claeys, Tatjana Verbeke, Yvan Saeys, David Van Der Plancken, Francesca M. Bosisio, Eric Put, Sven Bamps, Paul M. Clement, Michiel Verfaillie, Raf Sciot, Keith L. Ligon, Steven De Vleeschouwer, Asier Antoranz, Frederik De Smet
BackgroundFunctional profiling of freshly isolated glioblastoma cells is being evaluated as a next-generation method for precision oncology. While promising, its success largely depends on the method to evaluate treatment activity which requires suff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d9eecd023d16b887da25b58e245b62
https://doi.org/10.21203/rs.3.rs-2304487/v1
https://doi.org/10.21203/rs.3.rs-2304487/v1
Autor:
Pouya Nasari, Frederic Rousseau, Gabriele Orlando, Lien Solie, Dena Panovska, Marleen Derweduwe, Keith L. Ligon, Paul Clement, M. Verfaillie, Sofie Van Gassen, Frederik De Smet, Annelies Claeys, Raf Sciot, Joost Schymkowitz, Asier Antoranz, David Van der Planken, Tatjana Verbeke, Yvan Saeys, Pieter-Jan Creemers, Steven De Vleeschouwer
Publikováno v:
Neuro Oncol
Glioblastoma (GBM) remains a highly malignant and incurable brain tumour. The inability to achieve clinical improvements in GBM treatment can be attributed to the excessive heterogeneity and plasticity of GBM cells, which is reflected by the presence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd7fbf884cf613f305d14fb17c88cde
https://europepmc.org/articles/PMC8598600/
https://europepmc.org/articles/PMC8598600/
Autor:
Brecht Decraene, Asier Antoranz, Tatjana Verbeke, Maxime Vanmechelen, Pouya Nazari, Lien Solie, Nikolina Dubroja, Marleen Derweduwe, Lien Spans, Isabelle Vanden Bempt, Raf Sciot, Frederik De Smet, Steven De Vleeschouwer
Publikováno v:
Neuro-Oncology. 24:vii279-vii279
Glioblastoma Multiforme (GBM) remains the most common malignant primary brain tumor with a dismal prognosis that rarely exceeds beyond two years despite extensive therapy, which consists of maximal safe surgical resection, radiotherapy and/or chemoth
Autor:
Yanti De Visser, Dena Panovska, Basiel Cole, Lotte Hermans, Asier Antoranz Martinez, Pouya Nazari, Maaike Van Trimpont, Marleen Derweduwe, Annelies Claeys, Steven De Vleeschouwer, Lien Solie, Paul Clement, Raf Sciot, Michiel Verfaillie, Thomas Daenekindt, Sven Bamps, Pieter Van Vlierberghe, Frederik De Smet
Publikováno v:
Neuro-Oncology. 24:vii7-vii7
Glioblastoma remains a highly malignant and intrinsically resistant brain tumor. Despite intensive research through which numerous potential druggable targets were identified, virtually all clinical trials of the past 20 years failed to improve the o
Autor:
Julie Messiaen, Annelies Claeys, Aniket Shetty, Lien Spans, Marleen Derweduwe, Anne Uyttebroeck, Bart Depreitere, Isabelle Vanden Bempt, Raf Sciot, Keith Ligon, David Jones, Sandra Jacobs, Frederik De Smet
Publikováno v:
Neuro-Oncology. 24:i155-i156
Diffuse leptomeningeal glioneuronal tumors (DLGNT) are rare neoplasms of the central nervous system. We describe the generation of patient-derived models from a DLGNT that metastasized to the peritoneal cavity via a ventriculoperitoneal shunt in a ch