Improved Prediction of in Vivo Supersaturation and Precipitation of Poorly Soluble Weakly Basic Drugs Using a Biorelevant Bicarbonate Buffer in a Gastrointestinal Transfer Model

Autor: Christian Jede, Lassina Badolo, Christian Wagner, Christian Weber, Markus Weigandt, Mirko Koziolek, Holger Kubas, Werner Weitschies, Marc Lecomte

Publikováno v: Molecular Pharmaceutics. 16:3938-3947

The characterization of intestinal dissolution of poorly soluble drugs represents a key task during the development of both new drug candidates and drug products. The bicarbonate buffer is considered as the most biorelevant buffer for simulating inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955d5f1234940b05dbea5643c803e890
https://doi.org/10.1021/acs.molpharmaceut.9b00534

The effect of polymer size and charge of molecules on permeation through synovial membrane and accumulation in hyaline articular cartilage

Autor: Claus-Michael Lehr, B. Sterner, Markus Weigandt, Meike Harms, Maike Windbergs, Steffen Wöll

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics. 101:126-136

The treatment of joint related diseases often involves direct intra-articular injections. For rational development of novel delivery systems with extended residence time in the joint, detailed understanding of transport and retention phenomena within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85eb7269d8bebdb65faf08e3efd4de48
https://doi.org/10.1016/j.ejpb.2016.02.004

Drug Loading of Polymeric Micelles

Autor: Senta Uezguen, Mariola Monika Golas, Bjoern Sander, Achim Goepferich, Gwenaelle van Colen, Markus Weigandt, Tobias Miller

Publikováno v: Miller, T, van Colen, G, Sander, B, Golas, M M, Uezguen, S, Weigandt, M & Goepferich, A 2013, ' Drug Loading of Polymeric Micelles ', Pharmaceutical Research, vol. 30, no. 2, pp. 584-595 . https://doi.org/10.1007/s11095-012-0903-5

PURPOSE: To gain mechanistic insights into drug loading and lyophilization of polymeric micelles.METHODS: PEGylated poly-4-(vinylpyridine) micelles were loaded with dexamethasone. Three different methods were applied and compared: O/W emulsion, direc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf47ee56893de1a5097a6afcb143e8e
https://doi.org/10.1007/s11095-012-0903-5

Crystal suspensions of poorly soluble peptides for intra-articular application: a novel approach for biorelevant assessment of their in vitro release

Autor: M. Harms, Claus-Michael Lehr, Maike Windbergs, Markus Weigandt, B. Sterner

Publikováno v: International journal of pharmaceutics. 461(1-2)

Crystal suspensions of 3 poorly soluble peptides (MSC1, 2 and 3), intended for intra-articular administration were prepared and in vitro release was tested by a modified USP IV apparatus, combined with a dialysis system. Half-lives of release profile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f91b43d45e6ca6fee985a72120acd16c
https://pubmed.ncbi.nlm.nih.gov/24280019

How do in-vitro release profiles of nanosuspensions from Alzet® pumps correspond to the in-vivo situation? A case study on radiolabeled fenofibrate

Autor: Markus Weigandt, Karsten Mäder, Uwe Haberkorn, Simon Geissler, Sandra Breyer, Walter Mier, Alexandra Hill

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 168(1)

In research and development sufficiently high and constant plasma levels of drug candidates are often requested, but simple solutions of hydrophobic drugs delivered from the commonly used micro-osmotic pumps cannot meet these demands. Nanosuspensions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568b7adfaa8a059e04eb84d868b16250
https://pubmed.ncbi.nlm.nih.gov/23499716