Výsledky vyhledávání - "Marla J. Smith"

Serial Changes in Norepinephrine Kinetics Associated With Feeding Dogs a High-Fat Diet

Autor: Marla J. Smith, John Q. Yang, Mark A. Supiano, Albert P. Rocchini

Publikováno v: J Clin Hypertens (Greenwich)

J Clin Hypertens (Greenwich). 2010;12:117–124. (©)2009 Wiley Periodicals, Inc. The role of increased sympathetic nervous system (SNS) activity in the pathogenesis of obesity hypertension and insulin resistance is controversial. Eight dogs were ins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033480587b739fe24bb650376345bc9e
https://doi.org/10.1111/j.1751-7176.2009.00230.x

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Impaired β-Cell Function in Human Aging: Response to Nicotinic Acid-Induced Insulin Resistance

Autor: Marla J. Smith, Andrzej T. Galecki, Annette M. Chang, Jeffrey B. Halter, Cathie J. Bloem

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 91:3303-3309

Context: Glucose tolerance declines with age and may involve impaired β-cell sensitivity to glucose and β-cell compensation for insulin resistance. Objective: We investigated β-cell sensitivity to glucose and β-cell compensation for nicotinic aci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d75c8b34a6ada44a667cd0e75fc58d
https://doi.org/10.1210/jc.2006-0913

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Ordinary Differential Equation PK/PD Models Using the SAS Macro NLINMIX

Autor: Andrzej T. Galecki, Jeffrey B. Halter, Marla J. Smith, Russell D. Wolfinger, Oscar A. Linares

Publikováno v: Journal of Biopharmaceutical Statistics. 14:483-503

We describe some theory and recent enhancements for the SAS macro NLINMIX (Wolfinger, R. D. (1993). Laplace's approximation for nonlinear mixed effects models. Biometrika 80:791-795) that enable model calculation to take place within the interaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9d9147a3bb7e2ad0ae7b41681b73ae
https://doi.org/10.1081/bip-120037194

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Changes in systemic sympathetic nervous system activity after mitral valve surgery and their relationship to changes in left ventricular size and systolic performance in patients with mitral regurgitation

Autor: Rajendra H. Mehta, Hakan Oral, P. Michael Grossman, Marla J. Smith, Mark R. Starling, Kerri Briesmiester, Daniel G. Montgomery, Mark A. Supiano

Publikováno v: American Heart Journal. 147:729-735

We have shown that the systemic sympathetic nervous system (SNS) is activated in patients with chronic mitral regurgitation (MR). However, the fate of systemic SNS activity after surgical correction of MR is currently unknown.We examined 14 patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38314cd0cdb9c93429e481d88dce952b
https://doi.org/10.1016/j.ahj.2003.10.020

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The GLP-1 Derivative NN2211 Restores β-Cell Sensitivity to Glucose in Type 2 Diabetic Patients After a Single Dose

Autor: Jeppe Sturis, Marla J. Smith, Annette M. Chang, Cathie J. Bloem, Jeffrey B. Halter, Bob An, Grethe Jakobsen, Andrzej T. Galecki

Publikováno v: Diabetes. 52:1786-1791

Glucagon-like peptide 1 (GLP-1) stimulates insulin secretion in a glucose-dependent manner, but its short half-life limits its therapeutic potential. We tested NN2211, a long-acting GLP-1 derivative, in 10 subjects with type 2 diabetes (means +/- SD:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3077800db27028e975be94dbb96bee8
https://doi.org/10.2337/diabetes.52.7.1786

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Compared with control subjects, the systemic sympathetic nervous system is activated in patients with mitral regurgitation

Autor: Daniel Montgomery, P. Michael Grossman, Marla J. Smith, Hakan Oral, Mark A. Supiano, Mark R. Starling, Rajendra H. Mehta

Publikováno v: American Heart Journal. 145:1078-1085

Background Whether the systemic sympathetic nervous system is activated as a compensatory mechanism in response to mitral regurgitation (MR) in humans is unknown. We tested the hypotheses that the systemic sympathetic nervous system would be activate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66119f199b7e300dbc458795a5fdfe71
https://doi.org/10.1016/s0002-8703(03)00111-x

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Hypoglycemia counterregulation in elderly humans: relationship to glucose levels

Autor: Jeffrey B. Halter, William H. Herman, Marla J. Smith, J. A. Jacquez, F. J. Ortiz-Alonso, Andrzej T. Galecki

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 267:E497-E506

This study was designed to define the effect of human aging on hypoglycemia counterregulatory mechanisms. A hyperinsulinemic (2 mU.kg-1.min-1) glucose clamp procedure was used to control glucose and insulin levels during stepwise lowering of plasma g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf43c0715b20c973700c3c7af9d85f1
https://doi.org/10.1152/ajpendo.1994.267.4.e497

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Effect of desipramine on norepinephrine metabolism in humans: interaction with aging

Autor: Marla J. Smith, Mark A. Supiano, J. S. Stromberg, Oscar A. Linares, A. H. Foster, Jeffrey B. Halter

Publikováno v: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 261:R1484-R1490

To determine whether differences in neuronal reuptake contribute to age-related changes of sympathetic nervous system activity, we compared norepinephrine (NE) release and metabolism during [3H]NE infusion and decay in six young (age 19-26 yr) and se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a0369892d7bcece5e7b2f682d293eb
https://doi.org/10.1152/ajpregu.1991.261.6.r1484

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Effect of an oral α2-adrenergic blocker (MK-912) on pancreatic islet function in non-insulin-dependent diabetes mellitus

Autor: Marla J. Smith, Vanessa C. Williams, William H. Herman, F.Javier Ortiz-Alonso, Jeffrey B. Halter, Barry J. Gertz

Publikováno v: Metabolism. 40:1160-1167

We used MK-912, a potent new selective α 2 -adrenergic receptor antagonist that is active orally, to study the effect of short-term, selective α 2 -blockade on fasting plasma glucose (FPG) and pancreatic islet function in non-insulin-dependent diab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb797da4bb00792e90139faaca72130
https://doi.org/10.1016/0026-0495(91)90210-n

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Limitation of the homeostasis model assessment to predict insulin resistance and beta-cell dysfunction in older people

Autor: Jeffrey B. Halter, Marla J. Smith, Andrzej T. Galecki, Annette M. Chang, Mark A. Supiano, Cathie J. Bloem

Publikováno v: The Journal of clinical endocrinology and metabolism. 91(2)

Context: Studies in older people have shown inconsistent agreement between homeostasis model assessment of insulin resistance (HOMA-IR) and dynamic measures of insulin action and have not evaluated HOMA β-cell. Objective: We compared measures of ins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a40e9211849051aefb586265d31cca6
https://pubmed.ncbi.nlm.nih.gov/16317057

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