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of 19
pro vyhledávání: '"Marla K. Perna"'
Disorders of creatine (Cr) synthesis and transport cause moderate to severe intellectual disability, epilepsy, and a lack of speech development. Mutations of the X-linked Cr transporter (CrT; SLC6A8) gene are the most frequent cause of Cr deficiency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e78b5d263c9b195e320cd67464cd3a95
https://doi.org/10.1101/2022.06.02.494536
https://doi.org/10.1101/2022.06.02.494536
Autor:
Nicholas Delcimmuto, Matthew R. Skelton, Kenea C. Udobi, Zuhair I. Abdulla, Amanda N. Kokenge, Marla K. Perna
Publikováno v:
J Inherit Metab Dis
Creatine (Cr) is a guanidino compound that provides readily-available phosphate pools for the regeneration of spent ATP. The lack of brain Cr causes moderate to severe intellectual disability, language impairment, and epilepsy. The most prevalent cau
Autor:
Matthew R. Skelton, Pascale de Lonlay, Alain Pruvost, Aloïse Mabondzo, Frédéric Taran, Sophie Dezard, Gabriela Ullio-Gamboa, Narciso Costa, Jean-Pierre Benoit, Keila N. Miles, Marla K. Perna, Kenea C. Udobi
Publikováno v:
Nanomedicine (London, England)
Nanomedicine (London, England), 2019, 14 (12), pp.1579-1593. ⟨10.2217/nnm-2019-0059⟩
Nanomedicine (Lond)
Nanomedicine (London, England), 2019, 14 (12), pp.1579-1593. ⟨10.2217/nnm-2019-0059⟩
Nanomedicine (Lond)
Creatine transporter (CrT) deficiency is an X-linked intellectual disability caused by mutations of CrT. Aim: This work focus on the preclinical development of a new therapeutic approach based on a microemulsion (ME) as drug delivery system for dodec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbb99fa342182a6571bfdb70d2ae06d
https://hal.univ-angers.fr/hal-02616077
https://hal.univ-angers.fr/hal-02616077
Autor:
Kenea C. Udobi, Matthew R. Skelton, Keila N. Miles, Amanda N. Kokenge, Marla K. Perna, Gail J. Pyne-Geithman, Joseph F. Clark, Zaza Khuchua
Publikováno v:
Amino Acids. 48:2057-2065
Creatine (Cr) is a guanidino compound required for rapid replenishment of ATP in cells with a high-energy demand. In humans, mutations in the Cr transporter (CRT;SLC6A8) prevent Cr entry into tissue and result in a significant intellectual impairment
Autor:
Russell W. Brown, Marla K. Perna
Publikováno v:
Behavioural Brain Research. 242:102-109
Our laboratory has reported neonatal quinpirole (D 2 /D 3 agonist) treatment to rats increases dopamine D 2 receptor sensitivity that persists throughout the animal's lifetime. This model appears to have clinical relevance to schizophrenia, and smoki
Autor:
Zackary A. Cope, A. Brianna Sheppard, Richard M. Kostrzewa, Amanda M. Maple, Russell W. Brown, Marla K. Perna
Publikováno v:
Developmental Neuroscience. 34:140-151
This review focuses on nicotine comorbidity in schizophrenia, and the insight into this problem provided by rodent models of schizophrenia. A particular focus is on age differences in the response to nicotine, and how this relates to the development
Autor:
Ryan T. Lacy, Marla K. Perna, Russell W. Brown, Steven B. Harrod, Benjamin A. Hughes, Jun Zhu
Publikováno v:
Synapse. 65:1382-1392
Maternal smoking during pregnancy is associated with enduring psychopathology, such as increased likelihood of substance use, in offspring. Various animal models demonstrate that continuous nicotine exposure produces teratogenic effects in offspring,
Autor:
Marla K. Perna, Russell W. Brown, Daniel M. Noel, Jamie D. Whittemore, Meredith L. Smith, Julia Lehmann
Publikováno v:
Behavioural Pharmacology. 22:374-378
Neonatal quinpirole treatment has been shown to produce an increase in dopamine D2-like receptor sensitivity that persists throughout the subject's lifetime. The objective was to analyze the effects of neonatal quinpirole treatment on effects of amph
Autor:
Amanda M. Maple, Zackary A. Cope, Jennifer A. Correll, Ian D. Longacre, Marla K. Perna, Russell W. Brown
Publikováno v:
Psychopharmacology. 199:67-75
Increases in dopamine D2-like receptor function are common in several psychological disorders that demonstrate a four to five fold increase in nicotine abuse compared to the general population.The objective of this study was to analyze the interactio
Publikováno v:
Brain Research. 1200:66-77
Neonatal quinpirole (dopamine D(2)/D(3) agonist) treatment to rats has been shown to increase dopamine D(2) receptor sensitivity throughout the animal's lifetime. Male and female Sprague-Dawley rats were neonatalally treated with quinpirole (1 mg/kg)