Characterization of the EM66 Biomarker in the Pituitary and Plasma of Healthy Subjects With Different Gonadotroph Status and Patients With Gonadotroph Tumor

Autor: Johann Guillemot, Marlène Guérin, Anne-Françoise Cailleux, Antoine-Guy Lopez, Jean-Marc Kuhn, Youssef Anouar, Laurent Yon

Publikováno v: Frontiers in Endocrinology, Vol 10 (2019)

Granins and their derived-peptides are useful markers of secretion from normal and tumoral neuroendocrine cells. The need to identify new diagnostic markers for neuroendocrine tumors, including pituitary tumors prompted us to determine plasma levels

Externí odkaz: https://doaj.org/article/85ac8a967e9c42da837cece3f48a9e32

Characterization and plasma measurement of the WE-14 peptide in patients with pheochromocytoma

Autor: Laurent Yon, Marc Klein, Maité Montero-Hadjadje, Youssef Anouar, Marlène Guérin, Jérôme Leprince, Hervé Lefebvre, Erwan Thouënnon, Mihaela Muresan, Johann Guillemot

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e88698 (2014)
PLoS ONE
PLoS ONE, Public Library of Science, 2014, 9 (2), pp.88698-88698. ⟨10.1371/journal.pone.0088698⟩

International audience; Granins and their derived peptides are valuable circulating biological markers of neuroendocrine tumors. The aim of the present study was to investigate the tumoral chromogranin A (CgA)-derived peptide WE-14 and the potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2777d21fae64e898a37cd81ca82e276c
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24523932/?tool=EBI

Differential expression and processing of secretogranin II in relation to the status of pheochromocytoma: implications for the production of the tumoral marker EM66

Autor: Erwann Thouennon, Aurelia Ravni, Marc Klein, Maité Montero-Hadjadje, Johann Guillemot, Marlène Guérin, Mihaela Muresan, Nabil G. Seidah, Laurent Yon, Youssef Anouar, Hervé Lefebvre, Virginie Vallet-Erdtmann

Publikováno v: Journal of Molecular Endocrinology
Journal of Molecular Endocrinology, BioScientifica, 2012, 48 (2), pp.115-127. ⟨10.1530/JME-11-0077⟩
Journal of Molecular Endocrinology, 2012, 48 (2), pp.115-127. ⟨10.1530/JME-11-0077⟩

We have previously demonstrated that measurement of tissue concentrations of the secretogranin II (SgII or SCG2 as listed in the HUGO database)-derived peptide EM66 may help to discriminate between benign and malignant pheochromocytomas and that EM66

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4de582f39df5e196e152e02340e9c32
https://hal-normandie-univ.archives-ouvertes.fr/hal-01706410

Granins and their derived peptides in normal and tumoral chromaffin tissue: Implications for the diagnosis and prognosis of pheochromocytoma

Autor: Laurent Yon, Youssef Anouar, Alice Pierre, Christophe Dubessy, Maité Montero-Hadjadje, Erwan Thouënnon, Isabelle Lihrmann, Johann Guillemot, Marlène Guérin, Rabia Magoul, Fatima-Zohra El-Yamani

Publikováno v: Regulatory Peptides
Regulatory Peptides, Elsevier, 2010, 165 (1), pp.21-29. ⟨10.1016/j.regpep.2010.06.003⟩

International audience; Pheochromocytomas are rare catecholamine-secreting tumors that arise from chromaffin tissue within the adrenal medulla and extra-adrenal sites. Typical clinical manifestations are sustained or paroxysmal hypertension, severe h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb79c45b3fc939a12cce330e69210a64
https://pubmed.ncbi.nlm.nih.gov/20600356