Výsledky vyhledávání - "Markus Zollinger"

A Study of the Effect of Cyclosporine on Fevipiprant Pharmacokinetics and its Absolute Bioavailability Using an Intravenous Microdose Approach

Autor: Kenichi Umehara, Veit J. Erpenbeck, Markus Zollinger, H. Markus Weiss, Meredith Cain, Walid Elbast, Janardhana Vemula

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 48(10)

This drug-drug interaction (DDI) study determined the effect of cyclosporine, an inhibitor of OATP1B3 and P-gp, on the pharmacokinetics (PK) of fevipiprant, an oral, highly selective, competitive antagonist of the prostaglandin D2 receptor 2 and a su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33905215fdcf557fb1381b6c5c26c530
https://pubmed.ncbi.nlm.nih.gov/32739890

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Esterase phenotyping in human liver in vitro: specificity of carboxylesterase inhibitors

Autor: Elizabeth Kigondu, Felix Huth, Markus Zollinger, Gian Camenisch, Claire Juif, Marc Witschi, Hilmar Schiller, Kelly Chibale, Kenichi Umehara

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 46(10)

1. Esterases may play a major role in the clearance of drugs with functional groups amenable to hydrolysis, particularly in the case of ester prodrugs. To understand the processes involved in the elimination of such drugs, it is necessary to determin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf8cd51730b0588638d712b4632136e
https://pubmed.ncbi.nlm.nih.gov/26887925

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Metabolism of patupilone in patients with advanced solid tumor malignancies

Autor: Piet Swart, Frédéric Lozac'h, Felix Waldmeier, Kevin R. Kelly, Yanfeng Wang, Patrick Urban, Suraj Anand, Eugene Tan, Chris H. Takimoto, Alain C. Mita, Markus Zollinger, Monica M. Mita

Publikováno v: Investigational New Drugs. 31:605-615

A phase 1, open-label, non-randomized, single center study was conducted to determine the pharmacokinetics, distribution, metabolism, elimination, and mass balance of patupilone in patients with advanced solid tumors. Five patients with advanced soli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b63082020fd56d339e84eb78f6fc6a1
https://doi.org/10.1007/s10637-012-9838-2

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Absorption and Disposition of the Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) in Healthy Volunteers: A Case of Xenobiotic Biotransformation Following Endogenous Metabolic Pathways

Autor: Yi Jin, Markus Zollinger, Stefan Hartmann, Frédéric Zecri, Claudia Sayer, Hans-Peter Gschwind

Publikováno v: Drug Metabolism and Disposition. 39:199-207

Fingolimod [(FTY720), Gilenya; 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol], a new drug for the treatment of relapsing multiple sclerosis, acts through its phosphate metabolite, which modulates sphingosine 1-phosphate receptors. This represent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb8fb74760f80fd11a0c92e52afc63a
https://doi.org/10.1124/dmd.110.035907

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A microplate solid scintillation counter as a radioactivity detector for high performance liquid chromatography in drug metabolism: Validation and applications

Autor: Markus Zollinger, Gerard Bruin, Felix Waldmeier, Gerhard Gross, K. Olaf Boernsen, Ulrike Pfaar

Publikováno v: Journal of Chromatography A. 1133:184-194

Sensitive radioactivity detection following high performance liquid chromatography (HPLC) separation remains a challenge in many drug metabolism studies with radiolabeled compounds. In this work, solid scintillation counting (SSC) after fraction coll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1197a7dc753344dfb3f7ac67dac8871
https://doi.org/10.1016/j.chroma.2006.08.020

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PIMECROLIMUS: ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION IN HEALTHY VOLUNTEERS AFTER A SINGLE ORAL DOSE AND SUPPLEMENTARY INVESTIGATIONS IN VITRO

Autor: Markus Zollinger, Gerhard Zenke, Alfred Zimmerlin, Thomas Moenius, Stefan Hartmann, Maximilian Grassberger, Felix Waldmeier, Ulrike Glaenzel, Alain Schweitzer, Jean-Pierre Baldeck, Stephane Berthier

Publikováno v: Drug Metabolism and Disposition. 34:765-774

The absorption and disposition of pimecrolimus, a calcineurin inhibitor developed for the treatment of inflammatory skin diseases, was investigated in four healthy volunteers after a single oral dose of 15 mg of [(3)H]pimecrolimus. Supplementary info

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a9a763baa7bd3fe3ce0cd94e5df61f
https://doi.org/10.1124/dmd.105.007732

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Novel Immunomodulator FTY720 Is Phosphorylated in Rats and Humans To Form a Single Stereoisomer. Identification, Chemical Proof, and Biological Characterization of the Biologically Active Species and Its Enantiomer

Autor: Eric Francotte, Danilo Guerini, Markus Streiff, Markus Zollinger, Karl Welzenbach, Rainer Albert, Klaus Hinterding, Trixie Wagner, Helmut Knecht, Nigel Graham Cooke, Frédéric Zecri, Corinne Simeon, Constanze Müller-Hartwieg, Volker Brinkmann

Publikováno v: Journal of Medicinal Chemistry. 48:5373-5377

In vivo phosphorylation of FTY720 (1) in rats and humans resulted exclusively in the biologically active (S)-configured enantiomer, which was proven by an ex vivo o-phthaldialdehyde derivatization protocol especially elaborated for phosphates of 1. S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b15be152523830d14deb51d14f71330
https://doi.org/10.1021/jm050242f

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METABOLISM AND DISPOSITION OF IMATINIB MESYLATE IN HEALTHY VOLUNTEERS

Autor: Monique Ben-Am, Felix Waldmeier, Hans-Peter Gschwind, Rolf Pokorny, Michael Hayes, Ulrike Pfaar, Bin Peng, Peter Zbinden, Markus Zollinger, Gerhard Gross, Michael Seiberling, Claudia Sayer

Publikováno v: Drug Metabolism and Disposition. 33:1503-1512

Imatinib mesylate (GLEEVEC, GLIVEC, formerly STI571) has demonstrated unprecedented efficacy as first-line therapy for treatment for all phases of chronic myelogenous leukemia and metastatic and unresectable malignant gastrointestinal stromal tumors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e027c42a2c6cdbce21e1c91a19e7028b
https://doi.org/10.1124/dmd.105.004283

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Release of N-Acetylaspartylglutamate from Slices of Rat Cerebellum, Striatum, and Spinal Cord, and the Effect of Climbing Fiber Deprivation

Autor: Kim Q. Do, Michel Cuenod, Peter Streit, Ursula Gutteck-Amsler, Markus Zollinger, J. Brauchli‐Theotokis

Publikováno v: Journal of Neurochemistry. 63:1133-1142

The release of endogenous N-acetylaspartylglutamate (NAAG) from slices of rat cerebellum, striatum, and spinal cord upon depolarization with 50 mM K+ was investigated. NAAG in superfusates was prepurified using an ion exchanger, esterified, and then

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f47c295ce2173ede0e9619dc60b2352
https://doi.org/10.1046/j.1471-4159.1994.63031133.x

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